Effects of exposure to air pollution on acute cardiovascular and respiratory admissions to the hospital and early mortality at emergency department

Żyrek, Dawid; Krzemińska, Anastasija; Żyrek, Nina; Wajda, Andrzej; Pabian, Wojciech; Pacholski, Michał; Sokolski, Mateusz; Zymliński, Robert

doi:10.17219/acem/149400

Cited by 3 publications

(2 citation statements)

References 27 publications

(32 reference statements)

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“…Prolonged exposure to air pollutants poses a threat to human health and the quality of life [ 1 , 2 ]. Numerous epidemiological studies have demonstrated that exposure to airborne particulate matter (PM) is associated with a significant increase in hospitalization and mortality rates [ 3 , 4 ]. In 2013, the International Agency for Research on Cancer classified PM as a Group 1 carcinogen to humans [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Particulate Matter Elevates Ocular Inflammation and Endoplasmic Reticulum Stress in Human Retinal Pigmented Epithelium Cells

Jeong

Shin

Lee

et al. 2023

IJERPH

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Because of their exposure to air, eyes can come into contact with air pollutants such as particulate matter (PM), which may cause severe ocular pathologies. Prolonged ocular PM exposure may increase inflammation and endoplasmic reticulum stress in the retina. Herein, we investigated whether PM exposure induces ocular inflammation and endoplasmic reticulum (ER) stress-related cellular responses in human retinal epithelium-19 (ARPE-19) cells. To understand how PM promotes ocular inflammation, we monitored the activation of the mitogen-activated protein kinase (MAPK)/nuclear factor kappa beta (NFκB) axis and the expression of key inflammatory mRNAs. We also measured the upregulation of signature components for the ER-related unfolded protein response (UPR) pathways, as well as intracellular calcium ([Ca2+]i) levels, as readouts for ER stress induction following PM exposure. Ocular PM exposure significantly elevated the expression of multiple cytokine mRNAs and increased phosphorylation levels of NFκB-MAPK axis in a PM dose-dependent manner. Moreover, incubation with PM significantly increased [Ca2+]i levels and the expression of UPR-related proteins, which indicated ER stress resulting from cell hypoxia, and upregulation of hypoxic adaptation mechanisms such as the ER-associated UPR pathways. Our study demonstrated that ocular PM exposure increased inflammation in ARPE-19 cells, by activating the MAPK/NFκB axis and cytokine mRNA expression, while also inducing ER stress and stress adaptation responses. These findings may provide helpful insight into clinical and non-clinical research examining the role of PM exposure in ocular pathophysiology and delineating its underlying molecular mechanisms.

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Section: Introductionmentioning

confidence: 99%

Particulate Matter Elevates Ocular Inflammation and Endoplasmic Reticulum Stress in Human Retinal Pigmented Epithelium Cells

Jeong

Shin

Lee

et al. 2023

IJERPH

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“…Previous studies demonstrated that short-term exposure to air pollutants could cause various adverse health effects in people of different ages, such as respiratory and cardiovascular diseases [ 1 – 5 ]. Children have immature respiratory development, narrow bronchi, higher lung ventilation rates and lower immune capacity [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Short-term effects of air pollution on hospitalization for acute lower respiratory infections in children: a time-series analysis study from Lanzhou, China

Zhang,

Ling,

Zhang

et al. 2023

BMC Public Health

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Background Short-term exposure to air pollution is associated with acute lower respiratory infections (ALRI) in children. We investigated the relationship between hospitalization for ALRI in children and air pollutant concentrations from January 1, 2014 to December 31, 2020 in Lanzhou City. Methods We collected data on air pollutant concentrations and children’s hospitalization data during the study period. A time series regression analysis was used to assess the short-term effects of air pollutants on ALRI in children, and subgroup analyses and sensitivity analyses were performed. Results A total of 51,206 children with ALRI were studied, including 40,126 cases of pneumonia and 11,080 cases of bronchiolitis. The results of the study revealed that PM2.5, PM10, SO2 and NO2 were significantly associated with hospitalization for ALRI in children aged 0–14 years. For each 10 µg/m3 increase in air pollutant concentration in lag0-7, the relative risk of ALRI hospitalization in children due to PM2.5, PM10, SO2 and NO2 increased by 1.089 (95%CI:1.075, 1.103), 1.018 (95%CI:1.014, 1.021), 1.186 (95%CI:1.154. 1.219) and 1.149 (95%CI:1.130, 1.168), respectively. Conclusions PM2.5, PM10, SO2 and NO2 short-term exposures were positively associated with ALRI, pneumonia and bronchiolitis hospitalizations in Lanzhou, China. Local governments should make efforts to improve urban ambient air quality conditions to reduce hospitalization rates for childhood respiratory diseases.

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Atmosphere particulate matter and respiratory diseases during COVID-19 in Korea

Hong,

Bang,

Kim

et al. 2024

Sci Rep

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We aimed to examine the impact of COVID-19 non-pharmaceutical interventions (NPIs) on the relationship between air pollutants and hospital admissions for respiratory and non-respiratory diseases in six metropolitan cities in South Korea. This study compared the associations between particulate matter (PM10 and PM2.5) and hospital admission for respiratory and non-respiratory diseases before (2016–2019) and during (2020) the implementation of COVID-19 NPIs by using distributed lag non-linear models. In the Pre-COVID-19 period, the association between PM10 and admission risk for asthma and COPD showed an inverted U-shaped pattern. For PM2.5, S-shaped and inverted U-shaped changes were observed in asthma and COPD, respectively. Extremely high and low levels of PM10 and extremely low levels of PM2.5 significantly decreased the risk of admission for asthma and COPD. In the Post-COVID-19 outbreak period, the overall cumulative relationship between PM10 and PM2.5 and respiratory diseases and the effects of extreme levels of PM10 and PM2.5 on respiratory diseases were completely changed. For non-respiratory diseases, PM10 and PM2.5 were statistically insignificant for admission risk during both periods. Our study may provide evidence that implementing NPIs and reducing PM10 and PM2.5 exposure during the COVID-19 pandemic has contributed to reducing hospital admissions for environment-based respiratory diseases.

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Effects of exposure to air pollution on acute cardiovascular and respiratory admissions to the hospital and early mortality at emergency department

Abstract: Żyrek D, Krzemińska A, Żyrek N, et al. Effects of exposure to air pollution on acute cardiovascular and respiratory admissions to the hospital and early mortality at emergency department [published online ahead of print on May 11, 2022].

Cited by 3 publications

References 27 publications

Particulate Matter Elevates Ocular Inflammation and Endoplasmic Reticulum Stress in Human Retinal Pigmented Epithelium Cells

Particulate Matter Elevates Ocular Inflammation and Endoplasmic Reticulum Stress in Human Retinal Pigmented Epithelium Cells

Short-term effects of air pollution on hospitalization for acute lower respiratory infections in children: a time-series analysis study from Lanzhou, China

Atmosphere particulate matter and respiratory diseases during COVID-19 in Korea

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