Effects of Falciparum Malaria Infection on Some Hematological Indices and Renal functions

Nwanjo, HU; Opara, Amoge

doi:10.4314/jmls.v14i1.35310

Cited by 6 publications

(9 citation statements)

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“…Our study showed lymphocytopenia in 97 children (53.3%). The study has further revealed that there were no statistically significant differences in granulocyte and lymphocyte counts between malaria-infected and noninfected children, and these findings are in agreement with many earlier reports [9,10,11,39,40,54,63,64] but disagree with the findings of George and Ewelike-Ezeani [34]. In some cases of acute malaria, however, lymphocytopenia has been reported, but this has been associated with redistribution of lymphocytes with sequestration in the spleen [65,66].…”

Section: Discussionsupporting

confidence: 86%

Hematological Profile of Children With Malaria in Sorong, West Papua, Indonesia

Jiero

Pasaribu

2020

Preprint

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Background: Malaria remains a major public health problem in Indonesian Papua, with children under five years of age being the most affected group. Hematological changes such as cytopenia that occur during malaria infection have been suggested as potential predictors and can aid in the diagnosis of malaria. This study aimed to assess the hematological alterations associated with malaria infection in children presenting with signs and symptoms of malaria. Methods: A retrospective study was performed by collecting data from the medical records of malaria patients at Sorong Regional General Hospital, Sorong, West Papua, Indonesia, both from outpatient and inpatient clinics, from January 2014 until December 2017. The laboratory profile of children suffering from malaria was evaluated. Results: One hundred and eighty-two children aged 1 month to 18 years old were enrolled. The subjects were mostly male (112, 61.5%) with a mean age of 6.45 years (SD = 4.3 years). Children <5 years suffering from malaria had the highest number at 77 (42.3%). One hundred two subjects (56%) were infected with Plasmodium falciparum. Half of the enrolled subjects (50%) had hemoglobin level (Hb) between 5.1 and 10 gr/dL. A total of 41 children (53.2%) less than 5 years old suffered from P. falciparum infection. In the age group of 5-10 years, there were 34 children (57.6%) who suffered from P. falciparum, and in the age group >10 years, 27 children (58.7%) suffered from P. falciparum infection. Only 4 subjects (5.2%) in the less than 5 years old age group had mixed malaria infection. Of the eight parameters of the hematological profile, there were five parameters that were significantly associated with the diagnostic criteria, namely hemoglobin, hematocrit, leukocytes, platelets and monocytes (p <0.05). Generally, clinical symptoms are not significantly associated with a malaria diagnosis, and only one variable showed a significant relationship, pale, with a p value of 0.001. Conclusions: Children with malaria had changes in some hematological parameters, with anemia, low platelet count, white blood count, and lymphocyte count being the most important predictors of malaria infection in our study area. These parameters could improve malaria diagnosis when used in combination with other clinical diagnoses and microscopy.

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Section: Discussionsupporting

confidence: 86%

Hematological Profile of Children With Malaria in Sorong, West Papua, Indonesia

Jiero

Pasaribu

2020

Preprint

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“…The different values may be associated with environmental factors, socioeconomic status, or malaria immunity, among other factors (12)(13)(14). The study has further revealed that there were no statistically significant differences in granulocyte and lymphocyte counts between malaria-infected and noninfected children, and these findings are in agreement with many earlier reports (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) but disagree with the findings of George and Ewelike-Ezeani (17). In some cases of acute malaria, however, lymphopenia has been reported, but this has been associated with redistribution of lymphocytes with sequestration in the spleen (26,27).…”

Section: Discussionsupporting

confidence: 82%

“…This finding may likely give a clue in the diagnosis of malaria, especially in an endemic area. The high prevalence of thrombocytopenia in this study has been confirmed by earlier reports (11,17,25).…”

Section: Discussionsupporting

confidence: 80%

Haematological changes in malaria-infected children in North-West Nigeria

Momodu¹,

Shehu²,

Ihesiulor³

et al. 2013

Turk J Med Sci

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Neodymium-titania/silica films were prepared by the sol-gel method with the addition of various amounts of hydroxy propyl cellulose (HPC) and 5.09 × 10 −5 g g −1 solution of carboxy methyl cellulose (CMC) in saturated conditions. The porous Nd-TiO 2 /SiO 2 was obtained after heat treatment for 2 h at 500 • C, with the surface area up to 276 m 2 g −1 , which was measured using the Brunauer, Emmett, and Teller (BET) method. Scanning electron microscopy (SEM) showed that the particle size of Nd-TiO 2 /SiO 2 decreased and the microstructure of the film became loose in suitable conditions with the addition of CMC to HPC. Subsequently, the photocatalytic activity of Nd-TiO 2 /SiO 2 film under visible light irradiation was achieved to an optimum when the concentrations became 3.825 × 10 −3 and 5.09 × 10 −5 g g −1 sol. for HPC and CMC, respectively.

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“…The haemoglobin concentration for the treated groups showed a significant (P<0.05) increase relative to the negative control; the WBC count for the treated groups showed an increase when compared to the negative control; the levels of eosinophils and basophils were elevated in the treated groups whereas the Neutrophil level was significantly (p<0.05) lowered relative to the negative control. The decreased WBC count in the infected, untreated group has been attributed to the damaging effect of the parasite in hematopoietic stem cells and hence the progression of the disease [55], this is because white cells are first line of defence in the incidence of infection [56]. The extract increased WBC count suggestive of the ability of the extract to increase the production of the cells of the immune system, thereby increasing the ability of the mice to combat the infection.…”

Section: Resultsmentioning

confidence: 99%

Antimalarial Activity of Ethanolic Leaf Extract of Maesobotrya barteri and Effects on Some Hematological and Biochemical Parameters of Mice

Peters

Ezendiokwere

Njoku

et al. 2017

JALSI

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Aim: This study was conducted to determine the antimalarial activity of ethanolic leaf extract of Maesobotrya barteri, and effects on some hematological and biochemical parameters. Methodology: Twenty eight albino mice were selected and twenty four of these were injected intraperitoneally with 1×10 6 Plasmodium berghei (NK65 strain) parasitized red blood cells in 0.5 ml of distilled water on the first day. After 72 hours, the animals were placed in seven groups having four animals each. Group 1 was uninoculated and untreated. Group 2 (inoculated and untreated) served as negative control. Group 3 was treated with 25 mg/kg bwt chloroquine and served as the positive control. Group 4 was treated with 4 mg/kg body weight of artesunate. 500 mg/kg, 800 mg/kg and 1000 mg/kg body weight of the extract were administered to groups 5, 6 and 7 respectively for four (4) days. On the fifth day post administration, the animals were anesthesized and blood obtained by cardiac puncture for hematological and biochemical investigation. The liver from the mice were harvested after sacrifice on the fifth day and subjected to histological Original Research Article

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Effects of Falciparum Malaria Infection on Some Hematological Indices and Renal functions

Cited by 6 publications

References 0 publications

Hematological Profile of Children With Malaria in Sorong, West Papua, Indonesia

Hematological Profile of Children With Malaria in Sorong, West Papua, Indonesia

Haematological changes in malaria-infected children in North-West Nigeria

Antimalarial Activity of Ethanolic Leaf Extract of Maesobotrya barteri and Effects on Some Hematological and Biochemical Parameters of Mice

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