Effects of exercise interventions for physical fitness, fatigue, and quality of life in adult hematologic malignancy patients without receiving hematopoietic stem cell transplantation: a systematic review and meta-analysis

Effects of Exercise Programs on Psychoemotional and Quality-of-Life Factors in Adult Patients with Cancer and Hematopoietic Stem Cell Transplantation or Bone Marrow Transplantation: A Systematic Review

“…Moreover, it excluded studies with nutrition intervention to prevent potential intervening variable, not another systematic review [ 44 ]. Further, a recent meta-analysis in patients with hematologic cancer published in 2022, although in another clinical situation (i.e., without HSCT transplantation), observed the same lines of positive effects after an exercise intervention [ 69 ]. Therefore, the present systematic review has added to the knowledge of studies a higher methodological quality, observing improvements in specific QoL factors and in psychoemotional factors, specifically in fatigue, anxiety and depression, mood, and health.…”

“…Our data do not correspond with those of other reviews in terms of the fatigue measurement scales used: they showed no significant data on the Multidimensional Fatigue Inventory and Functional Assessment of Cancer Therapy-Bone Marrow Transplant, although they did show a decrease in the QLQ C-30 fatigue subscale [ 44 ], and showed a decrease in the QLQ C-30 fatigue subscale and did not use other fatigue measurement tools [ 45 ]. Although a variety of fatigue measurement tools, including Brief Fatigue Inventory Scale, were used, there were no significant results [ 69 ].…”

“…Therefore, exercise appears to have a healthy effect on health before and after transplantation, maintaining or even increasing the individual’s QoL. Our data showed parallels with other reviews in terms of QoL measurement: showed significant QoL improvement data on the QLQ C-30 global QoL scale [ 44 ], and showed significant QoL improvement data on the health-related quality of life, although they did not use the QLQ C-30 scale [ 45 ] and used, among others, QLQ C-30, Karnofsky Performance Status, and the 36-Item Short Form Survey, significantly increasing the quality of life in the combined exercise group [ 69 ].…”

Nonpharmacological interventions for cancer-related fatigue: A comprehensive literature review

“… 8 , 9 Exercise modalities include aerobic exercise, resistance exercise, yoga, qigong, Tai Chi, muscle relaxation training, and combination exercise. 10 Meta-analyses indicate that exercise intervention, especially combined aerobic and resistance exercise, yoga, and regular physical activity, is safe and feasible for relieving CRF 11 , 12 , 13 . Clinical guidelines also recommend exercise therapy to prevent or alleviate CRF during active and posttreatment phases.…”