Effects of Exercise or Mechanical Stimulation on Bone Development and Bone Repair

Song, Lidan

doi:10.1155/2022/5372229

Cited by 10 publications

(5 citation statements)

References 78 publications

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“…Previous studies have highlighted the positive effects of exercise or mechanical stimulation on bone formation and regeneration in fracture scenarios. Therefore, we speculate that the alleviation of pain associated with critical size defects post-treatment enabled mice to improve their mobility, while appropriate mechanical cues further stimulated the osteogenic differentiation of progenitor cells and the bone regeneration process [ [84] , [85] , [86] ]. These findings strongly support the localized delivery of Spp1 and Cxcl12 via PCL scaffold as a potent therapeutic strategy for the clinical management of critical size bone defects.…”

Section: Resultsmentioning

confidence: 99%

Vascular restoration through local delivery of angiogenic factors stimulates bone regeneration in critical size defects

Fang,

Liu,

Wang

et al. 2024

Bioactive Materials

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Section: Resultsmentioning

confidence: 99%

Vascular restoration through local delivery of angiogenic factors stimulates bone regeneration in critical size defects

Fang,

Liu,

Wang

et al. 2024

Bioactive Materials

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“…Mechanical loading is closely associated with the development and regeneration of bone-cartilage. Several studies have focused on the regulatory role and mechanism of dynamic loading on Frontiers in Bioengineering and Biotechnology frontiersin.org Frontiers in Bioengineering and Biotechnology frontiersin.org chondrogenic differentiation of stem cells (Fahy et al, 2017;Song, 2022;Ma et al, 2022). Mechanical cues control chondrocyte homeostasis or hypertrophy and mineralization, depending on the timing of the load application (McDermott et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Periodic static compression of micro-strain pattern regulates endochondral bone formation

Cheng,

Zhao,

Han

et al. 2024

Front. Bioeng. Biotechnol.

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Introduction: Developmental engineering based on endochondral ossification has been proposed as a potential strategy for repairing of critical bone defects. Bone development is driven by growth plate-mediated endochondral ossification. Under physiological conditions, growth plate chondrocytes undergo compressive forces characterized by micro-mechanics, but the regulatory effect of micro-mechanical loading on endochondral bone formation has not been investigated.Methods: In this study, a periodic static compression (PSC) model characterized by micro-strain (with 0.5% strain) was designed to clarify the effects of biochemical/mechanical cues on endochondral bone formation. Hydrogel scaffolds loaded with bone marrow mesenchymal stem cells (BMSCs) were incubated in proliferation medium or chondrogenic medium, and PSC was performed continuously for 14 or 28 days. Subsequently, the scaffold pretreated for 28 days was implanted into rat femoral muscle pouches and femoral condylar defect sites. The chondrogenesis and bone defect repair were evaluated 4 or 10 weeks post-operation.Results: The results showed that PSC stimulation for 14 days significantly increased the number of COL II positive cells in proliferation medium. However, the chondrogenic efficiency of BMSCs was significantly improved in chondrogenic medium, with or without PSC application. The induced chondrocytes (ichondrocytes) spontaneously underwent hypertrophy and maturation, but long-term mechanical stimulation (loading for 28 days) significantly inhibited hypertrophy and mineralization in ichondrocytes. In the heterotopic ossification model, no chondrocytes were found and no significant difference in terms of mineral deposition in each group; However, 4 weeks after implantation into the femoral defect site, all scaffolds that were subjected to biochemical/mechanical cues, either solely or synergistically, showed typical chondrocytes and endochondral bone formation. In addition, simultaneous biochemical induction/mechanical loading significantly accelerated the bone regeneration.Discussion: Our findings suggest that microstrain mechanics, biochemical cues, and in vivo microenvironment synergistically regulate the differentiation fate of BMSCs. Meanwhile, this study shows the potential of micro-strain mechanics in the treatment of critical bone defects.

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“…163 Osteocytes exposed to FSS at 1.6 Pa (16 dyn/cm 2 ) increased Cx43 expression on the cell membrane, leading to the formation of hemichannels, thereby facilitating the release of PGE 2 and the construction of intercellular gap junctions. [163][164][165][166] Interestingly, mechanical stretching of osteoblasts can promote the phosphorylation level of Cx43 without affecting its mRNA expression. 167 Furthermore, the oscillating fluid flow facilitates the development of new gap junctions (GJs) between mouse osteocytes by an ERK1/2-MAPK-dependent mechanism, while the dye transfer between existing GJs remains unchanged.…”

Section: Mechanosensitive Structuresmentioning

confidence: 99%

Significance of mechanical loading in bone fracture healing, bone regeneration, and vascularization

Miri

Haugen

et al. 2023

J Tissue Eng

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In 1892, J.L. Wolff proposed that bone could respond to mechanical and biophysical stimuli as a dynamic organ. This theory presents a unique opportunity for investigations on bone and its potential to aid in tissue repair. Routine activities such as exercise or machinery application can exert mechanical loads on bone. Previous research has demonstrated that mechanical loading can affect the differentiation and development of mesenchymal tissue. However, the extent to which mechanical stimulation can help repair or generate bone tissue and the related mechanisms remain unclear. Four key cell types in bone tissue, including osteoblasts, osteoclasts, bone lining cells, and osteocytes, play critical roles in responding to mechanical stimuli, while other cell lineages such as myocytes, platelets, fibroblasts, endothelial cells, and chondrocytes also exhibit mechanosensitivity. Mechanical loading can regulate the biological functions of bone tissue through the mechanosensor of bone cells intraosseously, making it a potential target for fracture healing and bone regeneration. This review aims to clarify these issues and explain bone remodeling, structure dynamics, and mechano-transduction processes in response to mechanical loading. Loading of different magnitudes, frequencies, and types, such as dynamic versus static loads, are analyzed to determine the effects of mechanical stimulation on bone tissue structure and cellular function. Finally, the importance of vascularization in nutrient supply for bone healing and regeneration was further discussed.

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Effects of Exercise or Mechanical Stimulation on Bone Development and Bone Repair

Cited by 10 publications

References 78 publications

Vascular restoration through local delivery of angiogenic factors stimulates bone regeneration in critical size defects

Vascular restoration through local delivery of angiogenic factors stimulates bone regeneration in critical size defects

Periodic static compression of micro-strain pattern regulates endochondral bone formation

Significance of mechanical loading in bone fracture healing, bone regeneration, and vascularization

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