Effects of exercise on circulating vascular adhesion molecules in healthy men

Jilma, Bernd; Eichler, Hans‐Georg; Stohlawetz, Petra; Dirnberger, Eva; Kapiotis, Stylianos; Wagner, Oswald; Schütz, Wolfgang; Krejcy, Kurt

doi:10.1016/s0171-2985(97)80082-4

Cited by 41 publications

(33 citation statements)

References 26 publications

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“…Rather, wellknown relationships between exercise and endothelial function are probably related to slow-progressing time-dependent mechanisms. These results agree with other data suggesting lack of 28 or minor 29 influence of aerobic performance on adhesion molecules after exercise from small to moderate intensity in healthy subjects. Postexercise CRP levels increased, in agreement with the results obtained after a less strenuous exercise, 30 whereas leptin levels fell.…”

Section: Discussionsupporting

confidence: 93%

Strikingly Low Circulating CRP Concentrations in Ultramarathon Runners Independent of Markers of Adiposity

Tomaszewski

Charchar

Przybycin

et al. 2003

ATVB

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Objective-This study was undertaken to evaluate to what extent C-reactive protein (CRP) can be reduced by exercise by examining its circulating concentrations in male ultramarathon runners and to determine if low leptin as a robust circulating marker of fat mass could account for low CRP in such men. Methods and Results-Sixty-seven male ultramarathon runners and 63 sedentary male controls of similar age and body mass index were recruited. CRP and leptin were measured by ELISA and radioimmunoassay, respectively. Median CRP concentration in lean (body mass index Ͻ25 kg/m 2 ) marathon runners was less than half control median (0. Circulating leptin levels were also substantially lower in lean (45% less) and nonlean (63% less, both PϽ0.0001) ultramarathon runners. However, interleukin-6 levels were not different. Furthermore, leptin adjustment only minimally attenuated the case-control difference in CRP, suggesting that mechanisms other than fat mass reduction contribute to low concentrations of CRP in marathon runners. Conclusions-This

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Section: Discussionsupporting

confidence: 93%

Strikingly Low Circulating CRP Concentrations in Ultramarathon Runners Independent of Markers of Adiposity

Tomaszewski

Charchar

Przybycin

et al. 2003

ATVB

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“…This result is consistent with previous studies showing that vasoconstrictor such as epinephrine has no influence on adhesion molecule expression 23 . On the other hand, some studies suggested that adrenergic stress results in compartmental redistribution of T-lymphocytes in vivo 24 .…”

Section: Fig 2 Surface Membrane Expression Of CD 62l (L Selectin)supporting

confidence: 94%

Stress regulates the lymphocyte homing receptor CD62L (L-selectin)

Manfro

Netto

Pollack

et al. 2003

Arq. Neuro-Psiquiatr.

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-Based on a previous study showing that panic disorder patients had increased expression of naïve phenotype lymphocytes (CD45RA+ and CD62L+), increased plasma cortisol, as well as decreased interleukin-2 (IL-2) producion, we hypothesized that changes in the percentage of expression of these lymphocyte surface molecules could be related to the substances released by the hypothalamic-pituitary-adrenal (HPA) axis and possibly associated to panic disorder (cortisol, IL-2, serotonin and epinephrine). In order to study the altered expression, blood mononuclear cells of normal volunteers were stimulated with mitogen, in the presence of dexamethasone, IL-2, serotonin and epinephrin. CD62L is decreased by IL-2 in vitro. Serotonin and epinephrine did not promote changes in the expression of these surface molecules. The results of the ex vivo study are in agreement with a previous clinical study with panic patients. It could be suggested that stress is responsible for certain immunologic dysfunctions and new studies should be conducted.KEY WORDS: corticosteroids, interleukin-2, lymphocyte migration, adhesion molecules, panic disorder.Regulação do receptor de alojamento linfocitário CD62L (L Regulação do receptor de alojamento linfocitário CD62L (L Regulação do receptor de alojamento linfocitário CD62L (L Regulação do receptor de alojamento linfocitário CD62L (L Regulação do receptor de alojamento linfocitário CD62L (L-selectina) pelo estresse -selectina) pelo estresse -selectina) pelo estresse -selectina) pelo estresse -selectina) pelo estresse RESUMO -Baseado em estudo prévio que demonstrou que os pacientes com transtorno do pânico apresentavam aumento na porcentagem de expressão de linfócitos com fenótipo virgem (CD45RA+ e CD62L+), aumento no cortisol plasmático, assim como diminuição na produção de interleucinas, foi sugerido que as alterações na porcentagem de expressão dessas moléculas de superfície dos linfócitos poderia estar relacionada com a liberação de substâncias pelo eixo hipotálamo-hipófise-adrenal (HHA) e possivelmente associada ao transtorno do pânico (cortisol, IL-2, serotonina e epinefrina). Com o objetivo de estudar essas alterações, células mononucleares do sangue periférico de voluntários normais foram estimuladas com mitógeno, na presença de dexametasona, IL-2, serotonina e epinefrina. A expressão de CD62L "in vitro" é diminuida com IL-2. Serotonina e epinefrina não promovem alterações na expressão dessas moléculas de superfície. Os resultados desse estudo "in vitro" estão de acordo com o estudo clínico prévio com pacientes com transtorno do pânico. Podese sugerir que o estresse é responsável por algumas disfunções imunológicas e novos estudos devem ser delineados para testar essa hipótese.PALAVRAS-CHAVE: corticosteróides, interleucina-2, migração linfocitária, moléculas de adesão, transtorno do pânico.

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“…30 The observation in the current study, that men who exercise regularly are more likely to have lower sICAM-1 levels, is consistent with the known beneficial effects of regular physical activity.…”

Section: Rohde Et Al Sicam-1 and Cardiovascular Risk Factorssupporting

confidence: 89%

Cross-Sectional Study of Soluble Intercellular Adhesion Molecule-1 and Cardiovascular Risk Factors in Apparently Healthy Men

Rohde

Hennekens

Ridker

1999

ATVB

147

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Abstract-An elevated plasma concentration of the soluble intercellular adhesion molecule-1 (sICAM-1) is associated with increased risk for future coronary events. However, data exploring the interrelations of sICAM-1 with known cardiovascular risk factors are sparse. We determined sICAM-1 levels in 948 middle-aged men with no prior history of cardiovascular disease. sICAM-1 levels increased with age (PϽ0.001) and were significantly associated with smoking (PϽ0. Key Words: adhesion molecules Ⅲ inflammation Ⅲ risk factors Ⅲ atherosclerosis C ellular adhesion molecules mediate the attachment and transmigration of leukocytes across the endothelial surface, and are hypothesized to play an important role in the initiation of atherosclerosis. 1 Focal expression of adhesion molecules has been demonstrated in atherosclerotic lesions, 2-4 precedes leukocyte infiltration, 5,6 and seems to be mediated in part by modified lipoproteins or their constituents. 7 Several small studies have demonstrated that plasma concentrations of soluble intercellular adhesion molecule-1 (sICAM-1) are elevated in atherosclerotic syndromes, 8 -12 and 2 recent prospective studies indicate that elevated baseline levels of sICAM-1 are associated with increased risk for future coronary events. 11,13 However, despite these provocative data, little is known about potential relations between circulating adhesion molecules and established cardiovascular risk factors.We explored potential associations between the soluble adhesion molecule sICAM-1 and a series of lipid and nonlipid cardiovascular risk factors among 948 apparently healthy men participating in the Physicians' Health Study. Specifically, we evaluated for evidence of association between sICAM-1 levels and age, smoking status, blood pressure, alcohol use, exercise frequency, body mass index, total cholesterol, HDL cholesterol (HDL-C), triglycerides, Lp(a), fibrinogen, tissue-type plasminogen activator antigen, and total homocysteine levels. MethodsWe evaluated sICAM-1 levels in a cross-section of apparently healthy middle-aged men participating in the Physician's Health Study. In brief, the Physician's Health Study was a randomized, double-blind, placebocontrolled 2ϫ2 factorial design trial of aspirin and ␤-carotene among US male physicians aged 40 to 84 years. 14 Exclusion criteria included a history of myocardial infarction, stroke, or transient ischemic attack; cancer; current renal or liver disease; peptic ulcer or gout; contraindication to aspirin consumption; current use of aspirin, other plateletactive drugs, or nonsteroidal anti-inflammatory agents; and current use of vitamin A or ␤-carotene supplement.As described elsewhere, 13 eligible participants were asked to provide baseline blood plasma samples. Kits including edetic acid tubes and plastic collection vials were sent to each doctor along with instructions for blood drawing. Participants were asked to have their blood drawn and centrifuged, and have the plasma returned (accompanied by a cold pack) by overnight courier. Participa...

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Effects of exercise on circulating vascular adhesion molecules in healthy men

Cited by 41 publications

References 26 publications

Strikingly Low Circulating CRP Concentrations in Ultramarathon Runners Independent of Markers of Adiposity

Strikingly Low Circulating CRP Concentrations in Ultramarathon Runners Independent of Markers of Adiposity

Stress regulates the lymphocyte homing receptor CD62L (L-selectin)

Cross-Sectional Study of Soluble Intercellular Adhesion Molecule-1 and Cardiovascular Risk Factors in Apparently Healthy Men

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