Effects of exercise training on carotid intima-media thickness in patients with type 2 diabetes and coronary artery disease. Influence of carotid plaques

Byrkjeland, Rune; Stensæth, Knut Haakon; Anderssen, Sigmund Alfred; Njerve, Ida Unhammer; Arnesen, Harald; Seljeflot, Ingebjørg; Solheim, Svein

doi:10.1186/s12933-016-0336-2

Cited by 55 publications

(62 citation statements)

References 38 publications

(53 reference statements)

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“…Moreover, there is a quantitative relationship between HbA1c levels and plaque texture in ultrasonic images of atherosclerotic patients [49], and in those without identified carotid plaques, beneficial effect of exercise training on carotid IMT progression has been demonstrated [50]. On the other hand, these favorable effects have not been always seen [51].…”

Section: Discussionmentioning

confidence: 99%

Clinical outcomes and glycaemic responses to different aerobic exercise training intensities in type II diabetes: a systematic review and meta-analysis

Grace

Chan

Giallauria³

et al. 2017

Cardiovasc Diabetol

106

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AimsTo establish if aerobic exercise training is associated with beneficial effects on clinical outcomes and glycaemic profile in people with type II diabetes.MethodsA systematic search was conducted to identify studies through a search of MEDLINE (1985 to Sept 1, 2016, Cochrane Controlled Trials Registry (1966 to Sept 1, 2016), CINAHL, SPORTDiscus and Science Citation Index. The search strategy included a mix of MeSH and free text terms for related key concepts. Searches were limited to prospective randomized or controlled trials of aerobic exercise training in humans with type II diabetes, aged >18 years, lasting >2 weeks.ResultsOur analysis included 27 studies (38 intervention groups) totalling 1372 participants, 737 exercise and 635 from control groups. The studies contain data from 39,435 patient-hours of exercise training. Our analyses showed improvements with exercise in glycosylated haemoglobin (HbA1C%) MD: −0.71%, 95% CI −1.11, −0.31; p value = 0.0005. There were significant moderator effects; for every additional week of exercise HbA1C% reduces between 0.009 and 0.04%, p = 0.002. For those exercising at vigorous intensity peak oxygen consumption (peak VO2) increased a further 0.64 and 5.98 ml/kg/min compared to those doing low or moderate intensity activity. Homeostatic model assessment of insulin resistance (HOMA-IR) was also improved with exercise MD: −1.02, 95% CI −1.77, −0.28; p value = 0.007; as was fasting serum glucose MD: −12.53 mmol/l, 95% CI −18.94, −6.23; p value <0.0001; and serum MD: −10.39 IU, 95% CI −17.25, −3.53; p value = 0.003.ConclusionsOur analysis support existing guidelines that for those who can tolerate it, exercise at higher intensity may offer superior fitness benefits and longer program duration will optimize reductions in HbA1C%.Electronic supplementary materialThe online version of this article (doi:10.1186/s12933-017-0518-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Clinical outcomes and glycaemic responses to different aerobic exercise training intensities in type II diabetes: a systematic review and meta-analysis

Grace

Chan

Giallauria³

et al. 2017

Cardiovasc Diabetol

106

View full text Add to dashboard Cite

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“…All studies were conducted in sedentary individuals. Eight studies recruited both male and female participants [28][29][30][31][32][33][34][35], three studies exclusively recruited male participants [36][37][38], and two studies recruited females exclusively [39,40]. Only 3 studies had a control group [28,35,38].…”

Section: Characteristics Of the Studies And Summary Of Outcome Measuresmentioning

confidence: 99%

“…RT on weight machines was used in one study with high intensity [31] and elastic resistance bands with low intensity were used in another study [39]; frequency of training was 3 days a week for 14 months and 5 days a week for 12 weeks, respectively. The usage of resources for combined training among the 11 studies was as follows: -7 studies used weight machines [28,32,33,[36][37][38]40] -2 free weights [29,30] -1 elastic resistance bands [34] -1 did not include information on the kind of exercise [35] The frequency of CT was most commonly 2 or 3 days per week and duration was between 4 weeks and 12 months.…”

Section: Characteristics Of the Studies And Summary Of Outcome Measuresmentioning

confidence: 99%

“…Two studies used a percentage of maximal voluntary contraction (MVC) [33,36], with a range between 55-80% MVC. Kilogram equivalents for resistance bands were used in two studies to prescribe intensity [34,39], one study used Borg's scale [30] and two studies did not report the intensity progression during the intervention period [35,38]. AT intensity was expressed as: -Percentage of maximal heart rate (HRmax) [28,32,35] -Percentage of heart rate reserve (HRR) [38, 40] -Percentage of maximal rate of oxygen consumption (VO 2 max) [34,36,37] or -Percentage of peak rate of oxygen consumption (VO 2 peak) [29,33] The intensity ranged from 60-90%.…”

Section: Characteristics Of the Studies And Summary Of Outcome Measuresmentioning

confidence: 99%

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Effects of Resistance and Combined training on Vascular Function in Type 2 Diabetes: A Systematic Review of Randomized Controlled Trials

Araújo¹,

Macedo²,

Barreto³

et al. 2018

Rev Diabet Stud

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■ AbstractBACKGROUND: Cardiovascular disease (CVD) is the main cause of mortality in type 2 diabetes (T2D). Exercise can reduce the risk factors associated with CVD in T2D patients. However, research evaluating its beneficial effects in these patients has used different measurement protocols and types of exercise, complicating comparison. AIM: To assess the effects of resistance training (RT) and combined training (CT) on the vascular function of T2D patients. METHODS: A database search (MEDLINE, Scopus, and Web of Science) was performed to identify relevant articles that were published up to August 2017. Only original studies evaluating the effects of RT or CT interventions on vascular function in T2D patients were included. The articles were reviewed independently by at least three reviewers. The Cochrane guidelines were used to assess the methodological quality of the studies. Fourteen studies were finally included. Two studies only used RT and twelve studies used CT as intervention strategy. RESULTS and CONCLUSIONS: The results show that resistance training is a useful means for primary treatment of vascular diseases and maintenance of vascular function in T2D patients. However, more studies are necessary to gain full knowledge of the beneficial effects and to identify tailored exercise plans to optimize these benefits. The information provided in this review may help to improve current treatment of vascular diseases in T2D patients and to design future studies.

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“…Likewise, Byrkjeland et al found no correlation between in LDLcholesterol and CIMT, inferring that increase in LDLcholesterol did not influence CIMT progression [12] . In contrast, Kota et al reported that glycemic parameters as FBG, and HbA1C collectively with lipid parameters were all significantly higher in diabetic patients with increased CIMT values [11] .…”

Section: Discussionmentioning

confidence: 94%

Chitotriosidase Enzyme Activity and miRNA-146a expression and their value as potential Biomarkers of subclinical Atherosclerosis in type 2 Diabetes Mellitus

Demerdash

El-Sharaby

AblelRaouf

2017

APALM

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Background: Type 2 diabetes T2DM is a common disease with increased mortality and morbidity due to vascular complications. Carotid Intimal-Medial Thickness (CIMT) is being used as a marker to assess subclinical atherosclerosis.MicroRNA (miR-146a) is a new discoveredbiomarker that regulates endothelial cell function and vascular inflammation, together with Chitotriosidase (CHIT1)enzyme being involved mainly in the immune and inflammatory responses.This study aimed to investigate an assumed association between CHIT1 activity and miR-146a gene expression in type 2 diabetes patients for detection of endothelial dysfunction and subclinical atherosclerosis, in association with CIMT.Material and Methods: 30 control subjects (group I) and 100 patients diagnosed as T2DMclassified according to CIMT results; group II (38 patient) with CIMT value less than 0.7mm and group III (62patients) with CIMT value more than 0.7mm. Plasma CHIT1 activity was measured fluorometricallyand quantitative Real Time PCR (qPCR) for miR-146a. Routine laboratory parameters such as blood glucose, lipid profile, glycated hemoglobin were also measured.Results: revealedCHIT1activity was significant high(p < 0.001) in group II and III diabetic patients compared to group I, also it waspositively correlated with CIMT and other parameters as glycemic control, lipid profile, duration of disease and blood pressure. On the other hand, plasma miR-146a was significantly reduced (p < 0.001) in group III and was negatively correlated with CIMT and other parameters. Conclusion:IncreasedCHIT1activity may be due to the associated changes in the relative gene expression of miRNA 146a in patients with increased CIMT above 1mm. Moreover, evaluation of microRNA 146a gene expression can be used as useful biomarker for detection of endothelial dysfunction and development of atherosclerosis in T2DM.

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Effects of exercise training on carotid intima-media thickness in patients with type 2 diabetes and coronary artery disease. Influence of carotid plaques

Cited by 55 publications

References 38 publications

Clinical outcomes and glycaemic responses to different aerobic exercise training intensities in type II diabetes: a systematic review and meta-analysis

Clinical outcomes and glycaemic responses to different aerobic exercise training intensities in type II diabetes: a systematic review and meta-analysis

Effects of Resistance and Combined training on Vascular Function in Type 2 Diabetes: A Systematic Review of Randomized Controlled Trials

Chitotriosidase Enzyme Activity and miRNA-146a expression and their value as potential Biomarkers of subclinical Atherosclerosis in type 2 Diabetes Mellitus

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