Effects of exercise on cardiac weight and mitochondria in male and female rats

Lb, Oscai; Mole, P. A.; Holloszy, J. O.

doi:10.1152/ajplegacy.1971.220.6.1944

Cited by 146 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study found that exercise had no effect on the body weight of either sex. Previous studies have found that chronic forced exercise decreases body weight [57-59]; however, in these studies exercise was more strenuous (2–6 h per day of forced swimming) than what rats were exposed to in our study.…”

Section: Discussioncontrasting

confidence: 66%

Chronic forced exercise during adolescence decreases cocaine conditioned place preference in Lewis rats

Thanos

Tucci

Stamos

et al. 2010

Behavioural Brain Research

View full text Add to dashboard Cite

Chronic physical activity (exercise) may be beneficial in the prevention of substance use disorders; however, the extent to which physical activity can interfere with the reinforcing effects of drugs during the adolescent period, which is one of great vulnerability for drug experimentation, has not been fully evaluated. Here, we assess the effects of chronic forced exercise during adolescence on preference for cocaine using the conditioned place preference (CPP) paradigm in male and female Lewis rats. The group of rats exposed to exercise ran on a treadmill for 6 weeks on a progressive time-increased schedule for up to 1 h of exercise per day, while the groups of sedentary rats remained in their home cage. Following the 6 weeks of exercise exposure, rats were tested for cocaine CPP. Results showed that chronic exercise significantly attenuated cocaine CPP in both males and females compared to a sedentary environment. Furthermore, male exercise rats failed to show significant cocaine CPP. In contrast, female exercise rats still showed cocaine CPP but it was significantly reduced compared to the female sedentary rats. Females also exhibited greater cocaine CPP than males overall. These findings suggest that strategies to promote physical activity during adolescence may be protective against cocaine abuse in both males and females, and these findings merit further investigation. We also corroborate a gender-specific sensitivity to the reinforcing effects of cocaine, highlighting the need to consider gender-tailored exercise interventions for drug abuse prevention.

show abstract

Section: Discussioncontrasting

confidence: 66%

Chronic forced exercise during adolescence decreases cocaine conditioned place preference in Lewis rats

Thanos

Tucci

Stamos

et al. 2010

Behavioural Brain Research

View full text Add to dashboard Cite

show abstract

“…(60) Moreover, previous studies have shown that male rats undergoing a forced loading regime do not tend to compensate for the excessive energy expenditure with increased FI, unlike their female counterparts. (59) Our observations are supported by previous studies, which have reported a decreased BW simultaneous with a reduced FI in adult rats after the end of forced swimming (61) and running regimes. (55) During the normal cage activity period, the effects from the MI and HI groups on FI disappeared after 17 and 14 weeks of age, respectively (Fig.…”

Section: Cyclic Loading Temporarily Reduced Body Weight and Food Intasupporting

confidence: 89%

Isolated Cyclic Loading During Adolescence Improves Tibial Bone Microstructure and Strength at Adulthood

et al. 2020

View full text Add to dashboard Cite

Bone is a unique living tissue, which responds to the mechanical stimuli regularly imposed on it. Adolescence facilitates a favorable condition for the skeleton that enables the exercise to positively influence bone architecture and overall strength. However, it is still dubious for how long the skeletal benefits gained in adolescence is preserved at adulthood. The current study aims to use a rat model to investigate the effects of in vivo low‐ (LI), medium‐ (MI), and high‐ (HI) intensity cyclic loadings applied during puberty on longitudinal bone development, morphometry, and biomechanics during adolescence as well as at adulthood. Forty‐two young (4‐week‐old) male rats were randomized into control, sham, LI, MI, and HI groups. After a 5 day/week for 8 weeks cyclic loading regime applied on the right tibia, loaded rats underwent a subsequent 41‐week, normal cage activity period. Right tibias were removed at 52 weeks of age, and a comprehensive assessment was performed using μCT, mechanical testing, and finite element analysis. HI and MI groups exhibited reduced body weight and food intake at the end of the loading period compared with shams, but these effects disappeared afterward. HI cyclic loading increased BMD, bone volume fraction, trabecular thickness, trabecular number, and decreased trabecular spacing after loading. All loading‐induced benefits, except BMD, persisted until the end of the normal cage activity period. Moreover, HI loading induced enhanced bone area, periosteal perimeter, and moment of inertia, which remained up to the 52nd week. After the normal cage activity at adulthood, the HI group showed increased ultimate force and stress, stiffness, postyield displacement and energy, and toughness compared with the sham group. Overall, our findings suggest that even though both trabecular and cortical bone drifted through age‐related changes during aging, HI cyclic loading performed during adolescence can render lifelong benefits in bone microstructure and biomechanics. © 2020 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

show abstract

“…It has long been recognized that there is a gender dierence in the cardiac response to long-term training in rodents (Oscai et al 1971). With respect to LV adaptations, female rats, in contrast to male rats, are able to compensate for the increased energy expenditure of treadmill running by increasing their food intake, thus maintaining BW and showing an increase in absolute LV mass.…”

Section: Discussionmentioning

confidence: 99%

“…Whether long-term exercise results in hypertrophy of the right ventricle (RV) is less clear and may depend upon the mode of training (Hauser et al 1985;Sciomer et al 1998). In addition to changes in the mass of the left ventricle (LV) observed in some (Thomas et al 1992), but not all animal models of training (Burgess et al 1996;Oscai et al 1971), LV functional adaptations have also been documented that have involved changes in not only the cellular (Moore et al 1995;Stuewe et al 2000) but also the extracellular matrix (ECM; Thomas et al 1992Thomas et al , 2000. The eects of training on RV performance are also equivocal, with some studies showing enhanced capillarization and function (Anversa et al 1987;Li et al 1986) and others unable to document alterations in RV contractility (Williams and Potter 1976).…”

Section: Introductionmentioning

confidence: 99%

Exercise training attenuates aging-associated increases in collagen and collagen crosslinking of the left but not the right ventricle in the rat

Thomas

Cotter

et al. 2001

Eur J Appl Physiol

View full text Add to dashboard Cite

The purpose of this study was to compare the independent and interactive effects of age and exercise training on selected parameters of the right ventricle (RV), left ventricular septum (LVS) and left ventricular free-wall (LVFW) extracellular matrix. Specifically, we evaluated collagen and collagen crosslinking (hydroxylysylpyridinoline, HP) concentrations in the myocardial extracellular matrix in young adult, Y (5.5 months) and old, O (25.5 months) male Fischer 344 rats. Rats were assigned to either a sedentary control (YC, OC) or an exercise training group (YT, OT). Rats were trained for 45 min/day, 5 days/week, for 10 weeks at approximately equals 70% of maximal oxygen consumption. Following the training regimen, rats were sacrificed and their hearts were dissected into the RV, LVS and LVFW. Training resulted in a significant hypertrophy of the left ventricle (LV) but not RV relative to body weight. In young rats, collagen concentration was significantly higher (P<0.01) in RV compared to LVS, but not LVFW. With aging, collagen concentration increased significantly (P<0.05) in both ventricles, but more so in LV than RV so that differences in percent collagen observed between chambers in both YC and YT rats no longer existed in OC and OT animals. This aging effect was attenuated by training in the LVS but not the LVFW, so that collagen concentration, while higher in this region of the LV in OT compared to YT rats, was also lower than that seen in the LVS of OC rats. HP crosslink concentration in the LVS and LVFW, but not the RV of OC rats was significantly elevated above corresponding values seen in YC rats (P < 0.05 or greater). In YT rats, training had no effect on HP crosslinking concentration in any of the three regions of the heart. However, in OT rats, training completely prevented the age-associated increase in crosslinking seen in both the LVS and LVFW of OC animals. These findings illustrate the different responses of the RV, LVS and LVFW extracellular matrix components, collagen and HP crosslinking, to both aging and training in the rodent.

show abstract

Effects of exercise on cardiac weight and mitochondria in male and female rats

Cited by 146 publications

References 0 publications

Chronic forced exercise during adolescence decreases cocaine conditioned place preference in Lewis rats

Chronic forced exercise during adolescence decreases cocaine conditioned place preference in Lewis rats

Isolated Cyclic Loading During Adolescence Improves Tibial Bone Microstructure and Strength at Adulthood

Exercise training attenuates aging-associated increases in collagen and collagen crosslinking of the left but not the right ventricle in the rat

Contact Info

Product

Resources

About