Effects of fetal gender and low first trimester aneuploidy screening markers on preterm birth

Kanmaz, Ahkam Göksel; İnan, Abdurrahman Hamdi; Beyan, Emrah; Karataşlı, Volkan; Çakır, İlker; Budak, Adnan; Emirdar, Volkan

doi:10.1016/j.jogoh.2019.01.011

Cited by 7 publications

(6 citation statements)

References 22 publications

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“…The relationship between fetal gender and adverse pregnancy outcome is controversial [50,51]. The male sex, especially in low-risk pregnancies, seems to have an effect on adverse pregnancy outcomes [52] such as preterm births [53,54] and stillbirths [55]. During the ZIKV outbreak on Yap Island, a higher prevalence of IgM antibody against ZIKV was found in men as compared to women [15].…”

Section: Discussionmentioning

confidence: 99%

Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis

et al. 2020

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Background: Although it is known that Zika virus (ZIKV) infection during pregnancy may lead to microcephaly in the fetus, the prognostic factors associated with this tragic disorder remain unclear. We conducted a systematic review and meta-analysis to assess the prognostic factors associated with the incidence of microcephaly in congenital ZIKV infection. Methods: We conducted a comprehensive search in Ovid MEDLINE, Ovid MEDLINE (R) Epub ahead of print, Embase, Embase Classic, Web of Science, CINAHL, Cochrane CENTRAL, LILACS, and various thesis databases to identify human studies reporting microcephaly associated with congenital ZIKV infection. We requested primary data from the authors of the included studies to calculate summary estimates and conduct the meta-analysis of the most prevalent factors. Results: We screened 4106 titles and abstracts, and identified 12 studies for inclusion in the systematic review. The assessment of ZIKV infection and the definition of microcephaly varied among studies. A total of 6154 newborns/ fetuses were enrolled; of those, 1120 (18.20%) had a diagnostic of ZIKV infection, of which 509 (45.45%) were diagnosed with microcephaly. Nine studies addressed the link between congenital ZIKV infection and neurological findings in newborns/fetuses. Half of the studies provided primary data. Three out of 11 factors of interest seem to be prognostic factors of microcephaly: infant's sexmales compared to females: Relative Risk (RR) 1.30, 95% Confidence Interval (95% CI) 1.14 to 1.49; the stage of pregnancy when infection occurredinfection in the first trimester of pregnancy compared to infection at other stages of pregnancy: RR 1.41, 95% CI 1.09 to 1.82; and asymptomatic infection compared to symptomatic infection during pregnancy: RR 0.68; 95% CI 0.60 to 0.77. Conclusion: Our findings support the female-biased resistance hypothesis and reinforce the risk associated with the stage of pregnancy when ZIKV infection occurs. Continued surveillance of ZIKV infection during pregnancy is needed to identify additional factors that could contribute to developing microcephaly in affected fetuses.

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Section: Discussionmentioning

confidence: 99%

Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis

et al. 2020

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“…The lower probability of prematurity observed for females in the present study has also been found in several studies. Among the most recent, a Turkish study carried out in 29,528 pregnant women, 7,382 of whom had preterm deliveries, showed a significantly lower prematurity in 24.3% of female versus 25.7% of male newborns (p-value = 0.004) (Kanmaz et al, 2019). However, no significant association between sex and preterm births was found in a sample of 2,505 pregnant women from UK, 230…”

Section: Discussionmentioning

confidence: 96%

Prenatal Se concentrations and anthropometry at birth in the INMA study (Spain)

Lozano

Murcia

Soler-Blasco

et al. 2020

Environmental Research

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We assessed whether prenatal selenium (Se) exposure is associated with anthropometry at birth, placental weight and gestational age. Study subjects were 1249 mother-child pairs from the Valencia and Gipuzkoa cohorts of the Spanish Childhood and Environment Project (INMA, 2003-2008). Se was determined in serum samples taken at the first trimester of pregnancy. Socio-demographic and dietary characteristics were also collected by questionnaires. Mean (SD) serum Se concentration was 79.57 (9.64) μg/L. Se showed weak associations with both head circumference and gestational age. The association between serum Se concentration and birth weight and length was negative, and direct for placental weight and probability of preterm birth, although the coefficients did not reach statistical significance. Individuals with total mercury (THg) levels >15 μg/L reversed the serum Se concentration effect on head circumference. Significant interactions were found between sex and both gestational age and prematurity. Spontaneous birth gestational ages were estimated to be lower for males and their probability of prematurity was higher. In conclusion, prenatal Se exposure may be associated with lower head circumference and lower gestational ages at spontaneous birth. Interactions with THg exposure and gender should be considered when assessing these relationships.

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“…The relationship between fetal sex and adverse pregnancy outcome is controversial [50,51]. The male sex, especially in low-risk pregnancies, seems to have an effect on adverse pregnancy outcomes [52], such as preterm birth [53,54] and stillbirths [55]. During the ZIKV outbreak on Yap Island, a higher prevalence of IgM antibody was found against ZIKV in men, compared to women [15].…”

Section: Discussionmentioning

confidence: 99%

Another piece on the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis.

Gallo

Martínez-Cajas

Peixoto

et al. 2020

Preprint

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Background: Although it is known that Zika virus (ZIKV) infection during pregnancy may lead to microcephaly in the foetus, the risk factors associated to this tragic disorder remain unclear. We conducted a systematic review and meta-analysis toto assess risk factors associated with the incidence of microcephaly in congenital ZIKV infection. Methods: We conducted a comprehensive search in Ovid MEDLINE, Ovid MEDLINE (R) Epub ahead of print, Embase, Embase Classic, Web of Science, CINAHL, Cochrane CENTRAL, LILACS and various thesis databases to identify human studies reporting microcephaly associated with congenital ZIKV infection. We requested primary data from authors of the studies included in this review to calculate summary estimates and conduct meta-analysis of the most prevalent factors. Results: We screened 4,106 titles and abstracts, and identified 12 studies for inclusion in the systematic review. The assessment of ZIKV infection and the definition of microcephaly varied among studies. A total of 6,154 children/foetuses were enrolled; of those, 1,120 (18.20%) had a diagnostic of ZIKV infection, of which 509 (45.45%) were diagnosed with microcephaly. Nine studies addressed the link between congenital ZIKV infection and neurological findings in foetuses/ children. Half of the studies provided primary data. Two out of eleven factors of interest were associated with microcephaly: infant’s sex – males presented a higher risk of microcephaly compared to females (RR 1.30, 95% CI 1.14, 1.49); and the stage of pregnancy when infection occurred - infection in the first trimester of pregnancy had a higher risk of microcephaly (RR 1.41, 95% CI 1.09 to 1.82), compared to infection at other stages of pregnancy. Conclusion: Our findings support the female-biased resistance hypothesis and reinforce the risk associated with the stage of pregnancy when Zika virus infection occurs. Continued surveillance of ZIKV during pregnancy is needed to identify additional factors that could contribute to developing microcephaly in affected foetuses.

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Effects of fetal gender and low first trimester aneuploidy screening markers on preterm birth

Cited by 7 publications

References 22 publications

Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis

Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis

Prenatal Se concentrations and anthropometry at birth in the INMA study (Spain)

Another piece on the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis.

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