Effects of experimental variables on the synthesis of porous matrices

Gómez, Cesar Gerardo; Álvarez, Cecilia; Strumia, Miriam Cristina; Rivas, B. L.; Reyes, Pablo

doi:10.1002/1097-4628(20010131)79:5<920::aid-app160>3.3.co;2-c

Cited by 3 publications

(8 citation statements)

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“…When evaluating the ability of polymeric hydrogels to function in a particular application, the hydrogel swelling behavior constitutes one of the most important characteristics. [26][27] Gels with a loose network will take up more water and exhibit high swelling ratios. Swelling studies were carried out on polymer 3 and 4 before and after chemical crosslinking with DT and MT, as shown in Figure 6(A) and 6(B).…”

Section: Resultsmentioning

confidence: 99%

Design of Polyphosphazene Hydrogels with Improved Structural Properties by Use of Star‐Shaped Multithiol Crosslinkers

Potta

Chun²,

Song³

2011

Macromolecular Bioscience

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The feasibility of using a star-shaped crosslinker to produce a hydrogel with controlled mechanical properties and degradation rates was investigated. The aqueous blends of functional polymers and crosslinkers formed a solution at low temperature and a hydrogel with desired mechanical properties at body temperature. The introduction of star-shaped crosslinkers affected the microscopic and macroscopic properties of the hydrogel. The fabricated hydrogels could be suitable for many potential biomedical applications because of their injectability, tunable mechanical properties, controlled degradation rate and gel formation under physiological conditions.

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Section: Resultsmentioning

confidence: 99%

Design of Polyphosphazene Hydrogels with Improved Structural Properties by Use of Star‐Shaped Multithiol Crosslinkers

Potta

Chun²,

Song³

2011

Macromolecular Bioscience

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“…When cyclohexane was used, the drainage time was 1 h. Then the wet samples were weighed in an analytical scale and the weights were measured at different evaporation times (each 15 s for 7-8 min after the sample was removed from the chamber). The data were processed using a plot of weight of wet sample (g) versus evaporation time (s), taking the weight of the sample in swollen state (W sw ) at time zero, which is achieved by extrapolation [14]. Subsequently, the samples were dried in a oven at 70 °C for 48 h and weighed to obtain the weight of the dry sample (W dry ).…”

Section: Reagents and Methodsmentioning

confidence: 99%

“…The H parameter was obtained using both swelling ratios (q w and q v ), which reflects the balance between swelling liquid sorbed and polymer network expansion of copolymers. A high H value is indicative of a high retention of liquid with a low stretching degree, which is the ideal condition for macroporous networks with a rigid network [14]. Therefore, this parameter is closely related to the matrix porosity.…”

Section: Characterization Of the Copolymer Obtained At 85°cmentioning

confidence: 99%

“…Derivates have the major advantages of good biocompatibility and moderate degree of swelling in water, and are biologically inertia. Recently, we have studied the influence of synthesis conditions by suspension polymerization on porous morphology of the polymeric networks [14]. The synthesis conditions studied included porogen type, radical initiator percentage, polymerization temperature and monomers type.…”

Section: Introductionmentioning

confidence: 99%

“…This matrix was obtained under the same polymerization conditions previously studied and reported [14], when EGDMA was used as the crosslinking agent.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of a triacrylate crosslinking agent and its use in the preparation of macroporous polymers

Gómez¹,

Strumia²

2001

Polymer Bulletin

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A triacrylate crosslinking agent, 2, 2', 2" -nitrilotriethyl triacrylate (NTETA), was synthesized through an original procedure from triethanolamine by a reaction with acryloyl chloride. Hydrophilic polymer supports were prepared by suspension copolymerization of 2-hydroxyethyl methacrylate (HEMA) with NTETA in an aqueous medium in the presence of cyclohexane (Cyc) as inert diluent. A new macroporous polymer, at a polymerization temperature of 85°C, was obtained. Porous properties of this copolymer were studied by swelling, mercury porosimetry and scanning electronic microscopy (SEM).

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Heterogeneous Structures in the Synthesis of Hydrophobic Lauryl Acrylate-Styrene-Ethylene Glycol Dimethacrylate Copolymer Particles

Ren

Luan

2010

International Journal of Polymeric Materials

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Novel crosslinked hydrophobic lauryl acrylate-styrene-ethylene glycol dimethacrylate copolymer particles were synthesized with heterogeneous structures by radical suspension copolymerization with benzoyl peroxide as the initiator. Ethylene glycol dimethacrylate was used as a crosslinking agent; toluene, cyclohexanol, 1-octanol and liquid paraffin were used as porogens. The effects of the crosslinking monomer and porogens on the morphologies of the copolymer microspheres were investigated. The copolymers were characterized by FTIR, SEM and swelling in toluene. Permanent pores remained in the dried polymeric particles prepared with nonsolvating porogens at certain crosslink densities as indicated by SEM pictures. The results of swelling revealed that 1-octanol was the most effective porogen, leading to the LA-S-EGDMA copolymer particles with maximum porosity and optimized spheric morphology. Furthermore, lower crosslink density and higher porogen contents promote the formation of porous morphology. INTRODUCTIONThe applications of methacrylic ester crosslinked polymers with permanently porous structures have attracted increasing attention all over the world. Exploitation occurs in areas a diverse as chromatography, polymer-supported catalysts, ion recovery [1], water treatment and purification [2][3][4][5]. For many applications it is important to utilize a porous resin with a high surface area. The formation conditions of porous (heterogeneous) structures in resin have been the subject of both applied and fundamental research for many years. As early as the end of the 1950s, Du s sek [6], Kunin [7,8], and Millar et al. [9][10][11] had already discovered this polymerization technique. According to the present reports [12][13][14][15][16][17][18][19][20][21][22][23][24], it was concluded that porous matrices can be obtained by suspension copolymerization, using monovinylic monomers and crosslinking reagents in the presence of inert porogens. These porogens may be extracted after polymerization, leaving holes or pores in the copolymer structures. Good solvents, nonsolvents, polymeric solvents, or mixtures of them may be used as porogens, leading to different kinds of pore size distributions.A variety of acrylic ester resins with different specific areas and porosity had been prepared by varying the type and ratio of porogen at a given condition [13,[25][26][27][28][29]. However, the preparation of perfusion particles was complicated, and this method was most used in trimethylolpropane trimethacrylate, 2-hydroxyethyl methacrylate, EGDMA, or methacrylate systems, and long alkyl chain acrylates systems have not been reported. Furthermore, the choice of polymerization conditions and experimental optimization must be specific for each chosen monomer system [20]. So it is necessary to further study.In our work, a novel hydrophobic porous copolymer, lauryl acrylatestyrene-ethylene glycol dimethacrylate copolymer, was prepared by the suspension polymerization technique in the presence of porogens. The effect of the independen...

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Effects of experimental variables on the synthesis of porous matrices

Cited by 3 publications

References 0 publications

Design of Polyphosphazene Hydrogels with Improved Structural Properties by Use of Star‐Shaped Multithiol Crosslinkers

Design of Polyphosphazene Hydrogels with Improved Structural Properties by Use of Star‐Shaped Multithiol Crosslinkers

Synthesis of a triacrylate crosslinking agent and its use in the preparation of macroporous polymers

Heterogeneous Structures in the Synthesis of Hydrophobic Lauryl Acrylate-Styrene-Ethylene Glycol Dimethacrylate Copolymer Particles

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