Effects of exogenous zinc supplementation on intestinal epithelial repair in vitro

Abstract

Zinc may promote intestinal epithelial wound healing by enhancement of epithelial cell restitution, the initial step of epithelial wound healing. Zinc supplementation may improve epithelial repair; however, excessive amounts of zinc may cause tissue injury and impair epithelial wound healing.

Effect of Therapeutic Dietary Regimen on Wound Healing For Patients with Moderate Degree Burn

“…In addition, the study done byWilliams (2003) reported that deficiency of zinc may decrease rates of fibroplasia, epithelialization, and collagen synthesis as well as wound strength and impair immune response, increasing susceptibility to recurrent infections (43) . This finding was similarly to the finding of the study done by Kohn (2000) and Cario (2000) (72,73) . Moreover, Voelker (2000) reported that copper-induced proliferation of endothelial cells and thus on consequence promotes wound healing.…”

Zinc Alters Cytoskeletal Integrity and Migration in Colon Cancer Cells

“…Our current knowledge is thus only indirect; i.e. acquired from studies on the effects of zinc supplementation in zinc-deficiencies such as inflammatory bowel disease and others (3). On the other hand, it has been demonstrated that externally supplied zinc inhibits the growth and proliferation of several types of tumor cells, including colon cancer cells (5,7,11).…”

Structure, Properties, and Engineering of the Major Zinc Binding Site on Human Albumin

“…Zn 2ϩ concentrations above 72 M were toxic to cells cultured in Dulbecco's modified Eagle's medium supplemented with 10% newborn calf serum (supplemental Fig. S10, A and B), as seen by cell rounding, loss of adherence, and necrotic cell death, effects similar to those of Zn 2ϩ on other cell types (32,33). Physiological concentrations of rHA (600 M) were sufficient to completely abolish the adverse effects of Zn 2ϩ on hepatocytes, even at Zn 2ϩ concentrations as high as 600 M (Fig.…”