Effects of Fentanyl and Sufentanil on Peripheral Mammalian Nerves

Gissen, Aaron J.; Gugino, Laverne D.; Datta, Sanjay; Miller, J. C.; Covino, Benjamín G.

doi:10.1213/00000539-198712000-00012

Cited by 136 publications

(79 citation statements)

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“…The reasons why fentanyl was unable to improve the analgesia of the TAP block are unclear. One plausible explanation may be that fentanyl was unable to diffuse through the nerve sheath (8). In addition, the median time to first PCA was markedly shorter in the present study, as compared with those reported in previous studies, including 220 min (150-380 min) (2), 3 h (inter-quartile range, 1 h) (3) and 4 h (0.5-29 h) (4).…”

Section: Discussioncontrasting

confidence: 56%

“…The existence of opioid receptors at peripheral nerves and the LA-like action of various opioids, including fentanyl and sufentanil, have been demonstrated in vitro (6,8); however, there has been controversy regarding the efficacy of the perineural application of opioids in clinical trials. Murphy et al (24) reported that opioids had limited benefits as analgesic adjuncts to the brachial plexus block, whereas they were shown to exert a definite but mild analgesia following intraarticular injection in another study (25).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, various opioids, including fentanyl and sufentanil, have been shown to exert LA-like effects (8). However, the effects of opioids on peripheral nerve blocks are controversial; previous studies have reported both positive and negative effects for opioids (9)(10)(11)(12)(13)(14)(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Addition of fentanyl to the ultrasound-guided transversus abdominis plane block does not improve analgesia following cesarean delivery

Wang¹,

Liu²,

Zhang³

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to investigate whether the addition of fentanyl to the transversus abdominis plane (TAP) block procedure may improve analgesic duration following cesarean delivery. A total of 147 nulliparous women with an American Society of Anesthesiologists physical status I-II, scheduled for elective cesarean delivery under spinal anesthesia, were enrolled in the present study. All patients underwent cesarean delivery under spinal anesthesia with 10 mg bupivacaine and 10 µg fentanyl, after which the patients underwent an ultrasound-guided bilateral TAP block with either 0.375% ropivacaine (group T R ; n=48), 0.375% ropivacaine and 50 µg subcutaneous fentanyl (group T R S F ; n=49), or a mixture of 0.375% ropivacaine and 50 µg fentanyl (2.5 µg/ml; group T RF ; n=50) per side. The TAP block formed part of a multimodal analgesic regimen comprising patient-controlled analgesia (PCA) with intravenous fentanyl, and regular treatment with diclofenac and paracetamol. The TAP block was performed in the midaxillary line using an in-plane technique. The primary outcome was the time to the first PCA, whereas secondary outcomes were the cumulative and interval PCA consumptions, visual analogue scale (VAS) pain scores at rest and during movement, side effects assessed at 2, 6, 12, 24 and 48 h postoperatively, and patient satisfaction with postoperative analgesia. No significant differences were observed in the median time to the first PCA among the three groups (P=0.640), which were 150 min (70-720 min) in group T R , 165 min (90-670 min) in group T R S F , and 190 min (70-680 min) in group T RF . Fentanyl consumption, VAS pain scores, side effects and patient satisfaction were similar among the three groups; however, the demand for fentanyl was significantly decreased in the T R S F and T RF groups at 2 h postoperatively (P=0.001 and 0.002, respectively), as compared with group T R . No complications attributed to the TAP block were detected. In conclusion, the results of the present study suggested that the addition of 2.5 µg/ml fentanyl to the TAP block procedure was unable to improve analgesia following cesarean delivery under spinal anesthesia.

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Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

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Addition of fentanyl to the ultrasound-guided transversus abdominis plane block does not improve analgesia following cesarean delivery

Wang¹,

Liu²,

Zhang³

et al. 2016

Experimental and Therapeutic Medicine

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show abstract

“…Evidences have begun to support the presence of peripheral opioid receptors. 10,11,12,13,14 So the possible mechanism of prolonged analgesia by peripheral opioid administration could be through direct binding at opioid receptors of dorsal nerve root aided by axonal flow, diffusion through brachial plexus sheath to extradural or subarachnoid space to dorsal horn and central action after peripheral systemic uptake. 15 Fentanyl, a phenylpiperidine derivative, is known to produce antinociception and enhance the effect of local anaesthetics when given epidurally or intrathecally.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study Between Bupivacaine Alone and Bupivacaine With Fentanyl in Axillary Plexus Block for Upper Limb Surgeries

P.V¹,

T²

2018

jebmh

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BACKGROUNDThe addition of adjuncts like Neostigmine, opioids, midazolam, dexmedetomidine, hyaluronidase, clonidine etc., to local anaesthetics for brachial plexus block may enhance the quality and duration of analgesia. Fentanyl, a phenylpiperidine derivative, is known to produce antinociception and enhance the effect of local anaesthetics when given epidurally or intrathecally. The purpose of the present study is to assess the effect of fentanyl added to brachial plexus block by axillary approach.

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“…Further, in combination with lidocaine, sufentanil does neither potentiate nor prolong the analgesic effect of lidocaine. [1][2][3][4] Furthermore, in an isolated sheathed and desheathed rabbit vagus nerve preparation, high concentrations of opioids have been shown to exert a weak local anesthetic-type action, 5 and recent investigations suggest the existence of opioid receptors mediating analgesia on the peripheral terminals of afferent nerves. [6][7][8][9][10] The analgesic effects of peripherally applied opioids, which may be reversed with an opioid antagonist such as naloxone 7 are especially prominent in inflamed tissue.…”

mentioning

confidence: 99%

L’administration intradermique de sufentanil n’améliore pas l’anesthésie locale induite par la lidocaïne

Hartmannsgruber

Atanassoff

Budde

et al. 2003

Can J Anesth/J Can Anesth

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Effects of Fentanyl and Sufentanil on Peripheral Mammalian Nerves

Cited by 136 publications

References 0 publications

Addition of fentanyl to the ultrasound-guided transversus abdominis plane block does not improve analgesia following cesarean delivery

Addition of fentanyl to the ultrasound-guided transversus abdominis plane block does not improve analgesia following cesarean delivery

Comparative Study Between Bupivacaine Alone and Bupivacaine With Fentanyl in Axillary Plexus Block for Upper Limb Surgeries

L’administration intradermique de sufentanil n’améliore pas l’anesthésie locale induite par la lidocaïne

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