Effects of external low intensity focused ultrasound on inflammatory markers in neuropathic pain

Hellman, Abigail; Clum, Alicia; Maietta, Teresa; Srikanthan, Adithya; Patel, Vraj; Panse, Drishti; Zimmerman, Olivia; Neubauer, Paul; Nalwalk, Julia W.; Williams, Emery; Ghoshal, Goutam; Burdette, Clif; Pilitsis, Julie G.

doi:10.1016/j.neulet.2021.135977

Cited by 5 publications

(5 citation statements)

References 44 publications

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“…However, prolonged exposure to high levels of these proteins can result in neuronal damage and disease progression ( Deng et al, 2010 ; Turner et al, 2014 ). Male rats with common peroneal nerve injury, a model of neuropathic pain, treated with FUS at an acoustic intensity of 8 W, were found to have a decreased protein expression of interleukin (IL)-6, IL-1β and tumor necrosis factor (TNF)-α, pro-inflammatory cytokines produced by immune cells which are involved in acute-phase inflammatory responses against infections and tissue damage ( Hellman et al, 2021 ). Of note, IL-6, IL-1β and TNF-α can be released by microglia, and their elevated levels are associated with the onset of neuropathic pain ( Zhao et al, 2017 ).…”

Section: Effect Of Fus and Fus + Microbubbles: The Immune Hypothesismentioning

confidence: 99%

“…Of note, IL-6, IL-1β and TNF-α can be released by microglia, and their elevated levels are associated with the onset of neuropathic pain ( Zhao et al, 2017 ). FUS treatment alone can also modulate microglial cytokine production in mice and alleviate allodynia, a type of neuropathic pain, thereby providing a promising intervention to mitigate some of the symptoms associated with inflammation ( Hellman et al, 2021 ). Similar outcomes were also reported in the substantia nigra of male rats challenged with 6-hydroxydopamine (6-OHDA), which models Parkinson’s disease pathology ( Sung et al, 2022 ).…”

Section: Effect Of Fus and Fus + Microbubbles: The Immune Hypothesismentioning

confidence: 99%

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Using focused ultrasound to modulate microglial structure and function

Grewal,

Gonçalves de Andrade,

Kofoed

et al. 2023

Front. Cell. Neurosci.

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Transcranial focused ultrasound (FUS) has the unique ability to target regions of the brain with high spatial precision, in a minimally invasive manner. Neuromodulation studies have shown that FUS can excite or inhibit neuronal activity, demonstrating its tremendous potential to improve the outcome of neurological diseases. Recent evidence has also shed light on the emerging promise that FUS has, with and without the use of intravenously injected microbubbles, in modulating the blood-brain barrier and the immune cells of the brain. As the resident immune cells of the central nervous system, microglia are at the forefront of the brain’s maintenance and immune defense. Notably, microglia are highly dynamic and continuously survey the brain parenchyma by extending and retracting their processes. This surveillance activity aids microglia in performing key physiological functions required for brain activity and plasticity. In response to stressors, microglia rapidly alter their cellular and molecular profile to help facilitate a return to homeostasis. While the underlying mechanisms by which both FUS and FUS + microbubbles modify microglial structure and function remain largely unknown, several studies in adult mice have reported changes in the expression of the microglia/macrophage marker ionized calcium binding adaptor molecule 1, and in their phagocytosis, notably of protein aggregates, such as amyloid beta. In this review, we discuss the demonstrated and putative biological effects of FUS and FUS + microbubbles in modulating microglial activities, with an emphasis on the key cellular and molecular changes observed in vitro and in vivo across models of brain health and disease. Understanding how this innovative technology can modulate microglia paves the way for future therapeutic strategies aimed to promote beneficial physiological microglial roles, and prevent or treat maladaptive responses.

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Section: Effect Of Fus and Fus + Microbubbles: The Immune Hypothesismentioning

confidence: 99%

Section: Effect Of Fus and Fus + Microbubbles: The Immune Hypothesismentioning

confidence: 99%

Using focused ultrasound to modulate microglial structure and function

Grewal,

Gonçalves de Andrade,

Kofoed

et al. 2023

Front. Cell. Neurosci.

View full text Add to dashboard Cite

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“…They also demonstrated that ultrasound can alter pain behavior and allodynia in a porcine peroneal nerve-injury model [ 141 ]. This may be related to the improvement in the inflammatory response of the dorsal root ganglia via ultrasound stimulation [ 142 ]. In addition to acting on the peripheral nerves, ultrasound can also modulate the central brain nuclei to treat pain.…”

Section: Ultrasound Brain Modulation and Possible Writingmentioning

confidence: 99%

The Emergence of Functional Ultrasound for Noninvasive Brain–Computer Interface

et al. 2023

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A noninvasive brain–computer interface is a central task in the comprehensive analysis and understanding of the brain and is an important challenge in international brain-science research. Current implanted brain–computer interfaces are cranial and invasive, which considerably limits their applications. The development of new noninvasive reading and writing technologies will advance substantial innovations and breakthroughs in the field of brain–computer interfaces. Here, we review the theory and development of the ultrasound brain functional imaging and its applications. Furthermore, we introduce latest advancements in ultrasound brain modulation and its applications in rodents, primates, and human; its mechanism and closed-loop ultrasound neuromodulation based on electroencephalograph are also presented. Finally, high-frequency acoustic noninvasive brain–computer interface is prospected based on ultrasound super-resolution imaging and acoustic tweezers.

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“…A global open registry of thalamotomy procedures has also been generated (NCT03100474). An interest exists in neuromodulatory, reversible low-intensity, low-frequency ultrasound applied to CNP treatments, but these efforts also remain in the early research stage [ 50 , 51 , 52 ].…”

Section: Surgical Treatments For Central Painmentioning

confidence: 99%

Review of the Treatments for Central Neuropathic Pain

et al. 2022

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Central neuropathic pain (CNP) affects millions worldwide, with an estimated prevalence of around 10% globally. Although there are a wide variety of treatment options available, due to the complex and multidimensional nature in which CNP arises and presents symptomatically, many patients still experience painful symptoms. Pharmaceutical, surgical, non-invasive, cognitive and combination treatment options offer a generalized starting point for alleviating symptoms; however, a more customized approach may provide greater benefit. Here, we comment on the current treatment options that exist for CNP and further suggest the need for additional research regarding the use of biomarkers to help individualize treatment options for patients.

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Effects of external low intensity focused ultrasound on inflammatory markers in neuropathic pain

Cited by 5 publications

References 44 publications

Using focused ultrasound to modulate microglial structure and function

Using focused ultrasound to modulate microglial structure and function

The Emergence of Functional Ultrasound for Noninvasive Brain–Computer Interface

Review of the Treatments for Central Neuropathic Pain

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