Effects of Exercise on Insulin Resistance and Body Composition in Overweight and Obese Women with and without Polycystic Ovary Syndrome

Hutchison, Samantha; Stepto, Nigel K.; Harrison, Cheryce L.; Moran, Lisa J.; Strauss, Boyd Josef Gimnicher; Teede, Helena

doi:10.1210/endo.151.11.9994

Cited by 52 publications

(117 citation statements)

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“…Although in those subjects who lost weight, the reduction in visceral fat was 35%. A recent study in 20 young women with PCOS using a single slice multislice CT scan also observed a 10% reduction in visceral fat after 3 months of aerobic training (12) indicating that lack of significance in the current report is likely due to our small sample size. Future studies should explore further the importance of visceral fat in reproductive function in PCOS.…”

contrasting

confidence: 72%

Aerobic exercise in women with polycystic ovary syndrome improves ovarian morphology independent of changes in body composition

Redman

Elkind‐Hirsch

Ravussin

2011

Fertility and Sterility

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In a prospective study, 8 women with polycystic ovary syndrome completed 16 weeks of individualized aerobic exercise training. Independent of changes in body weight and adiposity there was a significant increase in aerobic fitness and insulin sensitivity and a significant decrease in the total number of follicles measured by magnetic resonance imaging.Recently and based initially on studies in obesity and type 2 diabetes, lifestyle modification has been adopted as the first line of treatment to manage both the reproductive and metabolic dysfunctions in overweight and obese women with PCOS (1-3). As a result a surge in clinical studies involving dietary restriction alone (4-7) or in combination with physical activity programs have been conducted (8,9). Collectively these studies indicate that a reduction in body weight of at least 5% leads to significant improvements in menstrual cyclicity, ovulation and biochemical hyperandrogenism in terms of the reproductive complaints (4,6-9) and improved glucose tolerance and reduced risk for cardiovascular disease (4,8). One intriguing finding was that in comparison to dietary restriction (800 kcal/ d), aerobic exercise led to a 40% higher rate of ovulation (25% versus 65%, respectively) and greater improvements in SHBG and testosterone despite less weight loss (10). Aerobic exercise resulted in a greater reduction in fasting insulin and insulin resistance (HOMA-IR) suggesting a possible mechanistic link. Exercise-induced changes in visceral fat and ectopic lipid in non-fatty tissues are probably important components however to our knowledge only one recent study using single slice computed tomography measured changes in visceral fat with exercise training in PCOS (11). Studies using magnetic resonance imaging or spectroscopy are seldom no studies have yet quantified the effects of exercise on the polycystic ovarian morphology.As detailed previously (13), eight young (18-30 years), overweight/obese (BMI ≥25 kg/m 2 ) women with PCOS completed a 16-week study of aerobic exercise. Seven normally cycling controls (BMI ≥25 kg/m 2 ) were also enrolled to complete baseline testing only. The Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. All exercise training was performed under supervision at the PBRC Fitness Center five times per week. Exercise was prescribed on an individual basis with the objective to achieve specified exercise energy expenditure (ExEE) per day as previously described (13). Diet was not controlled throughout the exercise intervention however a standardized eucaloric diet (35% fat, 15% protein, 50% carbohydrate) ...

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contrasting

confidence: 72%

Aerobic exercise in women with polycystic ovary syndrome improves ovarian morphology independent of changes in body composition

Redman

Elkind‐Hirsch

Ravussin

2011

Fertility and Sterility

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“…16 It seems that the lifestyle changes that combine reducing food intake for weight loss and regular exercise are a preferred treatment strategy in overweight and obese women with PCOS. 17 Despite the known benefits of a healthy lifestyle, it was interesting to note that a relatively large number of girls with PCOS and controls were not aware of the positive effects of exercise on health, which supports our hypothesis that adolescents and their parents do not have sufficient information about the benefits of physical activity, particularly, in relation to the symptomatology of PCOS.…”

Section: Discussionmentioning

confidence: 99%

Exercise and Sedentary Habits Among Adolescents with PCOS

Eleftheriadou

Michala

Stefanidis

et al. 2012

Journal of Pediatric and Adolescent Gynecology

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“…A ramp protocol, adapted from previous studies involving women with PCOS [5,6] was used. The VO 2max was determined by the presence of at least one of the following criteria: (i) respiratory exchange ratio (VCO 2 /VO 2 )41.1; (ii) occurrence of plateau in oxygen uptake; (iii) physical volitional exhaustion [29].…”

Section: Cardiopulmonary Exercise Testmentioning

confidence: 99%

“…Exercise is a crucial component of lifestyle intervention by promoting several benefits on body composition [2][3][4][5], cardiovascular [2][3][4]6], metabolic [3,[5][6][7][8], reproductive [9][10][11][12] and psychological [13,14] health of women with PCOS. However, the long-term adherence to exercise is a challenge [15].…”

Section: Introductionmentioning

confidence: 99%

Affect-regulated exercise: an alternative approach for lifestyle modification in overweight/obese women with polycystic ovary syndrome

Costa¹,

Sá²,

Costa³

et al. 2015

Gynecological Endocrinology

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Effects of Exercise on Insulin Resistance and Body Composition in Overweight and Obese Women with and without Polycystic Ovary Syndrome

Abstract: J Clin Endocrinol Metab, published October 6, 2010, 10.1210/jc.2010-0828

Cited by 52 publications

References 0 publications

Aerobic exercise in women with polycystic ovary syndrome improves ovarian morphology independent of changes in body composition

Aerobic exercise in women with polycystic ovary syndrome improves ovarian morphology independent of changes in body composition

Exercise and Sedentary Habits Among Adolescents with PCOS

Affect-regulated exercise: an alternative approach for lifestyle modification in overweight/obese women with polycystic ovary syndrome

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