Effects of Exercise Intervention on Peripheral Skeletal Muscle in Stable Patients With COPD: A Systematic Review and Meta-Analysis

Li, Peijun; Li, Jian; Wang, Yingqi; Xia, Jun; Liu, Xiaodan

doi:10.3389/fmed.2021.766841

Cited by 15 publications

(17 citation statements)

References 61 publications

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“…Consistent with previous findings on muscle strength 24 , significant heterogeneity characterizes the training programs and testing procedures of the studies included in this systematic review. Most training programs were scheduled for outpatients with COPD over two to three sessions a week for a minimum of eight weeks.…”

Section: Discussionsupporting

confidence: 83%

“…Previous reviews addressed the impact of various exercise-based interventions on different outcome measures of muscle function in persons with COPD [21][22][23][24]. However, the effects of exercise training on skeletal muscle power are yet to be explored, and a systematic review is needed to investigate the current COPD-related literature on this topic.…”

Section: Muscle Power In Patients With Chronic Obstructive Pulmonary ...mentioning

confidence: 99%

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Muscle Power in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis

et al. 2023

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This study aimed to review the impact of training on muscle power in patients with chronic obstructive pulmonary disease (COPD). Randomized controlled trials evaluating the effects of exercise-based interventions on limbs muscle power and rate of force development in COPD patients were investigated. Five international databases were searched until October 2022. Meta-analyses were performed calculating the mean difference or standardized mean difference. Risk of bias in studies was assessed using Cochrane Risk of Bias tool 2.0. A total of nine studies were included in the analysis. There were concerns about risk of bias in seven out of nine studies. Comparison of exercising and non-exercising groups showed a significant effect of exercise in improving muscle power (P=0.0004) and rate of force development (P<0.001), in five and three trials, respectively. Four studies comparing different trainings showed no significant results on muscle power (P=0.45). Eight to 16 weeks of exercise-based intervention versus no intervention might be beneficial to enhance upper and lower limbs muscle power and rate of force development in people with COPD. In contrast, muscle power did not improve when different training modalities were compared. Future studies performing power training in COPD patients are encouraged.

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Section: Discussionsupporting

confidence: 83%

Section: Muscle Power In Patients With Chronic Obstructive Pulmonary ...mentioning

confidence: 99%

Muscle Power in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis

et al. 2023

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“…Likewise, the effects of exercise training on increasing measures related to muscle or fat-free mass in COPD are inconsistent, as reported in two previous systematic reviews (18,19). Despite the prominence of nutritional supplementation and exercise training as methods to increase measures of fat-free mass in COPD, which have been the focus of previously discussed reviews, little is known about other interventions and their potential benefit.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of interventions to alter measures of fat-free mass in people with COPD: a systematic review and meta-analysis

et al. 2023

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IntroductionLow fat-free mass (FFM) is linked to poor health outcomes in COPD, including impaired exercise tolerance and premature death. The aim of this systematic review was to synthesise evidence on the effectiveness of interventions for increasing FFM in COPD.MethodsSearches of electronic databases (MEDLINE, Cochrane Library, EMBASE, Web of Science, Scopus) and trial registers (ClinicalTrials.gov) were undertaken from inception to August 2022 for randomised studies of interventions assessing measures of FFM in COPD. The primary outcome was change in FFM (including derivatives). Secondary outcomes were adverse events, compliance, and attrition.Results99 studies (n=5138 people with COPD) of 11 intervention components, used alone or in combination, were included. Exercise training increased mid-thigh cross-sectional area (k=3, SMD=1.04, 95% CI 0.02–2.06, p=0.04), but not FFM (k=4, SMD=0.03, 95% CI −0.18–0.24, p=0.75). Nutritional supplementation significantly increased FFM index (k=11, SMD=0.31, 95% CI 0.13–0.50, p<0.001), but not FFM (k=19, SMD=0.16, 95% CI −0.06–0.39, p=0.16). Combined, exercise training and nutritional supplementation increased measures related to FFM in 67% of studies. Anabolic steroids increased FFM (k=4, SMD=0.98, 95% CI 0.24–1.72, p=0.009). Neuromuscular electrical stimulation increased measures related to FFM in 50% of studies. No interventions were more at risk of serious adverse events, low compliance, or attrition.DiscussionExercise training and nutritional supplementation were not effective in isolation to increase FFM but were for localised muscle and index measures, respectively. Combined, exercise and nutritional supplementation shows promise as a strategy to increase FFM in COPD. Anabolic steroids are efficacious for increasing FFM in COPD.

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“…During this session, engage the relevant limb muscles by flexing the knee and hooking the foot to prevent and improve muscle atrophy. Modern research has demonstrated that, with regard to skeletal muscle, appropriate exercise training can have an effect on peripheral skeletal muscle strength and limb mobility [ 25 ]. Simultaneously, the majority of anti-fibrotic IPF patients died of chronic respiratory failure; skeletal muscle loss is observed in these individuals, but there is no significant weight loss, which displays that preventing skeletal muscle atrophy in IPF patients is crucial [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Multiform-based Baduanjin exercise prevention and treatment for idiopathic pulmonary fibrosis: study protocol for a randomized controlled trial

et al. 2023

BMC Complement Med Ther

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Introduction In this study, we will combine the traditional Baduanjin with Yijin Jing and Wuqinxi to create an optimized Baduanjin exercise program with three different forms (vertical, sitting, and horizontal) to adapt to idiopathic pulmonary fibrosis (IPF) patients in vairous stages of the disease. The purpose of this study is to explore and compare the therapeutic effects of this multi-form Baduanjin, traditional Baduanjin, and resistance training on lung function and limb motor function in IPF patients. The goal of this study is to prove a novel optimal exercise prescription strategy of Baduanjin exercise for improving and protecting lung function in IPF patients. Methods/design A single-blind and randomized controlled trial is used to conduct this study, while the randomization list will be generated using a computerized random number generator and opaque sealed envelopes with group allocation will be prepared. It will be strictly followed to blind the outcome assessors. and until the experiment’s conclusion, participants won’t know which group they are enrolled in. Patients between the ages of 35 and 80 who have stable diseases and have not regularly practiced Baduanjin exercise in the past will be included. They are divvied up into the following five groups at random: (1) The conventional care group (control group, CG), (2) The traditional Baduanjin exercise group (TG), (3) The modified Baduanjin exercise group (IG), (4) The resistance exercise group (RG) (5) The modified Baduanjin exercise combined with resistance exercise group (IRG). Those CG participants only received the usual treatment, while TC, IG, and RG participants exercised 1 h twice a day for 3 months. MRG participants will have a 3-month intervention with 1 h of Modified Baduanjin Exercise and 1 H of Resistance Training for each day. Every week, all groups underwent will supervis one-day training, with the exception of the control group. The Pulmonary Function Testing (PFT), HRCT, and 6MWT are the main outcome variables. The St. George Respiratory Questionnaire and mMRC are used as secondary outcome measures. Discussion This study may produce a new Baduanjin exercise prescription that is user-friendly, simple to execute, more targeted, and adaptable. Because it consists of three forms, including vertical, sitting, and horizontal, it is more adaptable to the various disease stages and actual situations of IPF patients and may compensate for the shortcomings of conventional pulmonary rehabilitation and traditional Baduanjin. Trial registration Chinese Clinical Trial Registry, ChiCTR2200055559. Registered on 12 January 2022.

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Effects of Exercise Intervention on Peripheral Skeletal Muscle in Stable Patients With COPD: A Systematic Review and Meta-Analysis

Cited by 15 publications

References 61 publications

Muscle Power in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis

Muscle Power in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis

Efficacy of interventions to alter measures of fat-free mass in people with COPD: a systematic review and meta-analysis

Multiform-based Baduanjin exercise prevention and treatment for idiopathic pulmonary fibrosis: study protocol for a randomized controlled trial

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