Decades of studies on wildlife-habitat relationships have provided important insights into the habitat requisites for many game and nongame species. Many species of conservation or management importance are area or edge sensitive, or need interspersion of habitat requisites to maintain viable populations; however, most habitat suitability models do not incorporate spatial relationships or landscape attributes. Our objective was to develop landscape-level habitat suitability models for 10 species in the Central Hardwoods Region of the Midwestern United States: American woodcock (Scolopax minor), cerulean warbler (Dendroica cerulea), Henslow's sparrow (Ammodramus henslowii), Indiana bat (Myotis sodalis), northern bobwhite (Colinus virginianus), ruffed grouse (Bonasa umbellus), timber rattlesnake (Crotalus horridus), wood thrush (Hylocichla mustelina), worm-eating warbler (Helmitheros vermivorus), and yellow-breasted chat (Icteria virens). All models included spatially explicit variables and relationships based on the best available empirical data and expert opinion. We provide an overview of habitat characteristics for each species, discuss the habitat variables used in each model, and provide supporting reference materials for all assumed relationships between quantity of a resource and quality for each species modeled. The models are included in a stand-alone software package, Landscape HSImodels version 2