Effects of exercise on knee joints with osteoarthritis: A pilot study of biologic markers

Bautch, Judith C.; Malone, Daniel G.; Vailas, A. C.

doi:10.1002/art.1790100108

Cited by 74 publications

(69 citation statements)

References 33 publications

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“…The intervention concerned an 8-week supervised group therapy that mainly consisted of "fitness walking" (47). The other studies concerned patients with knee OA according to the criteria of the American College of Rheumatology who were recruited from both the community and the clinic (8), and patients with knee OA (not specified) who were recruited in the clinic (12). The exercise interventions consisted of a 12-week walking program (8) or an 8-week strength training program monitored on a dynamometer (12).…”

Section: Van Baar Et Almentioning

confidence: 99%

“…Among the 3 trials with low validity and low power (8,12,47), the lower limit of the 95% CI exceeded 0.2 in 1 of them (47). This study concerned patients with knee OA for a mean duration of Ͼ10 years, and participants were recruited from the community and the clinic.…”

Section: Van Baar Et Almentioning

confidence: 99%

“…Consequently, 12 publications concerning 10 trials were included in our systematic review (8)(9)(10)(11)(12)(45)(46)(47)(48)(49)(50)(51) 48). In addition, 1 report that had been accepted for publication was included (52).…”

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Effectiveness of exercise therapy in patients with osteoarthritis of the hip or knee: A systematic review of randomized clinical trials

Baar

Assendelft

Dekker

et al. 1999

Arthritis & Rheumatism

476

379

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Objective. To review the effectiveness of exercise therapy in patients with osteoarthritis (OA) of the hip or knee.Methods. A computerized literature search of Medline, Embase, and Cinahl was carried out. Randomized clinical trials on exercise therapy for OA of the hip or knee were selected if treatment had been randomly allocated and if pain, self-reported disability, observed disability, or patient's global assessment of effect had been used as outcome measures. The validity of trials was systematically assessed by independent reviewers. Effect sizes and power estimates were calculated. A best evidence synthesis was conducted, weighting the studies with respect to their validity and power.Results. Six of the 11 assessed trials satisfied at least 50% of the validity criteria. Two trials had sufficient power to detect medium-sized effects. Effect sizes indicated small-to-moderate beneficial effects of exercise therapy on pain, small beneficial effects on both disability outcome measures, and moderate-to-great beneficial effects according to patient's global assessment of effect. Conclusion.There is evidence of beneficial effects of exercise therapy in patients with OA of the hip or knee. However, the small number of good studies restricts drawing firm conclusions.Osteoarthritis (OA) is a relatively common musculoskeletal disorder. A population-based incidence study from the US showed incident rates of 0.5/1,000 per year for hip OA (presented for medical consultation) and 2/1,000 per year for knee OA (1). Prevalence increases with age (2,3). In recent treatment guidelines for OA of the hip and knee (4,5), exercise therapy is considered to be an important nonpharmacologic treatment approach. The goal of exercise therapy in OA patients is to reduce pain and disability. In order to achieve this, exercise therapy aims at the improvement of muscle strength, stability of joints, range of motion, and aerobic fitness. These functions are frequently impaired in patients with OA, presumably contributing to pain and disability (6). Improving these functions is assumed to result in a reduction of pain and disability. In addition, exercise therapy aims directly at reduction of disability, e.g., through corrections of the walking pattern (7).Since the publication of the treatment guidelines mentioned above, several new randomized clinical trials (RCTs) on exercise therapy in OA patients have been published (8-12). These newly published RCTs were not included in previous reviews (7,(13)(14)(15)(16)(17)(18)(19). Furthermore, the methodology for reviews of the literature has evolved considerably (20)(21)(22). Current methodology requires several explicit and systematic steps to be made in conducting reviews of the literature. These steps are a systematic search of the literature (23), selection of studies based on explicit inclusion and exclusion criteria (24), assessment of methodologic quality (25), and a

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Section: Van Baar Et Almentioning

confidence: 99%

Section: Van Baar Et Almentioning

confidence: 99%

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Effectiveness of exercise therapy in patients with osteoarthritis of the hip or knee: A systematic review of randomized clinical trials

Baar

Assendelft

Dekker

et al. 1999

Arthritis & Rheumatism

476

379

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“…85 Ettinger (1997) 86 van Baar (1998) 87 Maurer (1999) 88 O'Reilly (1999) 89 Péloquin (1999) 90 Deyle (2000) 91 Hopman-Rock (2000) 92 Baker (2001) 93 Fransen (2001) 94 Halbert (2001) 95 Patrick (2001) 96 Belza (2002) 97 Thomas (2002) 98 Topp (2002) 99 Foley (2003) 100 Quilty (2003) 101 Talbot (2003) 102 Hughes (2004) 103 Keefe (2004) 104 Lin (2004) 105 Messier (2004) 106 Ravaud (2004) 107 Bennell (2005) 108 Cochrane (2005) 109 Tak (2005) 110 Hay (2006) 34 Mikesky (2006) 111 Fransen (2007) 112 Hinman (2007) 113 Wang (2007) 114 Subtotal (I 2 = 0.0%; p = 0.990) Sensitivity analyses were performed for advice and information, and exercise intervention studies, with results showing minimal differences in the pooled effect estimates after exclusion of studies with a high risk of bias.…”

Section: Clinical Effectiveness Of Primary Care Interventions For Ostmentioning

confidence: 99%

Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials

Hay

Dziedzic

Foster

et al. 2018

Programme Grants Appl Res

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This report should be referenced as follows:Hay E, Dziedzic K, Foster N, Peat G, van der Windt D, Bartlam B, et al. Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials. Programme Grants Appl Res 2018;6(4). Programme Grants for Applied ResearchISSN 2050-4322 (Print) ISSN 2050-4330 (Online) This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: journals.library@nihr.ac.ukThe full PGfAR archive is freely available to view online at www.journalslibrary.nihr.ac.uk/pgfar. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Programme Grants for Applied Research journalReports are published in Programme Grants for Applied Research (PGfAR) if (1) they have resulted from work for the PGfAR programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors. Programme Grants for Applied Research programmeThe Programme Grants for Applied Research (PGfAR) programme, part of the National Institute for Health Research (NIHR), was set up in 2006 to produce independent research findings that will have practical application for the benefit of patients and the NHS in the relatively near future. The Programme is managed by the NIHR Central Commissioning Facility (CCF) with strategic input from the Programme Director.The programme is a national response mode funding scheme that aims to provide evidence to improve health outcomes in England through promotion of health, prevention of ill health, and optimal disease management (including safety and quality), with particular emphasis on conditions causing significant disease burden.For more information about the PGfAR programme please visit the website: http://www.nihr.ac.uk/funding/programme-grants-forapplied-research.htm This reportThe research reported in this issue of the journal was funded by PGfAR as project number RP-PG-0407-10386. The contractual start date was in July 2008. The final report began editorial review in March 2015 and was accepted for publication in May 2016. As the funder, the PGfAR programme agreed the research questions and study designs in advance with the investigators. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The PGfAR editors and production house have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the final report document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publicatio...

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“…The intervention concerned an 8-week supervised group treatment that mainly consisted of "fitness walking." Other studies examined patients with knee osteoarthritis according to the criteria of the American College of Rheumatology, who were recruited from both the community and the clinic, 15 and patients with knee osteoarthritis (not specified), who were recruited in the clinic, 13 and included exercise interventions consisting of a 12-week walking program 15 or an 8-week strength training program monitored on a dynamometer. 13 Thus, the evidence indicates a small to moderate beneficial effect of exercise treatment on pain in knee osteoarthritis.…”

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confidence: 99%

Is exercise effective treatment of osteoarthritis of the knee?

Petrella

2001

Western Journal of Medicine

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Effects of exercise on knee joints with osteoarthritis: A pilot study of biologic markers

Abstract: Objective. To determine the effects of low intensify weight-bearing exercise on osteoarthntis [OA)

Cited by 74 publications

References 33 publications

Effectiveness of exercise therapy in patients with osteoarthritis of the hip or knee: A systematic review of randomized clinical trials

Effectiveness of exercise therapy in patients with osteoarthritis of the hip or knee: A systematic review of randomized clinical trials

Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials

Is exercise effective treatment of osteoarthritis of the knee?

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