Effects of F- on apatite-octacalcium phosphate intergrowth and crystal morphology in a model system of tooth enamel formation

Iijima, Mayumi; Tohda, Hisako; Suzuki, Hiroshi; Yanagisawa, Takaaki; Moriwaki, Yuji

doi:10.1007/bf00301634

Cited by 81 publications

(46 citation statements)

References 22 publications

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“…Fluoride can accelerate epitaxial growth of apatite crystals on the OCP precursor, changing the crystal morphology [Moriwaki et al, 1983;Iijima et al, 1992]. Changes in the morphology of apatite crystals grown from unstable supersaturated solution as the result of fluoride addition have also been reported previously by Eanes and Meyer [1977], who reported that the presence of fluoride eliminated the formation of the intermediate OCP phase.…”

Section: Discussionmentioning

confidence: 65%

Effect of Fluoride on the Morphology of Calcium Phosphate Crystals Grown on Acid-Etched Human Enamel

2009

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The aim of this study was to examine the effect of fluoride ion concentration on the morphology of calcium phosphate crystals grown on acid-etched enamel as a model for tooth enamel erosion. Samples were immersed in calcification solution for 16 h and changes in crystal morphology were monitored by field emission scanning electron microscopy. Without fluoride, plate-like octacalcium phosphate crystals (20 nm thick, 2–10 μm wide) were formed. With 1–10 mg/l fluoride, arrays of denser needle-like nanocrystals (20–30 nm wide, >500 nm in length) were formed. We conclude that there is a minimal fluoride concentration (1 mg/l) that dramatically affects the morphology of calcium phosphate crystals grown on etched enamel in vitro.

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Section: Discussionmentioning

confidence: 65%

Effect of Fluoride on the Morphology of Calcium Phosphate Crystals Grown on Acid-Etched Human Enamel

2009

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“…[21][22][23][24] The presence of OCP between HA layers was also detected by HREM in in vitro prepared calcium phosphate phases. [25][26][27] The thickness of these lines would then correspond to the water layer of OCP (0.8 nm). We found variable thicknesses of approximately 1 nm.…”

Section: +mentioning

confidence: 99%

High-resolution electron microscopy study of synthetic carbonate and aluminum containing apatites

Layani

Cuisinier

Steuer

et al. 2000

J. Biomed. Mater. Res.

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Aluminum (Al)-containing calcium-deficient carbonated hydroxyapatites were produced by a precipitation method from aqueous solution with carbonate (0-6.1%) and aluminum (0.1-0.5%) concentrations close to those found in biological materials. Two series of apatites were prepared: one at pH 7.0 and another at pH 9. 0. High-resolution electron microscopy has shown that many of them possess structural defects such as screw dislocations, grain boundaries, and central defects. Samples with high carbonate content and high water and high Al(3+) content had a high amount of structural defects. Accordingly, a sample (7Al1) with a relatively high carbonate content (6.1%) and a sample (7Al6) without carbonate but with a relatively high water (2.0 mol) and Al(3+) content (0. 39%) presented the highest amount of structural defects, 54% and 47%, respectively. A sample (7Al13) with a low level of crystalline water (1 mol) and low carbonate (2.5%) showed a small amount of defects. The presence of water associated with Al(3+) induced a high number of crystals having a central defect with a great similarity to the so-called water layer of octacalcium phosphate (OCP). Observed images of all these crystals have shown good correspondence with the computer-simulated image based on the crystal structure of hydroxyapatite, indicating that the addition of Al(3+) and carbonate does not perturb the apatitic structure.

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“…This may be due to fluoride-induced conversion of acidic precursors such as amorphous calcium phosphate or octacalcium phosphate to apatite [Iijima et al, 1992]. Perhaps a more likely explanation would be the higher relative supersaturation of tissue fluids with respect to a precipitating fluoridated mineral phase.…”

Section: Crystal Growthmentioning

confidence: 99%

“…These range from amorphous short range order calcium phosphates [Posner, 1985] through brushite-like phases to octacalcium phosphate [Brown et al, 1987;Iijima et al, 1992;Johnsson and Nancollas, 1992]. These are often said to be stabilised by carbonate or magnesium.…”

Section: Initiation Of Precipitation During Secretionmentioning

confidence: 99%

The Effect of Fluoride on the Developing Tooth

et al. 2004

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This review aims to outline the effects of fluoride on the biological processes involved in the formation of tooth tissues, particularly dental enamel. Attention has been focused on mechanisms which, if compromised, could give rise to dental fluorosis. The literature is extensive and often confusing but a much clearer picture is emerging based on recent more detailed knowledge of odontogenesis. Opacity, characteristic of fluorotic enamel, results from incomplete apatite crystal growth. How this occurs is suggested by other changes brought about by fluoride. Matrix proteins, associated with the mineral phase, normally degraded and removed to permit final crystal growth, are to some extent retained in fluorotic tissue. Fluoride and magnesium concentrations increase while carbonate is reduced. Crystal surface morphology at the nano-scale is altered and functional ameloblast morphology at the maturation stage also changes. Fluoride incorporation into enamel apatite produces more stable crystals. Local supersaturation levels with regard to the fluoridated mineral will also be elevated facilitating crystal growth. Such changes in crystal chemistry and morphology, involving stronger ionic and hydrogen bonds, also lead to greater binding of modulating matrix proteins and proteolytic enzymes. This results in reduced degradation and enhanced retention of protein components in mature tissue. This is most likely responsible for porous fluorotic tissue, since matrix protein removal is necessary for unimpaired crystal growth. To resolve the outstanding problems of the role of cell changes and the precise reasons for protein retention more detailed studies will be required of alterations to cell function, effect on specific protein species and the nano-chemistry of the apatite crystal surfaces.

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Effects of F- on apatite-octacalcium phosphate intergrowth and crystal morphology in a model system of tooth enamel formation

Cited by 81 publications

References 22 publications

Effect of Fluoride on the Morphology of Calcium Phosphate Crystals Grown on Acid-Etched Human Enamel

Effect of Fluoride on the Morphology of Calcium Phosphate Crystals Grown on Acid-Etched Human Enamel

High-resolution electron microscopy study of synthetic carbonate and aluminum containing apatites

The Effect of Fluoride on the Developing Tooth

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