Effects of exogenous hydrogen sulfide on the proliferation and invasion of human Bladder cancer cells

Liu, Hui; Chang, Junkai; Zhao, Zhenhua; Yang, Li; Hou, Jingli

doi:10.4103/jcrt.jcrt_423_17

Cited by 15 publications

(20 citation statements)

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“…However, in contrast, and despite the anticancer efficacy in various types of cancer cells (e.g., gastric carcinoma, renal tumor), other studies have shown that H 2 S may induce tumor cell proliferation, and migration, as well as angiogenesis, via inhibiting apoptosis (122–124). Jia et al observed hepatoma cell suppression when CBS/H 2 S pathway was inhibited (125).…”

Section: Biological Properties Of Hydrogen Sulfidementioning

confidence: 96%

Biological Effects of Thermal Water-Associated Hydrogen Sulfide on Human Airways and Associated Immune Cells: Implications for Respiratory Diseases

Viegas

Esteves

Cardoso

et al. 2019

Front. Public Health

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Natural mineral (thermal) waters have been used for centuries as treatment for various diseases. However, the scientific background of such therapeutic action is mostly empiric and based on knowledge acquired over time. Among the various types of natural mineral waters, sulfurous thermal waters (STWs) are the most common type in the center of Portugal. STWs are characterized by high pH, poor mineralization, and the presence of several ions and salts, such as bicarbonate, sodium, fluoride, silica, and carbonate. Furthermore, these waters are indicated as a good option for the treatment of various illnesses, namely respiratory diseases (e.g., allergic rhinitis, asthma, and chronic obstructive pulmonary disease). From the sulfide species present in these waters, hydrogen sulfide (H 2 S) stands out due to its abundance. In healthy conditions, H 2 S-related enzymes (e.g., cystathionine β-synthase and cystathionine γ-lyase) are expressed in human lungs, where they have mucolytic, antioxidant, anti-inflammatory, and antibacterial roles, thus contributing to airway epithelium homeostasis. These roles occur mainly through S-sulfhydration, a post-translational modification through which H 2 S is able to change the activity of several targets, such as ion channels, second messengers, proteins, among others. However, in respiratory diseases the metabolism of H 2 S is altered, which seems to contribute somehow to the respiratory deterioration. Moreover, H 2 S has been regarded as a good biomarker of airway dysfunction and severity, and can be measured in serum, sputum, and exhaled air. Hence, in this review we will recapitulate the effects of STWs on lung epithelial-immune crosstalk through the action of its main component, H 2 S.

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Section: Biological Properties Of Hydrogen Sulfidementioning

confidence: 96%

Biological Effects of Thermal Water-Associated Hydrogen Sulfide on Human Airways and Associated Immune Cells: Implications for Respiratory Diseases

Viegas

Esteves

Cardoso

et al. 2019

Front. Public Health

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“…Besides, treatment of thyroid cancer cells with 25-50 µM NaHS effectively enhances migration and invasion by activating PI3K/AKT/mTOR and MAPK pathways [127]. The H2S donor-mediated cell migration has also been confirmed by elevated levels of MMP-2 and -9 protein levels in bladder cancer and esophageal carcinoma following administration of NaHS [18,175,188]. The cell migration-induced activation of AKT pathways have also been reported in multiple myeloma cells following the administration of NaHS [174].…”

Section: H 2 S Donor Enhances Cell Migration and Invasionmentioning

confidence: 99%

Role of hydrogen sulfide donors in cancer development and progression

et al. 2021

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In recent years, a vast number of potential cancer therapeutic targets have emerged. However, developing efficient and effective drugs for the targets is of major concern. Hydrogen sulfide (H2S), one of the three known gasotransmitters, is involved in the regulation of various cellular activities such as autophagy, apoptosis, migration, and proliferation. Low production of H2S has been identified in numerous cancer types. Treating cancer cells with H2S donors is the common experimental technique used to improve H2S levels; however, the outcome depends on the concentration/dose, time, cell type, and sometimes the drug used. Both natural and synthesized donors are available for this purpose, although their effects vary independently ranging from strong cancer suppressors to promoters. Nonetheless, numerous signaling pathways have been reported to be altered following the treatments with H2S donors which suggest their potential in cancer treatment. This review will analyze the potential of H2S donors in cancer therapy by summarizing key cellular processes and mechanisms involved.

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“…Exogenous H 2 S also significantly increased cell proliferation and invasion, and MMP-2 and MMP-9 protein expression in the EJ human bladder cancer cell line. These events were increased with higher exogenous H 2 S dosages, suggesting that H 2 S increases the proliferative, invasive, and metastatic capacities of UBC [ 62 ].…”

Section: H 2 S and Cancermentioning

confidence: 99%

Molecular Functions of Hydrogen Sulfide in Cancer

et al. 2021

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Hydrogen sulfide (H2S) is a gasotransmitter that exerts a multitude of functions in both physiologic and pathophysiologic processes. H2S-synthesizing enzymes are increased in a variety of human malignancies, including colon, prostate, breast, renal, urothelial, ovarian, oral squamous cell, and thyroid cancers. In cancer, H2S promotes tumor growth, cellular and mitochondrial bioenergetics, migration, invasion, angiogenesis, tumor blood flow, metastasis, epithelia–mesenchymal transition, DNA repair, protein sulfhydration, and chemotherapy resistance Additionally, in some malignancies, increased H2S-synthesizing enzyme expression correlates with a worse prognosis and a higher tumor stage. Here we review the role of H2S in cancer, with an emphasis on the molecular mechanisms by which H2S promotes cancer development, progression, dedifferentiation, and metastasis.

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Effects of exogenous hydrogen sulfide on the proliferation and invasion of human Bladder cancer cells

Abstract: Exogenous H2S may promote cell proliferation and invasion by upregulating the expression level of MMP2 and MMP9 in human bladder cancer EJ cells.

Cited by 15 publications

References 0 publications

Biological Effects of Thermal Water-Associated Hydrogen Sulfide on Human Airways and Associated Immune Cells: Implications for Respiratory Diseases

Biological Effects of Thermal Water-Associated Hydrogen Sulfide on Human Airways and Associated Immune Cells: Implications for Respiratory Diseases

Role of hydrogen sulfide donors in cancer development and progression

Molecular Functions of Hydrogen Sulfide in Cancer

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