Effects of fetal exposure to carbon nanoparticles on reproductive function in male offspring

Yoshida, Seiichi; Hiyoshi, Kyoko; Oshio, Shigeru; Takano, Hirohisa; Takeda, Ken; Ichinose, Takamichi

doi:10.1016/j.fertnstert.2009.03.094

Cited by 115 publications

(81 citation statements)

References 12 publications

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“…Time-mated mice were intratracheally instilled with carbon black dispersed in saline solution with 0.05% Tween 80 (0.2 mg/animal total dose) on GD 7 and 14. Similar to our studies, no effects on gestation were observed (Yoshida et al, 2010). In conclusion, pulmonary exposure to nanoparticles repeatedly did not induce maternal toxicity or fetotoxicity and developmental toxicity.…”

Section: Gestation and Lactationsupporting

confidence: 91%

“…Adverse effects of prenatal exposure to engineered nanoparticles in vitro and in vivo have been summarized by (Ema et al, 2010;Hougaard et al, 2011). The effects observed in animals include altered immune response, development of the nervous system and reproductive function (Fedulov et al, 2008;Lamoureux et al, 2010;Shimizu et al, 2009;Takahashi et al, 2010;Takeda et al, 2009;Yoshida et al, 2009;Yoshida et al, 2010).…”

Section: Ambient Air Pollutionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal Exposure to Particulate Air Pollution and Engineered Nanoparticles: Reproductive and Developmental Effects

Jackson¹,

Vogel²,

Wallin³

et al. 2011

Air Pollution - New Developments

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Section: Gestation and Lactationsupporting

confidence: 91%

Section: Ambient Air Pollutionmentioning

confidence: 99%

Maternal Exposure to Particulate Air Pollution and Engineered Nanoparticles: Reproductive and Developmental Effects

Jackson¹,

Vogel²,

Wallin³

et al. 2011

Air Pollution - New Developments

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“…The prenatal exposure of mice to carbon black (14 nm) (200 μg) was shown to affect reproductive function, damage the seminiferous epithelium and reduce the DSP numbers in male offspring (Yoshida et al, 2010). It is possible that the damage of the seminiferous epithelium by TiO 2 -NPs is caused by a characteristic of their nano-size, which can induce reactive oxygen species or oxidative stress in mice (Trouiller et al, 2009) as it has also been reported that nanotubes that accumulated in the mice testes, generated oxidative stress and decreased the thickness of the seminiferous epithelium in the testes at 15 days after injection (Bai et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Prenatal exposure to rutile-type alumina-coated titanium dioxide nanoparticles impairs mouse spermatogenesis

Kubo-Irie

Shinkai

Matsuzawa

et al. 2016

Fundam. Toxicol. Sci.

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-The in vivo nanotoxicity of nanoparticles is drawing increased attention as concerns grow over the biosafety of nanotechnology. TiO 2 nanoparticles are coated to decrease the potential of harmful effects due to their photoactivity. Rutile-type alumina-coated titanium dioxide nanoparticles (Al 2 O 3 -TiO 2 -NPs) are frequently used in cosmetics to improve their dispersion stability. We herein discuss the effects of Al 2 O 3 -TiO 2 -NPs exposure during pregnancy on mouse spermatogenesis. Pregnant mice were injected five times, once each with 0.1 mL of sequentially diluted concentrations of a Al 2 O 3 -TiO 2 -NPs suspension (1, 10, 100 or 1,000 μg/mL) and received doses of 0.5, 5, 50 and 500 μg, respectively. Prior to injection, the size distribution of the Al 2 O 3 -TiO 2 -NPs was analyzed by dynamic light scattering (DLS) measurement. The average diameter was increased in dose-dependent manner from an average of 153.8 nm to 654.6 nm. The offspring testes were examined at 12 weeks postpartum. The agglomerates in the testicular sections were small (< 200 nm). They were confirmed by the characteristic peaks of the Ti and Al elements on field emission-scanning electron microscope/energy dispersive X-ray spectroscopy (FE-SEM/EDS). Low cellular adhesion and degenerated Sertoli cells were observed in the seminiferous epithelium of all of the Al 2 O 3 -TiO 2 -NP recipient groups by a histological analysis. The detrimental function of the Sertoli cells resulted in the formation of abnormal spermatozoa. The results suggested that Al 2 O 3 -TiO 2 -NPs that transferred from the mother's body affected spermatogenesis in the offspring.

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“…Some particles can affect the male reproductive function [16,17]. We have also shown that fetal exposure to diesel exhaust and carbon nanoparticles impairs the male reproductive function of male offspring [18,19]. Another report indicates that approximately 51% of all human offspring had previously been males but that a decline in the sex ratio at birth or secondary sex ratio (SSR) has occurred since the middle of the 20th century [20].…”

Section: Introductionmentioning

confidence: 89%

Effects of Fetal Exposure to Asian Sand Dust on Fetal Development and Reproductive Function in Male Offspring

Yoshida¹,

Ichinose²,

Arashidani³

et al. 2016

Preprint

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Abstract:In recent experimental studies, we reported the aggravating effects of Asian sand dust (ASD) on male reproductive function in mice. However, the effects of fetal ASD exposure on male reproductive function have not been investigated. The present study investigated the effects of fetal ASD exposure on reproductive function in male offspring. Using pregnant CD-1 mice, ASD was administered intratracheally on days 7 and 14 of gestation, and the reproductive function of male offspring was determined at 5, 10, and 15 weeks after birth. The secondary sex ratio was significantly lower in the fetal ASD-exposed mice than in the controls. Histologic examination showed partial vacuolation of seminiferous tubules in immature mice. Moreover, daily sperm production (DSP) was significantly less in the fetal ASD-exposed mice than in the controls. DSP in the fetal ASD-exposed mice was approximately 10% less than the controls at both 5 and 10 weeks. However, both the histologic changes and the DSP decrease were reversed as the mice matured. These findings suggest that ASD exposure affects both the fetal development and the reproductive function of male offspring. In the future, it will be necessary to clarify the onset mechanisms of ASD-induced male fetus death and male reproductive disorders.

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Effects of fetal exposure to carbon nanoparticles on reproductive function in male offspring

Cited by 115 publications

References 12 publications

Maternal Exposure to Particulate Air Pollution and Engineered Nanoparticles: Reproductive and Developmental Effects

Maternal Exposure to Particulate Air Pollution and Engineered Nanoparticles: Reproductive and Developmental Effects

Prenatal exposure to rutile-type alumina-coated titanium dioxide nanoparticles impairs mouse spermatogenesis

Effects of Fetal Exposure to Asian Sand Dust on Fetal Development and Reproductive Function in Male Offspring

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