Effects of exposure to phthalate during early pregnancy on gestational diabetes mellitus: a nested case–control study with propensity score matching

Chen, Wei; He, Caidie; Liu, Xiang; An, Senyou; Wang, Xia; Tao, Lin; Zhang, Haonan; Tian, Yingkuan; Wu, Nian; Xu, Pei; Liao, Dengqing; Liao, Juan; Wang, Linglu; Fang, Derong; Xiong, Shimin; Liu, Yijun; Tian, Kunming; Li, Quan; Huang, Jingyi; Yuan, Hongyu; Chen, Xiaoshan; Zhang, Li; Shen, Xubo; Zhou, Yuanzhong

doi:10.1007/s11356-022-24454-y

Cited by 7 publications

(5 citation statements)

References 67 publications

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“…The concentration of the five metabolites Σ 5 DEHP ranged from 8.72 to 3524.02 ng mL −1 , with the median of 125.67 ng mL −1 . MEHHP had the highest concentration among the DEHP metabolites in this study and its concentration was higher than that in rural residents from Zunyi in Southwest China (median: 7.84 ng mL −1 ), 47 Hunan in Southern China (median: 32.55 ng mL −1 ) 33 and rural population in Egypt (median: 23.00 ng mL −1 ). 48 In addition, the exposure levels of DEHP in different gender groups and age groups of our study were also higher compared with those in other regions.…”

Section: Urinary Concentrations Of Pae Metabolitesmentioning

confidence: 49%

Current Phthalate Exposure Risks of Rural Population in the Northwest China: Evidence from an Internal Exposure Study

Zheng,

Hua,

Zhang

et al. 2024

Environ. Health

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Phthalates (PAEs) are synthetic chemicals widely used in industrial and personal consumer products as adhesives or plasticizers. PAEs have been demonstrated to have toxic effects on the human body. However, biological monitoring data for the internal PAE exposure levels of Chinese rural residents are still limited. The present study investigated the exposure levels of ten phthalate metabolites (mPAEs) of rural residents in Northwest China. The results showed that mPAEs were wildly prevalent in urine and the geometric mean concentration of Σ10mPAEs was 957.02 ng mL–1 (adjusted by specific gravity). Mono-n-butyl phthalate (MBP) and metabolites of di(2-ethylhexyl)-phthalate (DEHP) were the most dominant mPAEs in urine, with specific gravity adjusted median concentrations of 174.67 and 156.30 ng mL–1, respectively. Urinary concentrations of mPAEs were significantly associated with age, body mass index and economic level (p < 0.05). By calculating the percentage and relative conversion rate of DEHP metabolites, it was found that the degree of oxidative metabolism of DEHP in children was significantly higher than that in adults (p < 0.05), indicating that the pathway and degree of DEHP oxidation were age-related. The risk assessment showed that 59.12% of rural residents may have a noncancer risk from PAE exposure. This study provides important basis for assessing the occurrence and exposure of urinary phthalate metabolites among rural residents in China.

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Section: Urinary Concentrations Of Pae Metabolitesmentioning

confidence: 49%

Current Phthalate Exposure Risks of Rural Population in the Northwest China: Evidence from an Internal Exposure Study

Zheng,

Hua,

Zhang

et al. 2024

Environ. Health

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“…Phthalate has been widely regarded as an environmental risk factor to human health. A large number of clinical studies have revealed that phthalate exposure was closely related to various diseases, including asthma [ 41 ], depression [ 42 ], diabetes [ 43 ] and infant allergic rhinitis [ 44 ]. In the past decade, scientific research has investigated whether there is an association between urinary phthalates and their metabolites and cancer, and people have tried to identify some main phthalate metabolites in urine of cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Association between urinary phthalates and phthalate metabolites and cancer risk: A systematic review and meta-analysis

Meng,

Yang,

Song

et al. 2024

Heliyon

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“…MEOHP, for instance, has been linked to negative impacts on intelligence quotient and attention in children, 16 and pregnant women exposed to it may face an elevated risk of gestational diabetes. 17 Moreover, a positive correlation has been found between MECPP and the breast cancer risk for women, 18 and exposure of the fetus to MEOHP or ∑DEHP has been linked to an elevated risk of intrauterine growth retardation. 19 Additionally, both MEHHP and MECPP have been shown to increase the secretion of β-hexosaminidase by mast cells, leading to skin rashes.…”

Section: Discussionmentioning

confidence: 99%

Relationship between the use of plastics in refrigerator food storage and urine phthalate metabolites: the Korean National Environmental Health Survey (KoNEHS) cycle 3

Kang,

Cho,

Yoon

2023

Ann Occup Environ Med

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Background Plastics are high-molecular-weight materials composed of long carbon chains. They are prevalent in daily life, present in various items such as food containers and microwavable packaging. Phthalates, an additive used to enhance their flexibility, are endocrine-disrupting chemicals. We utilized the data from the Korean National Environmental Health Survey (KoNEHS) cycle 3, representing the general South Korean population, to investigate the relationship between the use of plastics in refrigerator food storage and phthalate exposure. Methods We assessed 3,333 adult participants (aged ≥ 19 years) including 1,526 men and 1,807 women, using data from KoNEHS cycle 3. Using the 75th percentile concentration, urine phthalate metabolites were categorized into high and low-concentration groups. χ 2 test was conducted to analyze variations in the distribution of each variable, considering sociodemographic factors, health-related factors, food intake, the use of plastics, and the concentration of urine phthalate metabolites as the variables. To calculate odds ratios (ORs) for the high-concentration group of urine phthalate metabolites based on the use of plastics in refrigerator food storage, logistic regression analysis was conducted. Results In men, the use of plastics in refrigerator food storage had significantly higher adjusted ORs compared to those using the others. The adjusted ORs were calculated as follows: mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) had an OR of 1.35 (95% confidence interval [CI]: 1.05–1.72), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) had an OR of 1.48 (95% CI: 1.16–1.88), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP) had an OR of 1.32 (95% CI: 1.04–1.66), ∑di(2-ethylhexyl) phthalate (∑DEHP) had an OR of 1.37 (95% CI: 1.08–1.74) and mono-n-butyl phthalate (MnBP) had an OR of 1.44 (95% CI: 1.13–1.84). Conclusion The concentrations of urine phthalate metabolites (MEHHP, MEOHP, MECPP, ∑DEHP, and MnBP) were significantly higher in men who used plastics in refrigerator food storage compared to those using the others.

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Effects of exposure to phthalate during early pregnancy on gestational diabetes mellitus: a nested case–control study with propensity score matching

Cited by 7 publications

References 67 publications

Current Phthalate Exposure Risks of Rural Population in the Northwest China: Evidence from an Internal Exposure Study

Current Phthalate Exposure Risks of Rural Population in the Northwest China: Evidence from an Internal Exposure Study

Association between urinary phthalates and phthalate metabolites and cancer risk: A systematic review and meta-analysis

Relationship between the use of plastics in refrigerator food storage and urine phthalate metabolites: the Korean National Environmental Health Survey (KoNEHS) cycle 3

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