Effects of exercise on practolol-treated asthmatic patients

Nicolaescu, Vlad; Racoveanu, C; Manicatide, M

doi:10.1007/bf00561793

Cited by 11 publications

(7 citation statements)

References 21 publications

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“…They have involved intravenous and oral routes of administration, measurements of FEVy and specific airway conductance, as well as observations on histamine-or acetylcholine-induced bronchoconstriction. Such studies have shown little agreement and a wide variation in the individual response to these drugs (Zaid and Beall, 1966;MacDonald et al, 1967;Marcelle et al, 1968;Richardson and Sterling, 1969;Tumer et ad., 1971;Nicolaescu et al, 1973;Ziskind et al, 1973;Kumana and Kaye, 1974). Hence there was a need for a more sensitive method of assessing effects on airway resistance.…”

Section: Discussionmentioning

confidence: 99%

New Approach to Assessment of Cardioselectivity of Beta-blocking Drugs

Kumana¹,

Marlin²,

Kaye³

et al. 1974

BMJ

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Small though significant differences (P < 0-05) were found only between the changes in FEVy after placebo and the reductions after each drug at one, two, and three hours, and there was no significant difference beween the effects of the two drugs. This study supported the suggestion that betasympathetic stimulation contributes to the bronchodilatation evident during exercise. Moreover, it emphasizes the importance of assessing airway resistance both at rest and during exercise and of comparing the pulmonary effects of different drugs when their cardiac beta-blocking activity is equivalent.

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Section: Discussionmentioning

confidence: 99%

New Approach to Assessment of Cardioselectivity of Beta-blocking Drugs

Kumana¹,

Marlin²,

Kaye³

et al. 1974

BMJ

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“…The step test is widely used in healthy subjects, and several step test protocols have been adapted to study various outcomes in cardiopulmonary diseases. [3][4][5][6][7][8][9][10][11][12][13] The advantage of the step test over the 6-min walk test or shuttle test is that the step test requires less space and therefore can be conducted in settings such as an intensive care unit, a physician's office, or at a home-based or inpatient rehabilitation program.…”

Section: Introductionmentioning

confidence: 99%

Chester Step Test in Patients With COPD: Reliability and Correlation With Pulmonary Function Test Results

et al. 2011

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BACKGROUND:The 5-stage Chester step test assesses aerobic capacity in healthy subjects. It has not been tested in patients with COPD. OBJECTIVE: To determine the reliability of the Chester step test in patients with COPD and correlation with pulmonary function test and exercise test results. METHODS: Thirty-two patients (mean ؎ SD FEV 1 46 ؎ 15% of predicted) undertook 2 Chester step tests and two 6-min walk tests, on different days, in random order. A subgroup of 11 patients performed incremental cycle ergometry. RESULTS: Thirty-one patients performed stage 1 of the Chester step test. Nineteen patients performed stage 2 of the Chester step test. The number of steps was highly reproducible: 66 ؎ 41 steps vs 68 ؎ 41 steps. There was no difference in heart rate or S pO 2 between the 2 Chester step tests at the peak of exercise or at the end of each stage. There was a significant correlation between number of steps and FEV 1 (r ‫؍‬ 0.43, P ‫؍‬ .02), and 6-min walk distance (r ‫؍‬ 0.60, P ‫؍‬ .001). Heart rate increased according to advanced stages of the Chester step test, up to 81 ؎ 13% of predicted. There was a significant correlation between number of steps and peak heart rate (r ‫؍‬ 0.55, P ‫؍‬ .001). In the 11 patients who performed the incremental cycling test there was a significant correlation between number of steps and peak work load (r ‫؍‬ 0.69, P ‫؍‬ .02). In the 6 patients in whom oxygen uptake could be estimated from the Chester step test, oxygen uptake was higher than that measured at the peak of the cycling test (30.8 ؎ 5.1 mL/kg/min vs 17.4 ؎ 4.5 mL/kg/min, respectively, P ‫؍‬ .001). CONCLUSIONS: Despite being highly reproducible, the Chester step test had a very short duration in patients with COPD. The number of steps incremented in each stage seems to be too large for these patients. An adaptation of the Chester step test should be considered for patients with COPD.

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“…In the first study to use a step test in individuals with asthma, the Master two-step test was employed as a way to induce bronchospasm for estimating the effects that treatment with a beta-blocker (practolol, one 50-mg tablet four times a day for three days) has on the response to exercise in a group of adult asthma patients (38-54 years of age). (21) The step test did not induce bronchoconstriction, leading to stages, each lasting 3 min, at stepping rates of 17, 26, and 34 steps/min.…”

Section: Asthmamentioning

confidence: 92%

“…The initial stepping rate is 10 steps/min, increasing by 1 step/min every 30 s, until patient tolerance has been reached. Data from a pilot (21) Asthma (10) 23 a 1.5 SP Young et al (22) Asthma (32) 15-20 b -5.0 SP Feinstein et al (23) Asthma (548) 15-20 b -5.0 SP Feinstein et al (24) Asthma (48) 15-20 b -5.0 SP Tancredi et al (25) Asthma (154) 30 30 3.0 EP Balfour-Lynn et al (26) CF (54) 15 30 3.0 EP Aurora et al (27) CF (28) 15 30 3.0 EP Narang et al (28) CF (19) 15 30 3.0 EP Dal Corso et al (29) IPF (31) 20 -6.0 SP Stephan et al (30) IPF (59) 20 -4.0 SP Rusanov et al (31) IPF (51) 20 [15] a SP Shirit et al (32) IPF (51) 20 [15] a SP Swinburn et al (33) COPD (17) 25 15 10.0 EP Kramer et al (34) COPD (96) 25 [15] a SP Starobin et al (35) COPD (50) 20 [15] a SP de Camargo et al (40) COPD (32) 20 15 with a 5-step increase every 2 min 10.0 EP Dal Corso et al (41) COPD (…”

Section: Idiopathic Pulmonary Fibrosismentioning

confidence: 99%

O uso de testes do degrau para a avaliação da capacidade de exercício em pacientes com doenças pulmonares crônicas

et al. 2012

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Step tests are typically used to assess exercise capacity. Given the diversity of step tests, the aim of this review was to describe the protocols that have been used in healthy subjects and in patients with chronic lung disease. Step tests for use in healthy subjects have undergone a number of modifications over the years. In most step tests, the duration is variable (90 s-10 min), but the step height (23.0-50.8 cm) and stepping rate (22.5-35.0 steps/min) remain constant throughout the test. However, the use of a fixed step height and constant stepping rate might not provide adequate work intensity for subjects with different levels of fitness, the workload therefore being above or below individual capacity. Consequently, step test protocols have been modified by introducing changes in step heights and stepping rates during the test. Step tests have been used in patients with chronic lung diseases since the late 1970s. The protocols are quite varied, with adjustments in step height (15-30 cm), pacing (self-paced or externally paced), and test duration (90 s-10 min). However, the diversity of step test protocols and the variety of outcomes studied preclude the determination of the best protocol for use in individuals with chronic lung disease. Shorter protocols with a high stepping rate would seem to be more appropriate for assessing exercise-related oxygen desaturation in chronic lung disease. Symptom-limited testing would be more appropriate for evaluating exercise tolerance. There is a need for studies comparing different step test protocols, in terms of their reliability, validity, and ability to quantify responses to interventions, especially in individuals with lung disease.

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Effects of exercise on practolol-treated asthmatic patients

Cited by 11 publications

References 21 publications

New Approach to Assessment of Cardioselectivity of Beta-blocking Drugs

New Approach to Assessment of Cardioselectivity of Beta-blocking Drugs

Chester Step Test in Patients With COPD: Reliability and Correlation With Pulmonary Function Test Results

O uso de testes do degrau para a avaliação da capacidade de exercício em pacientes com doenças pulmonares crônicas

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