Effects of feeding outer bran fraction of rice on lipid accumulation and fecal excretion in rats

Ijiri, Daichi; Nojima, Tsutomu; Kawaguchi, Mana; Yamauchi, Yoko; Fujita, Yoshikazu; Ijiri, Satoru; Ohtsuka, Akira

doi:10.1080/09168451.2015.1032883

Cited by 7 publications

(7 citation statements)

References 36 publications

(41 reference statements)

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“…In addition, although most nutrients are absorbed in the small intestine, some fat does reach the colon. About 5% of dietary fats are excreted in feces, and increased dietary saturated fat or dietary fiber increases fat excretion (115, 116). Colon does have nutrient absorptive capacity (117, 118), and it is possible that diet affects absorption of bacterial products in the colon as well as in the small intestine.…”

Section: Diet Modulates Absorption Of Bacterial Componentsmentioning

confidence: 99%

Obesity-associated cancer risk: the role of intestinal microbiota in the etiology of the host proinflammatory state

Djurić

2017

Translational Research

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Obesity increases the risks of many cancers. One important mechanism behind this association is the obesity-associated pro-inflammatory state. Although the composition of the intestinal microbiome undoubtedly can contribute to the pro-inflammatory state, perhaps the most important aspect of host-microbiome interactions is host exposure to components of intestinal bacteria that stimulate the inflammatory reactions. Systemic exposures to intestinal bacteria can be modulated by dietary factors by altering both the composition of the intestinal microbiota as well as absorption of bacterial products from the intestinal lumen. In particular, high fat and high energy diets have been shown to facilitate absorption of bacterial lipopolysaccharide (LPS) from intestinal bacteria. Biomarkers of bacterial exposures that have been measured in blood include LPS-binding protein, sCD14, fatty acids characteristic of intestinal bacteria and immunoglobulins specific for bacterial LPS and flagellin. The optimal strategies to reduce these pro-inflammatory exposures, whether by altering diet composition, avoiding a positive energy balance or reducing adipose stores, likely differ in each individual. Biomarkers that assess systemic bacterial exposures therefore should be useful to optimize and personalize preventive approaches for individuals and groups with specific characteristics, and to gain insight into the possible mechanisms involved with different preventive approaches.

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Section: Diet Modulates Absorption Of Bacterial Componentsmentioning

confidence: 99%

Obesity-associated cancer risk: the role of intestinal microbiota in the etiology of the host proinflammatory state

Djurić

2017

Translational Research

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“…In line with this, the study showed the differences in the quantities of some of these bioactive compounds that have hypolipidemic effects. Studies have illustrated that the higher the γ-oryzanol, phytosterols, and fibers present in the rice grain, the better the hypolipidemic effects and the ability to inhibit the enzyme responsible for cholesterol synthesis ( 23 ). Also, an increase in the γ-oryzanol content brought about by germination further lowers the lipid profile of the OVX rats by inhibiting cholesterol absorption in the intestines, and thus also increasing fecal cholesterol excretion ( 22 ).…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation of germinated pigmented rice (Oryza sativaL.) lowers dyslipidemia risk in ovariectomized Sprague–Dawley rats

Kang

et al. 2016

Food & Nutrition Research

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BackgroundIn the recent years, cases of elderly women suffering from metabolic diseases such as dyslipidemias brought about by hormonal imbalance after menopause are continuously increasing. In this regard, a continuous and escalating demand to develop a more functional and highly nutritional food product as an adjunct supplement that can help alleviate these diseases is still being sought.ObjectiveThis study investigated the effects of germinated blackish-purple rice cultivars Keunnunjami, Superjami, and reddish-brown cultivar Superhongmi in the lipid metabolism of ovariectomized Sprague–Dawley rats.MethodThe animals were randomly divided into nine groups (n=5) and were supplemented with either non-germinated or germinated rice for 9 weeks. Then the plasma, liver, and fat samples were collected for the lipid metabolism effects analyses.ResultsAnimals fed with germinated rice cultivars had improved lipid profile levels relative to the groups supplemented with non-germinated rice cultivars. The germinated rice groups, Keununjami and Superjami in particular, showed a low total cholesterol levels, high levels of high-density lipoproteins-cholesterol, high fecal lipid output, low hepatic lipid values, and low hepatic adipocyte accumulation. There was also an increase in the rate of lipolysis and decrease in lipogenesis based on the lipid-regulating enzyme activity profiles obtained for the groups that fed on germinated rice. Also, results revealed that pigmented rice cultivars had superior effects in improving the lipid metabolism relative to the non-pigmented normal brown rice variety.ConclusionBased on the results, this study suggests that germinated pigmented rice consumption can confer better lipid metabolism than ordinary white rice and constitutes as an effective functional food in alleviating the risk of having dyslipidemias like those suffering from menopausal co-morbidities.

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“…A control diet (AIN-93G) and a diet containing 5% OBFR were prepared in advance for use in the study. OBFR was collected as previously described [6]. The crude protein (CP), neutral detergent fiber (NDF), and gross energy (GE) components of the two diets were designed to be equal.…”

Section: Diet Preparationmentioning

confidence: 99%

“…Interestingly, ingesting insoluble fiber has been found to reduce energy digestibility, body weight gain, or blood lipid levels in animals, e.g., feeding a dietary fiber-rich by-product of the soy milk industry to healthy rats for 4 weeks showed decreases in weight gain and serum total cholesterol level [5]. In addition, we previously found that feeding the outer bran fractions of rice (OBFR) to rats for 3 weeks enhanced fecal lipid excretion, and consequently reduced abdominal lipid accumulation [6].…”

Section: Introductionmentioning

confidence: 97%

“…The outer layer of rice bran mainly consists of the pericarp, which is richer in lignin than the inner layer, while the amounts of pectic substances, hemicellulose, and α-cellulose are approximately equal in the inner and outer layers [17]. In a previous study, we collected the OBFR from the first and second breaks of a commercial quadruple-break milling system and found that the OBFR contains γ-oryzanol and phytic acid at 1.2-fold higher abundance than whole rice bran [6]. The aim of the current study is to examine the effects of dietary OBFR on the intestinal environment and plasma, hepatic, and cecal metabolite profiles of rats.…”

Section: Introductionmentioning

confidence: 99%

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Feeding the Outer Bran Fraction of Rice Alters Hepatic Carbohydrate Metabolism in Rats

et al. 2020

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Dietary intake of fiber-rich food has been reported to contribute to multiple health benefits. The aim of the current study is to investigate the effects of a diet containing the outer bran fraction of rice (OBFR), which is rich in insoluble fiber, on the intestinal environment and metabolite profiles of rats. Fourteen 8-week-old male Sprague–Dawley rats were divided into a control group and an OBFR group. For a period of 21 days, the control group was fed a control diet, while the OBFR group was fed a diet containing 5% OBFR. Metabolomics analysis revealed drastic changes in the cecal metabolites of the rats fed the OBFR diet. Furthermore, in the plasma and liver tissue, the concentrations of metabolites involved in pyruvate metabolism, the pentose phosphate pathway, gluconeogenesis, or valine, leucine, isoleucine degradation were changed. Concordantly, the OBFR diet increased the expression of genes encoding enzymes involved in these metabolic pathways in the livers of the rats. Collectively, these results suggest that the OBFR diet altered the concentrations of metabolites in the cecal contents, plasma, and liver, and the hepatic gene expressions of rats, and that this may have mainly contributed to carbohydrate metabolism in the liver.

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Effects of feeding outer bran fraction of rice on lipid accumulation and fecal excretion in rats

Cited by 7 publications

References 36 publications

Obesity-associated cancer risk: the role of intestinal microbiota in the etiology of the host proinflammatory state

Obesity-associated cancer risk: the role of intestinal microbiota in the etiology of the host proinflammatory state

Dietary supplementation of germinated pigmented rice (Oryza sativaL.) lowers dyslipidemia risk in ovariectomized Sprague–Dawley rats

Feeding the Outer Bran Fraction of Rice Alters Hepatic Carbohydrate Metabolism in Rats

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