Effects of fenfluramine, 8-OH-DPAT, and tryptophan-enriched diet on the high-ethanol intake by rats bred for susceptibility to stress

West, Charles H.K.; Boss-Williams, Katherine A.; Weiss, Jay M.

doi:10.1016/j.alcohol.2011.07.007

Cited by 4 publications

(4 citation statements)

References 54 publications

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“…Major concurrent measures would include body weight as well as food and water intake to detect secondary effects. Examples of neurotransmitters modulating the maintenance of ethanol intake include the adrenergic (alpha: Froehlich et al, 2013a), cannabinoid (Dyr et al, 2008; Gessa et al, 2005; Hansson et al, 2007), cholinergic (Bell et al, 2009a; Sotomayor-Zarate et al, 2013), dopaminergic (Dyr et al, 1993; Thanos et al, 2005), GABAergic (GABRA: Agabio et al, 1998; GABRA-BDZ complex: June et al,1998b; McKay et al, 2004; GABRB: Maccioni et al, 2012; Quintanilla et al, 2008), glutamatergic (Bilbeny et al, 2005; Cowen et al, 2005b; Sari et al, 2013a), histaminergic (Lintunen et al, 2001), opioid (pan-opioid: Hyytiä and Sinclair, 1993; June et al, 1998d; MOR: Honkanen et al, 1996; Krishnan-Sarin et al, 1998; DOR: Hyytiä and Kiianmaa, 2001; sigma: Sabino et al, 2009a), and serotonergic (Long et al, 1996; Overstreet et al, 1997; Panocka et al, 1995b; West et al, 2011) systems (Table 5). Overall, the neurotransmitter systems most often tested across the lines have been the (a) cannabinoid system in six of the selectively bred rat lines, (b) GABAergic system in five of the selectively bred lines as well as Sprague-Dawley and Long-Evans Hooded outbred lines, and (c) opioid system in six of the selectively bred rat lines as well as Sprague-Dawley and Wistar outbred lines.…”

Section: Behavioral Models For Screening Treatment Compounds And/omentioning

confidence: 99%

Rat animal models for screening medications to treat alcohol use disorders

et al. 2017

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The purpose of this review is to present animal research models that can be used to screen and/or repurpose medications for the treatment of alcohol abuse and dependence. The focus will be on rats and in particular selectively bred rats. Brief introductions discuss various aspects of the clinical picture, which provide characteristics of individuals with alcohol use disorders (AUDs) to model in animals. Following this, multiple selectively bred rat lines will be described and evaluated in the context of animal models used to screen medications to treat AUDs. Next, common behavioral tests for drug efficacy will be discussed particularly as they relate to stages in the addiction cycle. Tables highlighting studies that have tested the effects of compounds using the respective techniques are included. Wherever possible the Tables are organized chronologically in ascending order to describe changes in the focus of research on AUDs over time. In general, high ethanol-consuming selectively bred rats have been used to test a wide range of compounds. Older studies usually followed neurobiological findings in the selected lines that supported an association with a propensity for high ethanol intake. Most of these tests evaluated the compound's effects on the maintenance of ethanol drinking. Very few compounds have been tested during ethanol-seeking and/or relapse and fewer still have assessed their effects during the acquisition of AUDs. Overall, while a substantial number of neurotransmitter and neuromodulatory system targets have been assessed; the roles of sex- and age-of-animal, as well as the acquisition of AUDs, ethanol-seeking and relapse continue to be factors and behaviors needing further study.

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Section: Behavioral Models For Screening Treatment Compounds And/omentioning

confidence: 99%

Rat animal models for screening medications to treat alcohol use disorders

et al. 2017

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“…In the case of the RES rat, this divergence perhaps may be explained by previously discovered differences in dopamine physiology that are present in forebrain regions of RES rats relative to SUS rats. Relative to SUS rats, RES rats show considerably higher levels of dopamine (DA) and metabolites in forebrain regions, pointing to increased synthesis of DA, and increased DA release particularly by mesocorticolimbic neurons, both at baseline and in response to stress [10,25]. Insofar as forebrain DA neurotransmission promotes motor activity, this hyperdopaminergic response of RES rats is likely to account for why they are resistant to stress-induced decreased in forced swim activity and also why they show increased motor behavior in the open field after adolescent stress (Fig.…”

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confidence: 99%

Sex and lineage interact to predict behavioral effects of chronic adolescent stress in rats

Harrell

Hardy

Boss-Williams

et al. 2013

Behavioural Brain Research

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Neuropsychiatric disorders often derive from environmental influences that occur at important stages of development and interact with genetics. This study examined the effects of stress during adolescence in rats selectively bred for different behavioral responses to stress. The effects of chronic adolescent stress were compared between rats selected for susceptibility to reduced activity following acute stress (Swim-test Susceptible rats) and rats resistant to activity reduction after acute stress (Swim-test Resistant rats). Consistent with lineage, exposure to chronic adolescent stress increased swim-test activity of the Swim-test Resistant rats while tending to reduce activity of the Swim-test Susceptible rats. Consistent with the increased activity demonstrated post-stress in the swim test, chronic adolescent stress increased total activity in the open field for Swim-test Resistant rats. Indicative of anhedonia, chronic adolescent stress exposure decreased sucrose consumption in both male and female Swim-test Resistant rats but only in female Swim-test Susceptible rats. Although chronic stress induced changes in behavior across both breeding lines, the precise manifestation of the behavioral change was dependent on both breeding line and sex. Collectively, these data indicate that selective breeding interacts with chronic stress exposure during adolescence to dictate behavioral outcomes.

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“…This k-opioid receptor agonist has been found to reduce consumption in rats with simulated injuries and a high preference for alcohol [ 95 ]. In addition, increasing alcohol consumption in low doses and decreasing it in high doses in rats and squirrel monkeys (Saimiri sciureus) depending on the dose [ 96 , 97 ]. In humans, administration of morphine [ 98 ] and codeine [ 99 ] have been found to increase aggressive behaviour.…”

Section: Discussionmentioning

confidence: 99%

The Role of Social Stress in the Development of Inhibitory Control Deficit: A Systematic Review in Preclinical Models

Sánchez-Salvador

Prados-Pardo

Martín-González

et al. 2021

IJERPH

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Inhibitory control deficit and impulsivity and compulsivity behaviours are present in different psychopathological disorders such as addiction, obsessive-compulsive disorders and schizophrenia, among others. Social relationships in humans and animals are governed by social organization rules, which modulate inhibitory control and coping strategies against stress. Social stress is associated with compulsive alcohol and drug use, pointing towards a determining factor in an increased vulnerability to inhibitory control deficit. The goal of the present review is to assess the implication of social stress and dominance on the vulnerability to develop impulsive and/or compulsive spectrum disorders, with the aid of the information provided by animal models. A systematic search strategy was carried out on the PubMed and Web of Science databases, and the most relevant information was structured in the text and tables. A total of 34 studies were recruited in the qualitative synthesis. The results show the role of social stress and dominance in increased drug and alcohol use, aggressive and impulsive behaviour. Moreover, the revised studies support the role of Dopaminergic (DA) activity and the alterations in the dopaminergic D1/D2 receptors as key factors in the development of inhibitory control deficit by social stress.

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Effects of fenfluramine, 8-OH-DPAT, and tryptophan-enriched diet on the high-ethanol intake by rats bred for susceptibility to stress

Cited by 4 publications

References 54 publications

Rat animal models for screening medications to treat alcohol use disorders

Rat animal models for screening medications to treat alcohol use disorders

Sex and lineage interact to predict behavioral effects of chronic adolescent stress in rats

The Role of Social Stress in the Development of Inhibitory Control Deficit: A Systematic Review in Preclinical Models

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