Effects of exercise on angiogenesis and apoptosis-related molecules, quality of life, fatigue and depression in breast cancer patients

Ergün, Müge; Eyigör, Sibel; Karaca, Burçak; Kısım, Aslı; Uslu, Rüçhan

doi:10.1111/ecc.12068

Cited by 92 publications

(91 citation statements)

References 51 publications

(116 reference statements)

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“…Of the sixteen studies involving patients in active treatment [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] , six demonstrated that, compared with the control group, the intervention group experienced significant improvements in qol 30,31,33,[38][39][40]43 . In the thirteen post-treatment intervention studies 10,12,14,[45][46][47][48][49][50][51][52][53][54] , two reported similar significant differences between groups 46,49 .…”

Section: Quality Of Lifementioning

confidence: 99%

Exercise for People with Cancer: A Clinical Practice Guideline

et al. 2017

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Background Development of this guideline was undertaken by the Exercise for People with Cancer Guideline Development Group, a group organized by Cancer Care Ontario’s Program in Evidence-Based Care (pebc). The purpose of the guideline was to provide guidance for clinicians with respect to exercise for patients living with cancer, focusing on the benefits of specific types of exercise, recommendations about screening requirements for new referrals, and safety concerns.Methods Consistent with the pebc’s standardized approach, a systematic search was conducted for existing guidelines, and systematic literature searches were performed in medline and embase for both systematic reviews and primary literature. Content and methodology experts performed an internal review, which was followed by an external review by targeted experts and intended users.Results The search identified three guidelines, eighteen systematic reviews, and twenty-nine randomized controlled trials with relevance to the topic. The present guideline provides recommendations for the duration, frequency, and intensity of exercise appropriate for people living with cancer. It also provides recommendations for pre-exercise assessment, safety concerns, and delivery models.Conclusions There is sufficient evidence to show that exercise provides benefits in quality of life and muscular and aerobic fitness for people with cancer both during and after treatment, and that it does not cause harm. The present guideline is intended to support the Canadian Society for Exercise Physiology’s Canadian physical activity guidelines. The recommendations are intended for clinicians and institutions treating cancer patients in Ontario, and for policymakers and program planners involved in the delivery of exercise programs for cancer patients.

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Section: Quality Of Lifementioning

confidence: 99%

Exercise for People with Cancer: A Clinical Practice Guideline

et al. 2017

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“…Of the sixteen rcts involving patients in active treatment [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] , seven reported significant differences between the intervention and control groups (Table vi) 23,24,26,[31][32][33]36 . In the thirteen posttreatment intervention studies [38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53] , two reported significant qol improvement in the exercise groups 41,42 . In particular, patients with lymphedema experienced qol benefits, and aerobic and resistance exercises were both safe for women who had undergone breast and axillary surgery 6,7,38,39,44 .…”

Section: Qol and Muscular And Aerobic Fitnessmentioning

confidence: 99%

“…One systematic review 20 found that cardiopulmonary exercise testing was a safe, noninvasive method to measure cardiopulmonary fitness in people living with cancer, both during and after treatment. Seventeen rcts [22][23][24]27,29,[30][31][32][33]37,39,42,45,47,[51][52][53] found that no adverse events or side effects were attributable to the exercise program. Seven 26,28,34,35,40,46,50 did not report on adverse events at all.…”

Section: Commentsmentioning

confidence: 99%

Exercise for people with cancer: a systematic review

et al. 2017

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Background This systematic review was completed by the Exercise for People with Cancer Guideline Development Group, a group organized by Cancer Care Ontario’s Program in Evidence-Based Care (pebc). It provides background and guidance for clinicians with respect to exercise for people living with cancer in active and post treatment. It focuses on the benefits of specific types of exercise, pre-screening requirements for new referrals, safety concerns, and delivery models.Methods Using the pebc’s standardized approach, medline and embase were systematically searched for existing guidelines, systematic reviews, and primary literature.Results The search identified two guidelines, eighteen systematic reviews, and twenty-nine randomized controlled trials with relevance to the topic. The present review provides conclusions about the duration, frequency, and intensity of exercise appropriate for people living with cancer.Conclusions The evidence shows that exercise is safe and provides benefit in quality of life and in muscular and aerobic fitness for people with cancer both during and after treatment. The evidence is sufficient to support the promotion of exercise for adults with cancer, and some evidence supports the promotion of exercise in group or supervised settings and for a long period of time to improve quality of life and muscular and aerobic fitness. Exercise at moderate intensities could also be sustainable for longer periods and could encourage exercise to be continued over an individual’s lifetime. It is important that a pre-screening assessment be conducted to evaluate the effects of disease, treatments, and comorbidities.

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“…In this review, we have summarized a collection of various population-based studies on breast cancer and PA, and compared the beneficial effect of exercise on cancer such as the cancer type, duration, intensity, and timing of exercise (before diagnosis, after diagnosis, or during treatment) ( Table 2) [76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91][92]. Numerous studies have suggested that PA prior to breast cancer diagnosis was significantly beneficial for the patient's treatment outcome and survival [76][77][78][79][80][81][82][83][84][85][86][87][88][89][90][91][92]. For example, a group of researchers performed a prospective cohort study in Germany which included 3,393 non-metastatic breast cancer patients: the mortality of breast cancer was significantly and inversely associated with prediagnosis recreational PA [77].…”

Section: Breast Cancer and Physical Activity (Pa)mentioning

confidence: 99%

“…Some studies have investigated whether exercise can modulate circulating proinflammatory cytokines, such as IL-1β, IL-2, IL-4, macrophage inflammatory protein-1 beta (MIP-1β), and tumor necrosis factor alpha (TNF-α) [92,108,109], suggesting a protective effect of exercise on inflammation perturbation following cancer treatment. A systematic review suggests that physical exercise can lead to changes in a variety of immune system parameters, including lymphocyte function such as improved cytotoxic activity by natural killer (NK) cells and proliferation of granulocytes [110].…”

Section: Inflammatory Reactionsmentioning

confidence: 99%

Potential Mechanisms behind Physical Exercise vs. Epigenetic Regulation for Preventing Breast Cancer

Dai¹,

Yang²,

Shi³

et al. 2017

JCPCR

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Potential Mechanisms behind Physical Exercise vs. Epigenetic Regulation for Preventing Breast CancerSubmit Manuscript | http://medcraveonline.com recent years, new applications in both diagnosis and treatment have gradually reduced female breast cancer incidence rates [1]. Considering alternative prevention and therapeutic methods, physical exercise has recently been gaining increased attention in the clinic. Regular exercise appears to lower breast cancer risk by about 10-20 percent, which is a considerable impact from a non-pharmacologic intervention with no cost. Thus, the recently emerging field of exercise-oncology research will be expected to not only clarify the mechanisms behind prevention, but also shed light on future treatment for breast cancer. In this current review, we will summarize recent studies on physical exercise with respect to breast cancer, and discuss their relationship and possible underlying mechanisms. Risk factors for breast cancerBreast cancer is the second most common type of cancer and the leading cause of cancer-related death in women worldwide (link: https://www.breastfriends.org). It is a tremendous disease, affecting lifespan and healthspan. The incidence of breast cancer is increasing every year, and an estimated 252,710 new cases of invasive breast cancer are expected to be diagnosed in women in the U.S. in 2017 (link: http://www.breastcancer.org/symptoms/ understand_bc/statistics). Throughout the world, every year more than 400,000 deaths are caused by breast cancer and, out of these diagnosed cases, there are more than 2.8 million breast cancer survivors [2].Generally, there are two aspects of risk factors for breast cancer (see Table1): (1) [68][69][70]. On the other hand, due to genetic susceptibility influences, which are inherited and unchangeable; the non-modifiable factors are not easily controllable risks for breast cancer. Therefore, it is feasible to reduce the risk factors that are not inherited, but can be changed. Among these modifiable risk factors, physical exercise behaviors not only are beneficial for preventing all stages of cancer development [71], but also are helpful to maintain a healthy weight and reduce risks for developing other diseases, such as cardiovascular disease, diabetes, and stroke [72]. Furthermore, physical activity (PA) has been increasingly regarded as the nonpharmacologic intervention for many cancer patients to combat both the physiologic and psychological effects of cancer treatment [73]. A recent World Health Organization (WHO) report shows that physical inactivity remains one of the most important risk factors for total cancer related mortality (responsible for 6% of total deaths) along with overweight and obesity (responsible for another 5%) [74]. AbstractBreast cancer is the most commonly diagnosed cancer and has been the second leading cause of death due to cancer among women worldwide. It is a disease in which malignant (cancer) cells form in the tissues of the breast and become deadly when they metastasize, spreading to oth...

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Effects of exercise on angiogenesis and apoptosis-related molecules, quality of life, fatigue and depression in breast cancer patients

Cited by 92 publications

References 51 publications

Exercise for People with Cancer: A Clinical Practice Guideline

Exercise for People with Cancer: A Clinical Practice Guideline

Exercise for people with cancer: a systematic review

Potential Mechanisms behind Physical Exercise vs. Epigenetic Regulation for Preventing Breast Cancer

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