Effects of female and male smoking on success rates of IVF and gamete intra-Fallopian transfer

Klonoff-Cohen, Hillary; Natarajan, Loki; Marrs, Richard P.; Yee, Bill

doi:10.1093/humrep/16.7.1382

Cited by 126 publications

(76 citation statements)

References 24 publications

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“…However, the lower peak E2 levels [21,22] and recruitment of fewer follicles and oocytes [7,13,15,21,23,24] in smokers that were reported in earlier studies were not observed in our population, in which milder and less vigorous stimulation was required.…”

Section: Discussioncontrasting

confidence: 79%

“…Several meta-analyses and reviews have investigated the effect of smoking in patients undergoing IVF treatment [5][6][7]. They all found that compared to nonsmokers, smokers required a higher mean gonadotropin doses for ovarian stimulation, and had lower peak E2 levels, fewer oocytes retrieved, lower fertilization and implantation rates, and lower pregnancy and live-birth rates.…”

Section: Introductionmentioning

confidence: 99%

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Influence of smoking on outcome of COH and IUI in subfertile couples

Farhi

Orvieto

2009

J Assist Reprod Genet

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Aim To evaluate the influence of smoking on the outcome of COH and IUI in subfertile couples. Patients and methods We reviewed the medical files of all consecutive women, age ≤35 years, attending our infertility clinics over an eigth-year period. Data on patient age, smoking habits, and variable related to infertility-treatment were collected from the files. Results A total of 2,318 cases were evaluated: 1,803 in nonsmoking patients (n=679) and 515 in smokers (n=206). The smokers used significantly more gonadotropin ampoules and gained a thinner endometrium on the day of hCG administration than the nonsmokers (p<0.016 for both). There were no between-groups differences in patient age, duration of gonadotropin stimulation, number of follicle >14 mm in diameter, or E2 levels on the day of hCG administration. Conclusion Smokers undergoing COH with IUI required a significantly higher gonadotropin dosage than nonsmokers in order to achieved a comparable pregnancy rate.

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Section: Discussioncontrasting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Influence of smoking on outcome of COH and IUI in subfertile couples

Farhi

Orvieto

2009

J Assist Reprod Genet

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“…A meta-analysis of 2,314 first IVF cycles from eight studies showed that odds of pregnancy were almost halved by smoking [48]. In another study, couples (one or both) who ever smoked had an adjusted relative rate, RR, of 2.41 of not achieving an IVF pregnancy and 3.76 of not achieving a live birth [49]. Moreover, couples smoking more than 5 years had a RR of 4.27 of not achieving a pregnancy.…”

Section: Risks Associated With the Culture Of Gametes And Embryosmentioning

confidence: 99%

What are the risks of the assisted reproductive technologies (ART) and how can they be minimized?

Rebar

2013

Reprod Medicine & Biology

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Although assisted reproductive technologies (ART) have become established procedures performed around the world, there are still many unanswered questions regarding safety. Possible risks associated with infertility and ART include (1) those inherent to pregnancy, delivery, and childhood; (2) those associated with the infertility itself and its causes; and (3) risks iatrogenic to ART. Although there are many potential risks associated with ART, it has become clear that the major risk is multiple pregnancy and its consequences. Major efforts are warranted to reduce the risk of multiple gestations with IVF, but it is also clear that single-embryo transfer is not the solution in all cases. Moreover, several studies have now documented that perinatal outcomes are somewhat poorer in IVF singleton infants than in spontaneously conceived singletons, but it is not clear if this increased risk is due to the ART or the infertility. Concerns about the impact of abnormalities in genomic imprinting persist at this time, as do risks associated with the culture conditions and even our environment. Only time will tell if children born following ART are at any increased risk of developing certain chronic diseases as they age. In any case, the risks to IVF children and mothers are likely to remain higher than those for children and mothers conceived spontaneously without medical assistance. However, since there have been over 5 million births after ART worldwide, and the vast majority of pregnancies and children have been essentially ''normal'', it is obvious that any excess risk must be relatively small. The normality of most pregnancies mandates that extreme care be exercised in making any changes to current practice.

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“…Additionally, various physical, occupational, behavioural and socio-economic factors affecting human fertility in men and women may also influence success of the IVF treatment [8][9][10][11][12][13]. Obesity and smoking are thought to be some of the most critical among these factors [4][5][6][7][8][9][10][11][12][13][14][15][16]. It has also been established that some drugs, heavy metals and solvents, may affect fertility [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Demographic characteristics and AMH levels in rural and urban women participating in an IVF programme

Kunicki¹,

Łukaszuk²,

Liss³

et al. 2018

Ann Agric Environ Med.

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Objective. The primary aim of this preliminary study was to compare the IVF results of couples living in rural and urban areas. Additionally, the ovarian reserve parameters, such as AMH concentrations, were compared for the same groups. Materials and method. The database of 1,265 women undergoing in vitro fertilization at the Invicta Fertility Center between May 2011-July 2012 were retrospectively analyzed. Women undergoing their first assisted reproductive technology cycle with ICSI, stimulated according to the long protocol, and whose AMH levels were measured using the same DSL kit, were selected. Ultimately, 651 women were included in the study. All participants were categorized based on the area where they live: rural areas, small towns (<100,000 inhabitants) and large cities (>100,000) Results. The mean age of the patients living in large cities was significantly higher in comparison to those from rural areas and small towns. A significantly higher pregnancy body mass index (BMI) was found in women from rural areas in comparison to the women living in small and large towns. Serum AMH and inhibin B concentrations, number of ampules of gonadotropins, and antral follicle count (AFC), did not differ significantly among the groups. The study showed no significant differences among the groups in terms of clinical pregnancy rate, both per started cycle and per embryo transfer. Conclusions. No significant differences were found in IVF outcomes among the groups inhabiting rural areas, small and large cities.

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Effects of female and male smoking on success rates of IVF and gamete intra-Fallopian transfer

Abstract: There is compelling evidence that couples should be made aware that smoking years before undergoing IVF and GIFT can impact treatment outcome. This study may also provide insight into the timing and effects of male and female smoking on natural reproduction.

Cited by 126 publications

References 24 publications

Influence of smoking on outcome of COH and IUI in subfertile couples

Influence of smoking on outcome of COH and IUI in subfertile couples

What are the risks of the assisted reproductive technologies (ART) and how can they be minimized?

Demographic characteristics and AMH levels in rural and urban women participating in an IVF programme

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