Effects of Fatty Acid Addition to Oil-in-water Emulsions Stabilized with Sucrose Fatty Acid Ester

Watanabe, T.; Kawai, Takeshi; Nonomura, Yoshiaki

doi:10.5650/jos.ess17097

Cited by 23 publications

(15 citation statements)

References 19 publications

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“…3), and no phase separation was observed in the formulation during storage at -4 ºC for 21 days, showing that silk protein could play an important role in the stability of the lipid particles from the conjunct of fatty acid esters. Watanabe (Watanabe et al 2018) showed that sucrose fatty acid esters with HLB = 5-7 were suitable for obtaining O/W emulsions. In addition, the creaming phenomenon was inhibited for 30 days or more when fatty acids with a linear saturated alkyl chain with 14 or more carbon atoms were added.…”

Section: Resultsmentioning

confidence: 99%

Development of an environmentally friendly formulation of silk fibroin associated with fatty acid from Astrocaryum murumuru Mart. fat, effective against larvae of the Aedes aegypti vector

Marinho

Neves

Jimenez

et al. 2021

Preprint

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The Aedes aegypti mosquito is a vector of several diseases, such as dengue, malaria and the Zika virus. Synthetic insecticides such as chlorpyrifos and chlorothalonil have been used for plague control, despite causing damage to the environment and to humans. It is therefore important to study natural active compounds with a low environmental impact. The present paper developed an environmentally friendly formulation of silk fibroin (SF) associated with fatty acid esters [ethyl (FAEE-SF), propyl (FAPE-SF) and butyl (FABE-SF)] from Astrocaryum murumuru Mart. fat, which was effective against Aedes aegypti 3th instar larvae. The FABE-SF nanoemulsion induced a higher mortality rate in the larvae of the A. aegypti after 48 h (LC50 = 18.92 µg / mL). The stabilities of the nanoemulsions were monitored for 21 days, and FABE-SF exhibited greater stability throughout the monitored period, with average particle, zeta and PDI values of around 217 ± 0.85 nm, -25.6 ± 3.24 mV and 0.338 ± 0.01, respectively. This paper reported the first effective action of fatty acid esters from A. murumuru Mart. associated with silk fibroin against A. aegypti. The FABE-SF solution also had a low hemolytic index, suggesting that treatment may be safe for animal and human use.

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Section: Resultsmentioning

confidence: 99%

Development of an environmentally friendly formulation of silk fibroin associated with fatty acid from Astrocaryum murumuru Mart. fat, effective against larvae of the Aedes aegypti vector

Marinho

Neves

Jimenez

et al. 2021

Preprint

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“…In this study, different types of SEs were used to determine the effects of hydrophilic-lipophilic balance (HLB) values on the development of colloidal drug delivery systems. As the degree of sucrose esterification and fatty acid chain length increased, the HLB value of SE became decreased [ 35 ]. SE Laurate 1695 that has a high HLB value of 16 and was able to produce a large region of NE with small droplet size distribution and uniformity.…”

Section: Resultsmentioning

confidence: 99%

Development and characterisation of ibuprofen-loaded nanoemulsion with enhanced oral bioavailability

Anuar

Sabri

Effendi

et al. 2020

Heliyon

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Lipophilic compounds constitute a majority of therapeutics in the pipeline of drug discovery. Despite possessing enhanced efficacy and permeability, some of these drugs suffer poor solubility necessitating the need of a suitable drug delivery system. Nanoemulsion is a drug delivery system that provides enhanced solubility for poorly soluble drugs in an attempt to improve the oral bioavailability. The purpose of this study is to develop a nanoemulsion system using ibuprofen as a model drug in order to investigate the potential of this colloidal system to enhance the absorption of poorly water-soluble drugs. Ibuprofen loaded-nanoemulsion with different drug concentrations (1.5, 3 and 6% w/w) were formulated from olive oil, sucrose ester L-1695 and glycerol using D-phase emulsification technique. A pseudoternary phase diagram was utilised to identify the optimal excipient composition to formulate the nanoemulsion system. In vitro diffusion chamber studies using rodent intestinal linings highlighted improved absorption profile when ibuprofen was delivered as nanoemulsion in comparison to microemulsions and drug-in-oil systems. This was further corroborated by in vivo studies using rat model that highlighted a two-fold increase in ibuprofen absorption when the drug was administered as a nanoemulsion relative to drug-in-oil system. On the other hand, when ibuprofen was administered as microemulsions, only a 1.5-fold increase in absorption was observed relative to drug-in-oil system. Thus, this study highlights the potential of using nanoemulsion as a drug delivery system to enhance the oral bioavailability of hydrophobic drugs.

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“…Meanwhile, sodium alginate’s properties have been used in chewing gum but not in extrusion [ 45 ]. New studies have shown that sodium alginate could be used in extrusion and could formulate microcapsules with essential oil as the core material [ 26 , 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…The primary emulsions for microcapsules were prepared similarly in all studies [ 23 , 26 , 33 ], including this study. Yet in this research, three different methods were used for group 5 emulsions ( Figure 1 ) to determine which method is the most effective and results in the highest CI.…”

Section: Resultsmentioning

confidence: 99%

“…It will be a new material in experiments with nutmeg essential oil (NEO)-loaded calcium alginate microcapsules, manufactured by using an extrusion method. Sucrose esters are white powders, soluble in water and frequently used in food or cosmetic industry [ 22 , 23 , 24 , 25 , 26 ], so it can be predicted that sucrose esters would work well in other areas, such as pharmaceuticals, when formulating drugs or nutritional supplements with essential oils or emulsions. Applying theoretical knowledge of this material, a new technology of nutmeg essential oil microencapsulation can be developed.…”

Section: Introductionmentioning

confidence: 99%

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Development of New Formula Microcapsules from Nutmeg Essential Oil Using Sucrose Esters and Magnesium Aluminometasilicate

2020

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Essential oils are volatile liquids which evaporate and lose their pharmacological effect when exposed to the environment. The aim of this study is to protect nutmeg essential oil from environmental factors by encapsulation (shell material, sodium alginate) and determine the influence of crosslinker concentration (2%, 5% calcium chloride), different emulsifiers (polysorbate 80, sucrose esters), and magnesium aluminometasilicate on microcapsule physical parameters, encapsulation efficiency (EE), swelling index (SI), and other parameters. Nutmeg essential oil (NEO)-loaded calcium alginate microcapsules were prepared by extrusion. The swelling test was performed with and without enzymes in simulated gastric, intestinal, and gastrointestinal media. This study shows that the crosslinker concentration has a significant influence on EE, with 2% calcium chloride solution being more effective than 5%, and capsules being softer with 2% crosslinker solution. Using sucrose esters, EE is higher when polysorbate 80 is used. The swelling index is nearly three times higher in an intestinal medium without enzymes than in the medium with pancreatin. Microcapsule physical parameters depend on the excipients: the hardest capsules were obtained with the biggest amount of sodium alginate; the largest with magnesium aluminometasilicate. Sucrose esters and magnesium aluminometasilicate are new materials used in extrusion.

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Effects of Fatty Acid Addition to Oil-in-water Emulsions Stabilized with Sucrose Fatty Acid Ester

Cited by 23 publications

References 19 publications

Development of an environmentally friendly formulation of silk fibroin associated with fatty acid from Astrocaryum murumuru Mart. fat, effective against larvae of the Aedes aegypti vector

Development of an environmentally friendly formulation of silk fibroin associated with fatty acid from Astrocaryum murumuru Mart. fat, effective against larvae of the Aedes aegypti vector

Development and characterisation of ibuprofen-loaded nanoemulsion with enhanced oral bioavailability

Development of New Formula Microcapsules from Nutmeg Essential Oil Using Sucrose Esters and Magnesium Aluminometasilicate

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