Effects of exposure to pyrethroid cyfluthrin on serotonin and dopamine levels in brain regions of male rats

Rodríguez, José‐Luis; Arés, Irma; Castellano, V.; Martínez-Larrañaga, María-Rosa; Anadón, Arturo; Martínez, Marta

doi:10.1016/j.envres.2016.01.023

Cited by 37 publications

(10 citation statements)

References 58 publications

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“…Yet, if one or both of the two conversion steps were affected needs to be further explored. The effects of CHL and CYF on 5-HT were also reported in some other researches, Rodriguez et al (2016) reported that CYF dosedependently reduced 5-HT levels in multiple rat brain regions (hypothalamus, striatum, midbrain, hippocampus, and prefrontal cortex) while Tufi et al (2016) found that exposure to CHL enhanced phenylalanine and tryptophan concentrations in larval zebrafish. Previous studies have shown that reduced 5-HT levels affect the swimming behavior of larval zebrafish, including a reduction in swimming speed (Airhart et al, 2012;Tian et al, 2021).…”

Section: Effects Of Chlorpyrifos and Cyfluthrin On Neurotransmitter L...supporting

confidence: 74%

Combined effects of chlorpyrifos and cyfluthrin on neurobehavior and neurotransmitter levels in larval zebrafish

Zhang

Fan

Luo

et al. 2022

J of Applied Toxicology

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Chlorpyrifos and cyfluthrin are insecticides commonly used in agriculture. The mixed residues of chlorpyrifos and cyfluthrin in the aquatic environment may have combined effects on nontarget species. Therefore, studying the combined toxic effects and mechanisms of pesticide mixtures is of great significance to environmental risk assessment. To evaluate the risk of combined exposure, we examined the effects of both compounds, separately and together, on motor activity, acetylcholinesterase (AChE) activity, and neurotransmitter levels in larval zebrafish. Chlorpyrifos exposure significantly reduced functional motor capacity (swim distance and velocity) and enhanced meandering, while cyfluthrin exposure alone had no significant effects on swim parameters. However, combined exposure significantly reduced total swimming distance and mean velocity and increased meandering. Both compounds alone and the combination significantly reduced AChE activity, and the combined effect was antagonistic. Combined exposure also significantly altered the concentrations of serotonin, serotonin precursors, and dopamine precursors, as well as concentrations of the amino acid neurotransmitters glycine, alanine, and aspartic acid. Combined exposure to chlorpyrifos and cyfluthrin exhibited distinct joint action modes in terms of neurobehavior, AChE activity, and neurotransmitter levels, thereby providing an experimental basis for assessing the combined exposure to chlorpyrifos and cyfluthrin's environmental risk.

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Section: Effects Of Chlorpyrifos and Cyfluthrin On Neurotransmitter L...supporting

confidence: 74%

Combined effects of chlorpyrifos and cyfluthrin on neurobehavior and neurotransmitter levels in larval zebrafish

Zhang

Fan

Luo

et al. 2022

J of Applied Toxicology

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“…On the basis of the present results, it might be hypothesized that the significant (P<0.05) lower in dopamine (DA) content (Table 2), could be due to either inhibition of biosynthesis of DA, or decrease in tyrosine hydroxylase (TH) and/or decrease in aromatic L-amino-acid decarboxylase synthesis as observed after exposure to the pyrethroid deltamethrin 4,32 . Thus, β-cyf toxicity might also be due to the release of unstable cyanohydrins.…”

Section: Resultsmentioning

confidence: 99%

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2017

IJPSR

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ABSTRACT:The present study was designed to evaluate the protective effect of omega-3 against β-cyfluthrin (β-cyf)-induced neurotransmitters' impairment, oxidative damage, testicular toxicity and genotoxicity. Adult male Wistar rats were divided equally into four groups: Group (I): Control, Group (II): β-cyf (5 mg/kg body weight/day), Group (III): omega-3 (400 mg/kg body weight/da y) + β-cyf (5 mg/kg body weight/day), Group (IV): omega-3 (400 mg/kg body weight/day). β-cyf's treatment for 8 weeks inhibited the activities of AChE, DA, LDH, total ATPase and Na + /K + ATPase. Also, β-cyf resulted in an increase in oxidative stress as indicated by elevations in the levels of MDA and NO while, the levels of TAC, thiol content and TP were decreased in brain and testis. Sperm count, sperm motility and testosterone levels were reduced while, sperm abnormalities, FSH and LH levels were increased in β-cyf-treated group. Also, β-cyf administration led to a significant increase in TNFα, IL-6 and APP mRNA expressions. In addition, β-cyf caused histopathological alterations in brain and testis. The present results showed that omega-3 could improve all the measured parameters. In conclusion, omega-3 could exhibit protective effects against β-cyf induced neurological and testicular damage.

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“…Because of their lipophilicity, pyrethroids can cross the blood-brain barrier and reach the central nervous system at potentially neurotoxic concentrations. They disrupt the function of the nervous system by their effect on the voltagesensitive sodium channels (VSSC) as well as the release of neurotransmitters (Rodriguez et al 2016).…”

Section: Results and Discussion:-mentioning

confidence: 99%

Gc-MS Based Metabolic Profile of Brain Tissue in Common Carp Following Acute Exposure to Cypermethrin.

AliHabotta¹

2019

IJAR

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Effects of exposure to pyrethroid cyfluthrin on serotonin and dopamine levels in brain regions of male rats

Cited by 37 publications

References 58 publications

Combined effects of chlorpyrifos and cyfluthrin on neurobehavior and neurotransmitter levels in larval zebrafish

Combined effects of chlorpyrifos and cyfluthrin on neurobehavior and neurotransmitter levels in larval zebrafish

Untitled

Gc-MS Based Metabolic Profile of Brain Tissue in Common Carp Following Acute Exposure to Cypermethrin.

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