Effects of fermented red bean extract on nephropathy in streptozocin-induced diabetic rats

Chan, Kung‐Chi; Kok, Kar-Eng; Huang, Keh‐Feng; Weng, Yao-Lin; Chung, Yun‐Chin

doi:10.29219/fnr.v64.4272

Cited by 8 publications

(2 citation statements)

References 46 publications

(50 reference statements)

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“…In the previous studies to evaluate the antihypertensive effect of adzuki bean extracts, adzuki bean extracts were fed with feed rather than oral gavage [ 24 , 25 ]. Consequently, the experimental doses (250 and 500 mg/kg) of BE and AE were determined based on previous studies related to other physiological activities rather than antihypertensive activity [ 27 , 28 ]. All treatments were dissolved in 0.5% ( w / v ) carboxymethyl cellulose in saline (Sigma-Aldrich, St. Louis, MO, USA), and orally administered to the rats every day for eight weeks.…”

Section: Methodsmentioning

confidence: 99%

Black Soybean and Adzuki Bean Extracts Lower Blood Pressure by Modulating the Renin-Angiotensin System in Spontaneously Hypertensive Rats

Jeong

Yang

Baek

et al. 2021

Foods

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Hypertension, causing cardiovascular disease, stroke, and heart failure, has been a rising health issue worldwide. Black soybeans and adzuki beans have been widely consumed throughout history due to various bioactive components. We evaluated the antihypertensive effects of black soybean and adzuki bean ethanol extracts on blood pressure, renin-angiotensin system (RAS), and aortic lesion in spontaneously hypertensive rats. A group of WKY (normal) and six groups of spontaneously hypertensive rats were administered with saline (SHR), 50 mg/kg of captopril (CAP), 250 and 500 mg/kg of black soybean extracts (BE250 and BE500), 250 and 500 mg/kg of adzuki bean extracts (AE250 and AE500) for eight weeks. BE250, BE500, AE250, and AE500 significantly (p < 0.05) reduced relative liver weight, AST, ALT, triglyceride, total cholesterol, systolic blood pressure, and angiotensin-converting-enzyme level compared to SHR. The angiotensin II level in AE500 and renin mRNA expression in BE500 and AE500 were significantly (p < 0.05) decreased compared to SHR. The lumen diameter was significantly (p < 0.05) reduced in only CAP. Furthermore, systolic and diastolic blood pressure and angiotensin II level in AE500 were lower than those of BE500. These results suggest that AE exhibit more antihypertensive potential than BE in spontaneously hypertensive rats.

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Section: Methodsmentioning

confidence: 99%

Black Soybean and Adzuki Bean Extracts Lower Blood Pressure by Modulating the Renin-Angiotensin System in Spontaneously Hypertensive Rats

Jeong

Yang

Baek

et al. 2021

Foods

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“…Fermented foods, such as dairy, fruits and vegetable-based fermented food, contain bacteria with probable probiotic effects [ 91 ]. Experimental studies show that fermented foods may mitigate many complications associated with CKD progression and gut dysbiosis [ 92 , 93 , 94 ]. It is likely that salutogenic bioactive compounds naturally present in foods or those derived from the fermentation process (bactericins, exopolysaccharides and SCFA, among others) also contribute.…”

Section: Gut Microbiota Modulation and Effects On Residual Kidney Fun...mentioning

confidence: 99%

Gut Microbiota Interventions to Retain Residual Kidney Function

Mafra

Kemp

Borges

et al. 2023

Toxins

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Residual kidney function for patients with chronic kidney disease (CKD) is associated with better quality of life and outcome; thus, strategies should be implemented to preserve kidney function. Among the multiple causes that promote kidney damage, gut dysbiosis due to increased uremic toxin production and endotoxemia need attention. Several strategies have been proposed to modulate the gut microbiota in these patients, and diet has gained increasing attention in recent years since it is the primary driver of gut dysbiosis. In addition, medications and faecal transplantation may be valid strategies. Modifying gut microbiota composition may mitigate chronic kidney damage and preserve residual kidney function. Although various studies have shown the influential role of diet in modulating gut microbiota composition, the effects of this modulation on residual kidney function remain limited. This review discusses the role of gut microbiota metabolism on residual kidney function and vice versa and how we could preserve the residual kidney function by modulating the gut microbiota balance.

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Blended extract of oat, sorghum, adzuki bean, finger millet, and proso millet improved hyperglycemia and insulin resistance in the streptozotocin–nicotinamide-induced diabetic rats

Yang

Jeong

Baek

et al. 2023

Food Sci Biotechnol

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Effects of fermented red bean extract on nephropathy in streptozocin-induced diabetic rats

Cited by 8 publications

References 46 publications

Black Soybean and Adzuki Bean Extracts Lower Blood Pressure by Modulating the Renin-Angiotensin System in Spontaneously Hypertensive Rats

Black Soybean and Adzuki Bean Extracts Lower Blood Pressure by Modulating the Renin-Angiotensin System in Spontaneously Hypertensive Rats

Gut Microbiota Interventions to Retain Residual Kidney Function

Blended extract of oat, sorghum, adzuki bean, finger millet, and proso millet improved hyperglycemia and insulin resistance in the streptozotocin–nicotinamide-induced diabetic rats

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