Effects of exercise on muscle mass, strength, and physical performance in older adults with sarcopenia: A systematic review and meta-analysis according to the EWGSOP criteria

Escriche-Escuder, Adrián; Fuentes-Abolafio, Iván José; Roldán-Jiménez, Cristina; Cuesta-Vargas, Antonio

doi:10.1016/j.exger.2021.111420

Cited by 37 publications

(16 citation statements)

References 54 publications

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“…Conversely, exercise training is well characterized as an important contributor to muscle mass and strength and is considered to have a therapeutic effect on age-related sarcopenia. Recent systemic reviews and meta-analyses have found that exercise training has positive effects on muscle strength and physical performance in older adults ( Bao et al, 2020 ; Escriche-Escuder et al, 2021 ; Wu et al, 2020 ). Furthermore, Chen et al (2017) demonstrated that aerobic, resistance, and combined exercise training improved skeletal muscle mass in the elderly populations with sarcopenic obesity after training interventions.…”

Section: Effects Of Exercise On the Skeletal Muscle In Estrogen Defic...mentioning

confidence: 99%

Role of exercise in estrogen deficiency-induced sarcopenia

Cho¹,

Choi²,

Jung³

et al. 2022

J Exerc Rehabil

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A decline in estrogen levels during menopause is associated with the loss of muscle mass and function, and it can accelerate sarcopenia. However, with the growing number of postmenopausal women due to the increase in life expectancy, the effects of estrogen on skeletal muscle are not completely understood. This article reviews the relationship between estrogen deficiency and skeletal muscle, its potential mechanisms, including those involving mitochondria, and the effects of exercise on estrogen deficiency-induced skeletal muscle impairment. In particular, mitochondrial dysfunction induced by estrogen deficiency accelerates sarcopenia via mitochondrial dynamics, mitophagy, and mitochondrial-mediated apoptosis. It is well known that exercise training is essential for health, including for the improvement of sarcopenia. This review highlights the importance of exercise training (aerobic and resistance exercise) as a therapeutic intervention against estrogen deficiency-induced sarcopenia.

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Section: Effects Of Exercise On the Skeletal Muscle In Estrogen Defic...mentioning

confidence: 99%

Role of exercise in estrogen deficiency-induced sarcopenia

Cho¹,

Choi²,

Jung³

et al. 2022

J Exerc Rehabil

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“…It should be pointed out that the authors observed, as anticipated, a huge heterogeneity in the exercise programs which ranged from 30 to 80 min of training, 1 to 5 training sessions weekly during 6 to 36 weeks. Another very recent meta-analysis, published in 2021, including adults older than 60 years suffering from sarcopenia diagnosed with the EWGSOP criteria, included 7 clinical trials [16]. The authors confirmed the importance of exercise on physical performance (with a standardized mean difference of 1.21, 95%CI [0.79 to 1.62]) and on muscle strength (0.51, 95%CI [0.25 to 0.76]).…”

Section: Intervention Studiesmentioning

confidence: 90%

Lifestyle approaches to prevent and retard sarcopenia: A narrative review

2022

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“…For example, physical exercise interventions could be suggested in people with sarcopenia and without symptomatic knee OA since this kind of intervention is able to prevent further muscle mass loss ( 42 ), incident knee OA (in particular forms associated to pain) ( 43 ), and pain itself ( 44 ). In this regard, it should be acknowledged that muscle strengthening exercises can improve physical performance and muscle strength parameters in people affected by sarcopenia ( 45 ), having the potential to probably prevent symptomatic knee OA.…”

Section: Discussionmentioning

confidence: 99%

Lower Limb Muscle Strength and Muscle Mass Are Associated With Incident Symptomatic Knee Osteoarthritis: A Longitudinal Cohort Study

et al. 2021

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Recent literature suggests that sarcopenia, often represented by low lower limbs muscle mass and strength, can be considered a potential risk factor for knee osteoarthritis (OA), but the available literature is still limited. We therefore aimed to investigate whether sarcopenia is associated with a higher risk of radiographic (ROA) and symptomatic knee OA (SxOA) in a large cohort of North American people in the context of the OA initiative. Sarcopenia at baseline was diagnosed in case of low skeletal muscle mass (i.e., lower skeletal mass index) and poor performance in the chair stands test. The outcomes of interest for this study included ROA (radiographical osteoarthritis) if a knee developed a Kellgren and Lawrence (KL) grade ≥2 at follow-up, and SxOA (symptomatic osteoarthritis) defined as new onset of a combination of painful knee OA. Altogether, 2,492 older participants (mean age: 68.4 years, 61.4% females) were included. At baseline, sarcopenia was present in 6.1% of the population. No significant difference in ROA prevalence was observed between those with and without sarcopenia (p=0.76), whilst people with sarcopenia reported a significant higher prevalence of SxOA (p<0.0001). Using a logistic regression analysis, adjusting for potential confounders at baseline and the diagnosis of sarcopenia during follow-up, sarcopenia was associated with a higher incidence of knee SxOA (odds ratio, OR=2.29; 95%CI [confidence interval]: 1.42-3.71; p=0.001), but not knee ROA (OR=1.48; 95%CI: 0.53-4.10; p=0.45). In conclusion, sarcopenia could be associated with a higher risk of negative knee OA outcomes, in particular symptomatic forms.

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Effects of exercise on muscle mass, strength, and physical performance in older adults with sarcopenia: A systematic review and meta-analysis according to the EWGSOP criteria

Cited by 37 publications

References 54 publications

Role of exercise in estrogen deficiency-induced sarcopenia

Role of exercise in estrogen deficiency-induced sarcopenia

Lifestyle approaches to prevent and retard sarcopenia: A narrative review

Lower Limb Muscle Strength and Muscle Mass Are Associated With Incident Symptomatic Knee Osteoarthritis: A Longitudinal Cohort Study

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