Effects of exhaust pollutant sulfur dioxide on lipid metabolism of guinea pig organs.

Haider, Syed Saleem

doi:10.2486/indhealth.23.81

Cited by 24 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, studies showed endogenous SO 2 pathways in tissues of rats including cardiovascular tissues [ 3 , 4 ]. The physiological effects of SO 2 were also confirmed, including vasodilation [ 4 – 6 ], negative regulation of cardiac function [ 7 ], and regulation of lipid metabolism [ 8 – 10 ]. Also, the pathophysiologic role of SO 2 in the processes of vascular structural remodeling (VSR) [ 11 , 12 ], inflammatory response [ 13 ], and oxidative response was indicated [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Endogenous Sulfur Dioxide in Regulating Vascular Structural Remodeling in Hypertension

Liu

Huang

Chen

et al. 2016

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Sulfur dioxide (SO2), an emerging gasotransmitter, was discovered to be endogenously generated in the cardiovascular system. Recently, the physiological effects of endogenous SO2 were confirmed. Vascular structural remodeling (VSR), an important pathological change in many cardiovascular diseases, plays a crucial role in the pathogenesis of the diseases. Here, the authors reviewed the research progress of endogenous SO2 in regulating VSR by searching the relevant data from PubMed and Medline. In spontaneously hypertensive rats (SHRs) and pulmonary hypertensive rats, SO2/aspartate aminotransferase (AAT) pathway was significantly altered. SO2 inhibited vascular smooth muscle cell (VSMC) proliferation, promoted apoptosis, inhibited the synthesis of extracellular collagen but promoted its degradation, and enhanced antioxidative capacity, thereby playing a significant role in attenuating VSR. However, the detailed mechanisms needed to be further explored. Further studies in this field would be important for the better understanding of the pathogenesis of systemic hypertension and pulmonary hypertension. Also, clinical trials are needed to demonstrate if SO2 would be a potential therapeutic target in cardiovascular diseases.

show abstract

Section: Introductionmentioning

confidence: 99%

Role of Endogenous Sulfur Dioxide in Regulating Vascular Structural Remodeling in Hypertension

Liu

Huang

Chen

et al. 2016

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…Sulfur dioxide (SO 2 ) is a major toxic gas and environmental pollutant [1]. Its toxicity has been extensively investigated in humans, animals, and plants [2].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of sulfur dioxide within the nucleus tractus solitarii of rats

Li¹,

Gao

Yang³

et al. 2019

NeuroReport

View full text Add to dashboard Cite

This study was designed to investigate the cardiovascular effects of sulfur dioxide within the nucleus tractus solitarii. Sulfur dioxide or artificial cerebrospinal fluid was unilaterally applied into the nucleus tractus solitarii of rats, and the effects on blood pressure, heart rate, and arterial baroreflex sensitivity (ABR) were determined. To explore the mechanisms of the effects of intra-nucleus tractus solitarii sulfur dioxide, various inhibitors were applied prior to sulfur dioxide treatment. Unilateral microinjection of sulfur dioxide produced a dose-dependent decrease in blood pressure in anesthetized rats. Significant decreases in heart rate were also seen after unilateral microinjection of 20 and 200 pmol of sulfur dioxide ( P < 0.05). Bilateral microinjection of sulfur dioxide into the nucleus tractus solitarii significantly decreased blood pressure and heart rate and also attenuated ABR. Pretreatment with glibenclamide or nicardipine within the nucleus tractus solitarii did not alter the hypotension or bradycardia ( P > 0.05) induced by intra-nucleus tractus solitarii sulfur dioxide. Pretreatment with 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one, however, significantly attenuated this hypotension and bradycardia. Prior application of kynurenic acid or N (G)-Nitro- l -arginine methyl ester into the nucleus tractus solitarii partially diminished the hypotension and bradycardia induced by intra-nucleus tractus solitarii sulfur dioxide. Our present study shows that sulfur dioxide produces cardiovascular inhibitory effects in the nucleus tractus solitarii, predominantly mediated by glutamate receptors and the nitric oxide/cyclic GMP signal transduction pathway.

show abstract

“…SO 2 was also found to have a negative inotropic effect as observed on isolated perfused rat heart, which in turn affects the heart rate and left ventricular developed pressure (Zhang and Meng, 2012 ). Besides in the cardiovascular system, SO 2 was also found to be involved in lipid metabolism, possibly due to its oxidant effect (Haider, 1985 ; Lovati et al, 1996 ). More interestingly, aligned with the well-known antimicrobial activity of SO 2 and its derivatives, Nojima and colleagues have demonstrated that sulfite is a neutrophil mediator of host defense that in vivo administration of lipopolysaccharide (LPS) would trigger sulfite release from neutrophil and increase serum sulfite concentration in rats (Mitsuhashi et al, 1998 ).…”

Section: Introductionmentioning

confidence: 99%

SO2 Donors and Prodrugs, and Their Possible Applications: A Review

Wang¹,

Wang²

2018

Front. Chem.

View full text Add to dashboard Cite

SO2 is widely recognized as an air pollutant and is a known cause of acid rain. At a sufficiently high level, it also causes respiratory diseases. A much lesser known side of SO2 is its endogenous nature and possible physiological roles. There is mounting evidence that SO2 is produced during normal cellular metabolism and may possibly function as a signaling molecule in normal physiology. The latter aspect is still at the stage of being carefully examined as to the validity of classifying SO2 as a gasotransmitter with endogenous signaling roles. One difficulty in studying the biological and pharmacological roles of SO2 is the lack of adequate tools for its controllable and precise delivery. Traditional methods of using SO2 gas or mixed sulfite salts do not meet research need for several reasons. Therefore, there has been increasing attention on the need of developing SO2 donors or prodrugs that can be used as tools for the elucidation of SO2's physiological roles, pharmacological effects, and possible mechanism(s) of action. In this review, we aim to review basic sulfur chemistry in the context of sulfur signaling and various chemical strategies used for designing SO2 donors. We will also discuss potential pharmacological applications of SO2 donors, lay out desirable features for such donors and possibly prodrugs, analyze existing problems, and give our thoughts on research needs.

show abstract

Effects of exhaust pollutant sulfur dioxide on lipid metabolism of guinea pig organs.

Cited by 24 publications

References 12 publications

Role of Endogenous Sulfur Dioxide in Regulating Vascular Structural Remodeling in Hypertension

Role of Endogenous Sulfur Dioxide in Regulating Vascular Structural Remodeling in Hypertension

Inhibitory effects of sulfur dioxide within the nucleus tractus solitarii of rats

SO2 Donors and Prodrugs, and Their Possible Applications: A Review

Contact Info

Product

Resources

About