Effects of exercise on the levels of BDNF and executive function in adolescents

Azevedo, Kesley Pablo Morais de; Segundo, Victor Hugo de Oliveira; Medeiros, Gidyenne Christine Bandeira Silva de; Mata, Ádala Nayana de Sousa; García, Daniel Ángel; Leitão, José Carlos; Knackfuss, Maria Irany; Piuvezam, Grasiela

doi:10.1097/md.0000000000016445

Cited by 20 publications

(16 citation statements)

References 27 publications

(32 reference statements)

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“…However, the association of the Val66 Met genotype with BDNF serum or plasma levels in children, adolescents or adults, was not confirmed in other studies [ 12 , 25 , 26 ]. Peripheral level of BDNF depends on numerous factors such as age, gender, hormonal status, circadian variation, platelet count, diet and exercise [ 12 , 27 , 28 ]. This complex mechanism of regulation of BDNF levels could be the reason for the contradictory results regarding the association of the Val66Met polymorphism with peripheral BDNF levels.…”

Section: Discussionmentioning

confidence: 99%

Association of the brain-derived neurotrophic factor Val66Met polymorphism with body mass index, fasting glucose levels and lipid status in adolescents

Vidović

Maksimović

Novaković

et al. 2020

Balkan Journal of Medical Genetics

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Brain-derived neurotrophic factor (BDNF) has an important role in energy balance. It suppresses food intake, reduces hepatic glucose production and converts white fat into brown fat in adipose tissue, leading to energy dissipation, lowered blood glucose and a lean phenotype. Studies have shown that the single nucleotide polymorphism (SNP) Val66Met within BDNF may be associated with obesity, insulin sensitivity, type 2 diabetes mellitus (T2DM) and dyslipidemia. The objective of the study was to investigate the association of the Val66Met polymorphism with body mass index (BMI), fasting glucose levels and lipid profile in Serbian adolescents. The study included 308 randomly selected healthy adolescents, 153 (49.68%) boys and 155 girls (50.32%), 15 years of age. Data including age, gender, height, weight, lipid profile and fasting glucose were recorded. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. No association of this polymorphism was found with BMI and lipid profile. However, significant association was observed between this polymorphism and fasting blood glucose (FBG). Carriers of a Val/Val genotype had significantly higher mean values of fasting glucose level compared to carriers of Val/ Met and Met/Met genotypes (p = 0.01). To confirm these results multiple linear regression analysis was performed. Body mass index and gender were taken as covariates. Carriers of the Val/Val genotype had significantly higher levels of FBG (β = -0.152, p = 0.02). A statistically significant association between BMI and glucose level was also observed (β = 0.124,p = 0.033). This polymorphism could be associated with fasting glucose level in Serbian adolescents, thus further research would be of great interest to validate these results.

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Section: Discussionmentioning

confidence: 99%

Association of the brain-derived neurotrophic factor Val66Met polymorphism with body mass index, fasting glucose levels and lipid status in adolescents

Vidović

Maksimović

Novaković

et al. 2020

Balkan Journal of Medical Genetics

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“…Specifically, BDNF might be a key mediator of the effects of exercise on structural brain markers of depression. An accumulating number of studies have demonstrated that exercise training results in significant upregulation of BDNF and elevation of neurogenesis in human and animal models (de Azevedo et al., 2019; Liu & Nusslock, 2018; Pereira et al., 2013; Sleiman et al., 2016; Wrann et al., 2013). There are also some clinical trials evaluating anti‐depressive effects of exercise training in patients with breast cancer and its impact on the serum levels of BDNF (Witlox et al., 2019).…”

Section: Discussionmentioning

confidence: 99%

Combination of quercetin and exercise training attenuates depression in rats with 1,2‐dimethylhydrazine‐induced colorectal cancer: Possible involvement of inflammation and BDNF signalling

Sadighparvar

Darband

Yousefi

et al. 2020

Experimental Physiology

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New Findings What is the central question of this study?What are the alleviative effects of the combination of exercise training and quercetin supplementation on colorectal cancer‐related depression in rats with 1,2‐dimethylhydrazine‐induced colorectal cancer and what is the corresponding signalling pathway? What is the main finding and its importance?We showed that the combination of exercise training and quercetin supplementation resulted in a significant decrease in tumour incidence and improvement in depressive‐like behaviours through modulation of the BDNF/TrKβ/β‐catenin axis in the prefrontal cortex. Abstract In addition to physical problems, depression is considered to be one of the most important challenges for patients with various types of cancers, particularly colorectal cancer. Inflammation and upregulation of brain neurotrophic factors are two major links between cancer and depression. In this study, we aimed to evaluate the alleviative effects of quercetin and exercise training on depressive‐like behaviours in rats with 1,2‐dimethylhydrazine (DMH)‐induced colorectal cancer and to investigate the underlying mechanisms. Animals were assigned into the following five groups: (i) control group; (ii) DMH (20 mg kg−1 s.c., once a week for 10 weeks); (iii) DMH for 10 weeks, followed by quercetin (50 mg kg−1 p.o., once per week) for 12 weeks; (iv) DMH for 10 weeks, followed by exercise training for 12 weeks; and (v) DMH for 10 weeks, followed by quercetin and exercise training for 12 weeks. The DMH‐treated rats showed an increase in depressive‐like behaviours in both open field and forced swimming tests. Histopathological examination revealed neural damage and reduced Nissl bodies in the prefrontal cortex. In addition, administration of DMH increased inflammatory cytokines in the serum, prefrontal cortex and tumour tissues and decreased the expression levels of brain‐derived neurotrophic factor (BDNF), tyrosine kinase β receptor (TrKβ) and β‐catenin in the cortex. In contrast, treatment with quercetin and exercise training effectively alleviated all the above‐mentioned DMH‐associated behavioural, biochemical and histopathological alterations without changing its anti‐tumour activity. Taken together, our results show that the combination of quercetin and exercise training exerts potent anti‐tumour and anti‐depressive effects through suppression of inflammation and upregulation of the BDNF/TrKβ/β‐catenin axis in the prefrontal cortex.

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“…In addition, there is much heterogeneity in study designs with exercise training, as has been noted in other systematic review protocols. [32,33]…”

Section: Discussionmentioning

confidence: 99%

Can people self-select an exercise intensity sufficient to enhance muscular strength during weight training?

Piuvezam

Kpm

et al. 2019

Medicine

Self Cite

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Background:Previous studies have reported that self-selection of the training intensity can be an interesting strategy to improve adherence in aerobic exercise programs. However, its effectiveness with weight training has not been systematically reviewed and remains unclear. In this study, we will describe a systematic review protocol that aims to investigate if people are able to self-select an intensity during weight training sufficient to enhance muscular strength.Methods:This protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. In this study, we will search the following electronic databases: PubMed, Science Direct, Scopus, Web of Science and SPORTDiscus. Intervention studies with at least one weight training session performed at self-selected intensity, with people from both genders and all age ranges will be included. The Downs & Black checklist will be used for methodological quality assessment. Two experienced reviewers will independently perform the selection of studies, data extraction, and evaluation of the methodological quality.Conclusion:This will be the first systematic review describing the results of weight training intervention studies with self-selected intensity. This study will provide high-quality and reliable evidence for health professionals and may direct methodological recommendations for further studies.PROSPERO registration number:CRD42019120323

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Effects of exercise on the levels of BDNF and executive function in adolescents

Abstract: Supplemental Digital Content is available in the text

Cited by 20 publications

References 27 publications

Association of the brain-derived neurotrophic factor Val66Met polymorphism with body mass index, fasting glucose levels and lipid status in adolescents

Association of the brain-derived neurotrophic factor Val66Met polymorphism with body mass index, fasting glucose levels and lipid status in adolescents

Combination of quercetin and exercise training attenuates depression in rats with 1,2‐dimethylhydrazine‐induced colorectal cancer: Possible involvement of inflammation and BDNF signalling

Can people self-select an exercise intensity sufficient to enhance muscular strength during weight training?

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