Effects of Exogenous Intravenous Glucose on Plasma Glucose and Lipid Homeostasis in Anesthetized Children

A novel isotonic-balanced electrolyte solution with 1% glucose for intraoperative fluid therapy in children: results of a prospective multicentre observational post-authorization safety study (PASS)

“…It is a well‐known fact that a lack of glucose supply enhances lipolysis leading to ketogenesis. This is not automatically accompanied by hypoglycemia (21–24). In this context, our study shows firstly that the incidence of hypoglycemia prior to induction of anesthesia is very low (<1%) when the preoperative period of starvation is short and secondly that the intravenous infusion of 1% glucose is sufficient to maintain plasma glucose concentrations within the physiologic range and to prevent metabolic acidosis from ketoacidosis.…”

Perioperative blood glucose in a paediatric daycase facility: Effects of fasting and maintenance fluid

“…Despite the liberalisation and reduction in the duration of preoperative fasting in the 1990s, [1] most children in developing countries continue to undergo prolonged preoperative fast. [2][3][4] Although several clinicians have reported maintenance of normoglycaemia preoperatively, and hyperglycaemic response to surgery and anaesthesia in healthy children in spite of fasting; [5][6][7][8][9][10][11][12][13][14] others have observed hypoglycaemia in a significant minority. [3,[15][16][17][18][19][20][21][22][23] Failure to demonstrate hyperglycaemia or outright hypoglycaemic response to anaesthesia and surgery has been reported by a few.…”

“…These include 5%, 2.5%, 2%, and 1%. [14][15][16][17][18][19][20][21][22][23][24] However, these are not commercially available in many centres in the sub-Sahara and the pharmacy departments may not be adequately equipped to handle production of these fluids. Currently 4.3% dextrose in 0.18% saline (DS) is the fluid being used in many centres in Nigeria for paediatric perioperative fluid management.…”

Is There Any Difference in Anesthetic Management of Biliary Atresia and Glycogen Storage Disease Patients Undergoing Liver Transplantation?

“…Our results show that administration of 2.7 Ϯ 1.9 and 2.5 Ϯ 1.1 mg/kg/min in the GI and GII groups, only one third to one half of the recommended doses [12], had resulted in hyperglycemia (Fig. 1), while such doses given to children without cirrhosis were normoglycemic during tympanoplasty [17]. The cause of the difference is not clear; it may probably be due to the fact that LT is a more stressful surgical procedure than tympanoplasty and LT patients received two doses of methylprednisolone intraoperatively.…”