Effects of FB1 and HFB1 on Autonomous Exploratory and Spatial Memory and Learning Abilities in Mice

Yang, Diaodiao; Ye, Yongli; Huang, Yaoguang; Huang, Heyang; Sun, Jiadi; Wang, Jia-Sheng; Tang, Lili; Gao, Yahui; Sun, Xiulan

doi:10.1021/acs.jafc.3c05501

Cited by 4 publications

(1 citation statement)

References 49 publications

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“…Fumonisins (FUMs) are water-soluble mycotoxins released by Fusarium spp , which commonly exist in corn (Dopavogui et al 2023 ; Yang et al 2023 ). However, fumonisin B1 (FB1) is the most toxic one of the fumonisins and causes serious harm to both human and animal health (Chen et al 2023 ; Ezekiel et al 2022 ; Yu et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Mild endoplasmic reticulum stress alleviates FB1-triggered intestinal pyroptosis via the Sec62-PERK pathway

Ma,

Li,

Yue

et al. 2024

Cell Biol Toxicol

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Fumonisin B1 (FB1), a water-soluble mycotoxin released by Fusarium moniliforme Sheld, is widely present in corn and its derivative products, and seriously endangers human life and health. Recent studies have reported that FB1 can lead to pyroptosis, however, the mechanisms by which FB1-induced pyroptosis remain indistinct. In the present study, we aim to investigate the mechanisms of pyroptosis in intestinal porcine epithelial cells (IPEC-J2) and the relationship between FB1-induced endoplasmic reticulum stress (ERS) and pyroptosis. Our experimental results showed that the pyroptosis protein indicators in IPEC-J2 were significantly increased after exposure to FB1. The ERS markers, including glucose-regulated Protein 78 (GRP78), PKR-like ER kinase protein (PERK), and preprotein translocation factor (Sec62) were also significantly increased. Using small interfering RNA silencing of PERK or Sec62, the results demonstrated that upregulation of Sec62 activates the PERK pathway, and activation of the PERK signaling pathway is upstream of FB1-induced pyroptosis. After using the ERS inhibitor 4-PBA reduced the FB1-triggered intestinal injury by the Sec62-PERK pathway. In conclusion, we found that FB1 induced pyroptosis by upregulating Sec62 to activate the PERK pathway, and mild ERS alleviates FB1-triggered damage. It all boils down to one fact, the study provides a new perspective for further, and improving the toxicological mechanism of FB1. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Mild endoplasmic reticulum stress alleviates FB1-triggered intestinal pyroptosis via the Sec62-PERK pathway

Ma,

Li,

Yue

et al. 2024

Cell Biol Toxicol

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HIF-1α is a “brake” in JNK-mediated activation of amyloid protein precursor and hyperphosphorylation of tau induced by T-2 toxin in BV2 cells

Zhao,

Valis,

Wang

et al. 2024

Mycotoxin Res

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Mycotoxins have the capacity of triggering neurodegenerative conditions like Alzheimer's disease (AD), which is marked by β-amyloid (Aβ) deposition and hyperphosphorylation of tau (P-tau). However, there is no evidence of an exact molecular mechanism to prove the above point. Due to the high toxicity and broad contamination of T-2 toxin, we assessed how T-2 toxin exposure alters amyloid precursor protein (APP) and P-tau formation in BV2 cells, and determined the underlying roles of HIF-1α and JNK3 signaling. The ndings revealed that T-2 toxin stimulated the expression of HIF-1α and hypoxic stress factors in addition to increasing the expression of APP and P-tau. Additionally, HIF-1α acted as a "brake" on the induction of APP and P-tau expression by negatively regulating these proteins. Notably, T-2 toxin activated JNK3 signaling, which broke this "brake" to promote the formation of APP and P-tau. Furthermore, the cytoskeleton was an essential target for T-2 toxin to exert cytotoxicity, and JNK3/HIF-1α participated in this damage. Collectively, when the T-2 toxin induces the production of APP and P-tau, JNK3 might interfere with HIF-1α's protective function. This study will provide clues for further research on the neurotoxicity of mycotoxins.

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Strong light-trapping probes with high antibody activity for sensitive detecting FB1 by “turn-on” lateral flow immunoassay

Yu,

Zhang,

et al. 2024

Chemical Engineering Journal

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Effects of FB1 and HFB1 on Autonomous Exploratory and Spatial Memory and Learning Abilities in Mice

Cited by 4 publications

References 49 publications

Mild endoplasmic reticulum stress alleviates FB1-triggered intestinal pyroptosis via the Sec62-PERK pathway

Mild endoplasmic reticulum stress alleviates FB1-triggered intestinal pyroptosis via the Sec62-PERK pathway

HIF-1α is a “brake” in JNK-mediated activation of amyloid protein precursor and hyperphosphorylation of tau induced by T-2 toxin in BV2 cells

Strong light-trapping probes with high antibody activity for sensitive detecting FB1 by “turn-on” lateral flow immunoassay

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