“…In addition, it is generally regarded as a high qualified food because it contains high protein content and low fat content. Therefore, this species has been a fantastic potential for the extensive artificial culture [1] , [2] , [3] ; however, with the rapid and high intensive development in the culture, an increasing number of bacterial infections that could cause severe diseases in cuttlefish have been reported, leading to the destructive consequences in its breeding and culture. V. alginolyticus , a bacterium that is ubiquitously present in the marine environment [4] , had been identified as a pathogen closely associated with skin ulcer disease during cuttlefish culture in our previous study [ 1 , 5 , 6 ].…”