Effects of feeding aspirin and supplemental vitamin E on plasma concentrations of 3-methylindole, 3-methyleneindolenine-adduct concentrations in blood and pulmonary tissues, lung lesions, and growth performance in feedlot cattle

Loneragan, Guy H.; Morley, Paul S.; Wagner, John J.; Mason, Gary L.; Yost, Garold S.; Wittum, Thomas E.; Bray, Tammy M.

doi:10.2460/ajvr.2002.63.1641

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Therapeutic Options1

-Methylindole As a Cause Of Acute Interstitial Pneumonia1

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2009

2022

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Cited by 7 publications

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“…31,33 It has been claimed, however, that aspirin treatment of cattle with clinical signs of AIP is associated with longer survival. 34 Removal of MGA from the diets of heifers has been reported to decrease rates of AIP.…”

Section: Therapeutic Optionsmentioning

confidence: 97%

Feedlot Acute Interstitial Pneumonia

Woolums

2015

Veterinary Clinics of North America: Food Animal Practice

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Section: Therapeutic Optionsmentioning

confidence: 97%

Feedlot Acute Interstitial Pneumonia

Woolums

2015

Veterinary Clinics of North America: Food Animal Practice

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“…In keeping with this, in an experimental setting, PHS inhibitors – such as aspirin – appeared to be protective against AIP when administered prior to, but not after, intravenous injection of 3-MI (Acton et al ., 1992). However, this effect has proven difficult to replicate in a clinical setting (Loneragan et al ., 2002). Clearly, further work is needed to characterise the respective contributions of PHS and CYP450s to AIP pathogenesis.…”

Section: -Methylindole As a Cause Of Acute Interstitial Pneumoniamentioning

confidence: 99%

Acute interstitial pneumonia and the biology of 3-methylindole in feedlot cattle

Haydock

Fenton

Sergejewich

et al. 2022

Anim. Health. Res. Rev.

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Acute interstitial pneumonia (AIP) of cattle has been recognized for many decades. While the pathogenesis and risk factors for this condition in pastured cattle are relatively well characterized, there remains a poor understanding of the disease as it occurs in intensively fed cattle such as in beef feedlots. Specifically, in pastured cattle, AIP results from excessive ruminal production of the pneumotoxicant 3-methylindole (3-MI). In feedlot cattle, the evidence to substantiate the role of 3-MI is comparatively deficient and further investigations into the cause, pathogenesis, and control are sorely needed. This review highlights our current understanding of AIP with a focus on the disease as it occurs in feedlot cattle. Additionally, it illustrates the need for further work in understanding the specific animal factors (e.g. the ruminal microbiome, and the role of concurrent diseases), management factors (e.g. animal stocking and vaccination protocols), and dietary factors (e.g. dietary supplements) that may impact the development of AIP and which are relatively unique to the feedlot setting. All stakeholders in the beef industry stand to benefit from a greater understanding of what remains a pressing yet poorly understood issue in beef production.

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