Effects of Extracts of Coriolus versicolor (I'm-Yunity^™) on Cell-Cycle Progression and Expression of Interleukins-1β,-6, and -8 in Promyelocytic HL-60 Leukemic Cells and Mitogenically Stimulated and Nonstimulated Human Lymphocytes

Abstract

I'm-Yunity acts selectively in HL-60 leukemic cells, resulting in cell cycle restriction through the G(1)/S checkpoint and the induction of apoptosis.

Effect of Coriolus versicolor supplemented diet on innate immune response and disease resistance in kelp grouper Epinephelus bruneus against Listonella anguillarum

“…com); it exhibits anti-cancer activity both in vitro [21] and in vivo [22]. Polysaccharopeptides (PSPs), a protein-bound polysaccharide isolated from C. versicolor, is considered as a strong potential candidate for drug development in treatment and prevention of human cancers [23,24], suppression on DNA and RNA synthesis [25], and enhance immune functions [23,24]. Therefore, the present study was performed to investigate the effect of C. versicolor supplemented diets on innate immune response and disease resistance in kelp grouper Epinephelus bruneus against Listonella anguillarum.…”

Differential regulation of proliferation, cell cycle control and gene expression in cultured human aortic and pulmonary artery endothelial cells by resveratrol

“…Following an overnight incubation, cells were exposed to increasing concentrations of resveratrol as specified in the text. Cell numbers were determined at the indicated times by trypan blue exclusion, as previously described (32)(33)(34).…”

“…HAECs and HPAECs were treated with resveratrol (0, 1, 10, and 100 μM) for 24 or 48 h, and cell cycle phase distribution was assayed by flow cytometry as described (33,35,36). The cellular DNA content was obtained and the percentage of cells in the respective phases (G 1 , S and G 2 /M) of the cell cycle was quantified.…”

Uptake of resveratrol and role of resveratrol-targeting protein, quinone reductase 2, in normally cultured human prostate cells

“…After an overnight incubation, cells were treated with increasing doses of resveratrol, as specified in the text. Cell numbers were determined at the indicated times by trypan blue exclusion, as previously described [21][22][23].…”

“…Prostate stromal cells were treated with different concentrations of resveratrol (0, 10 and 50 µmol L -1 ) for 2, 4 and 6 days, and cell cycle phase distribution was assayed by flow cytometry as described [22,24,25]. The cellular DNA content was obtained and the percentage of cells in the respective phases (G1, S and G2/M) of the cell cycle was quantified.…”