Effects of extremely low frequency magnetic field on the antioxidant defense system in mouse brain: a chemiluminescence study

Lee, Byung-Cheon; Johng, Hyeon-Min; Lim, Jin Ho; Jeong, Ji Hoon; Baik, Ku Youn; Nam, Tae Jeong; Lee, Jung Ho; Kim, Jungdae; Sohn, Uy Dong; Yoon, Gilwon; Shin, Sanghoon; Soh, Kwang–Sup

doi:10.1016/j.jphotobiol.2003.10.003

Cited by 78 publications

(49 citation statements)

References 24 publications

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“…Results obtained in the present investigation supports the earlier observations, which had reported the occurrence of oxidative/nitrosative stress in response to the MF exposure (Li and Chow 2000;Noda et al 2000;Kabuto et al 2001;Lee et al 2004), including effects on cell signaling processes (Liboff et al 2003;Zhang et al 2010) and carcinogenic effects (Bayazit et al 2010). Previous studies suggest that static and time-varying electric and MFs exposure caused oxidative DNA damage (Ivancsits et al 2003;Yokus et al 2005), increased plasma, liver, lung and kidney TBARS and SOD levels (Harakawa et al 2005;Guler (Jelenkovic et al 2005;Di Loreto et al 2009) altered cell proliferation , cortical serotonergic neurotransmission (Janac et al 2009) and memory impair (Jadidi et al 2007) in various biological organisms.…”

Section: Discussionsupporting

confidence: 92%

“…Since melatonin is an antioxidant and its decrease is concomitant with accumulation of free radicals (PandiPerumal et al 2013), oxidative stress increases when exposed to EMF, hence supplementation of antioxidants were recommended under these conditions (Zwirska-Korczala et al 2004;Sokolovic et al 2008;El-Helaly and Abu-Hashem 2010;Kerman and Senol 2012). Interestingly, the EMF was not only reported to increase the life span of free radicals (Kabuto et al 2001;Stevens 2004), but was also involved in weakening the antioxidant defense mechanism (Lee et al 2004;Falone et al 2008), leading to increased oxidative stress condition (Blank and Goodman 2009;Martinez-Samano et al 2012). Several earlier studies have suggested that short and long-term exposure to 40-60 Hz ELF magnetic fields (MF) induce oxidative stress on various regions of the rodent's brain such as, cerebellum, hippocampus and striatum (Fu.…”

Section: Introductionmentioning

confidence: 99%

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Extremely low frequency magnetic fields induce oxidative stress in rat brain

Pk¹,

Rajendra²,

Devendranath³

et al. 2014

gpb

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Abstract. The present investigation was conducted to understand the influence of long-term exposure of rats to extremely low frequency magnetic fields (ELF-MF), focusing on oxidative stress (OS) on different regions of rat's brain. Male Wistar rats (21-day-old) were exposed to ELF-MF (50 Hz; 50 and 100 µT) for 90 days continuously; hippocampal, cerebellar and cortical regions from rats were analyzed for (i) reactive oxygen species (ROS), (ii) metabolites indicative of OS and (iii) antioxidant enzymes. In comparison to control group rats, the rats that were continuously exposed to ELF-MF caused OS and altered glutathione (GSH/GSSG) levels in dose-dependent manner in all the regions of the brain. Accumulation of ROS, lipid peroxidation end products and activity of superoxide dismutase in different regions was in the descending order of cerebellum > hippocampus > cortex. Decrement in GSH/GSSG levels and increment in glutathione peroxidase activity were in the descending order of hippocampus > cerebellum > cortex. The continuous exposure to ELF-MF caused OS in all the examined regions of brain more significantly at 100 µT than at 50 µT. Varied influences observed in different regions of the brain, as documented in this study, may contribute to altered metabolic patterns in its related regions of the central nervous system, leading to aberrant neuronal functions.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Extremely low frequency magnetic fields induce oxidative stress in rat brain

Pk¹,

Rajendra²,

Devendranath³

et al. 2014

gpb

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show abstract

“…It should be mentioned that "in vivo" experiments in literature also seem to confirm that chronic exposure to ELF-EMF is able to generate a stress oxidative status [32][33][34]. The "in vitro" experiments reported here, as well as the results derived from "in vivo" techniques [13,22,24,25,28,35,36] in mice, show that the presence of ELF-EMF can induce a variable and specie-specific alteration of the stress oxidative pathway.…”

Section: Discussionsupporting

confidence: 79%

ELF-EMFs INDUCED EFFECTS ON CELL LINES: CONTROLLING ELF GENERATION IN LABORATORY

Farina

Mariggiò³

et al. 2010

PIER B

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Abstract-The aim of this paper is to discuss the effects of the exposure to Extremely Low Frequency ElectroMagnetic Fields (ELFEMFs) on non-and excitable cells using in vitro cell models, namely neuron-like cell line (PC12), glioblastoma-derived GL15 cells as glial model and C2C12 myocytes as muscle model, focusing our attention on standardized protocols for ELF-EMFs generation and exposure. A major issue in laboratory -and likely in nature -studies about possible biological effects of ELF waves is the difficulty in providing standard, reproducible environmental conditions. Hence, as part of the work we have developed an exposure system including a probing scanner, able to sample a given volume and to measure the timevarying magnetic field vector. The system allows detection, monitoring and removal of electromagnetic noise sources, as well as means to assess field homogeneity in terms of intensity and polarization.

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“…ELF EMF exposure may be harmful by impairing the antioxidant defenses (19). Results indicated that extremely low magnetic field of 60 Hz could adversely affect body antioxidant defensive system by ROS production , other than superoxide radicals (20).…”

Section: Resultsmentioning

confidence: 99%

“…Based on conducted studies oxidative stress could induce female pathogenesis leading to female fertility and subfertility. ROS could affect physiological functions of female reproduction system tracts and has been implicated in ovarian follicles apoptosis under influence of external chemical and physical factors (20,28,29). Based on results, Allium cepa and cinnamon could moderate adverse effects of exposure to electromagnetic field on LH and FSH and estrogen level.…”

Section: CMmentioning

confidence: 98%