Effects of exercise intervention in breast cancer survivors: a meta-analysis of 33 randomized controlled trails

Zhu, Guo‐Qing; Xiao, Zhou; Wang, Yulan; Xiong, Huizi; Zhao, Yinghui; Sun, Fenyong

doi:10.2147/ott.s97864

Cited by 103 publications

(113 citation statements)

References 78 publications

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“…included. Moreover, the meta-analytic results are not consistent with the lack of effect on sleep outcomes in a more recent meta-analysis examining exercise effects on sleep in breast cancer survivors specifically due, in part, to few studies all enrolling small sample sizes (39). Of note, the data reported here are the first sleep outcomes data from a large randomized controlled physical activity (walking or traditional supervised aerobic exercise) and cancer trial specifically focused on post-primary treatment breast cancer survivors.…”

Section: Discussionmentioning

confidence: 65%

“…Specifically, poor sleep is associated with greater breast cancer mortality (18,19) and being able to sleep is among the top 5 highest ranked patient-reported outcomes of importance (i.e., ranked as “important or very important” by 96% of breast cancer survivors) (13). Physical activity is one potential non-pharmacologic intervention for poor sleep quality (20,24) yet a recent meta-analysis reported no benefits of exercise interventions on sleep quality in breast cancer survivors (39). …”

Section: Introductionmentioning

confidence: 99%

“…The only large trial (301 participants) was carried out during chemotherapy (limiting generalizability to post-primary treatment survivors) and did not include an accelerometer or objective measure of sleep quality (10). Published scientific reviews including trials enrolling mixed or cancer types other than breast and testing a variety of exercise modes (e.g., resistance, yoga) also support inconsistencies in exercise effects on sleep among cancer survivors and the infrequent use of objective sleep measures (20,21,39). …”

Section: Introductionmentioning

confidence: 99%

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Physical Activity and Sleep Quality in Breast Cancer Survivors

Rogers

Courneya

Oster

et al. 2017

Medicine &Amp; Science in Sports &Amp; Exercise

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Purpose Data from large randomized controlled trials confirming sleep quality improvements with aerobic physical activity have heretofore been lacking for post-primary treatment breast cancer survivors. Our primary purpose for this report was to determine the effects of a physical activity behavior change intervention, previously reported to significantly increase physical activity behavior, on sleep quality in post-primary treatment breast cancer survivors. Methods Post-primary treatment breast cancer survivors (n=222) were randomized to a 3-month physical activity behavior change intervention (BEAT Cancer) or usual care. Self-report (Pittsburgh Sleep Quality Index [PSQI]) and actigraphy (latency and efficiency) sleep outcomes were measured at baseline, 3 months (M3), and 6 months (M6). Results After adjusting for covariates, BEAT Cancer significantly improved PSQI global sleep quality when compared with usual care at M3 (mean between group difference [M] = −1.4; 95% CI = −2.1 to −0.7; p < .001) and M6 (M = −1.0; 95% CI = −1.7 to −0.2; P = .01). BEAT Cancer improved several PSQI subscales at M3 (sleep quality M = −0.3; 95% CI = −0.4 to −0.1; P = .002; sleep disturbances M = −0.2; 95% CI = −0.3 to −0.03; P = .016; daytime dysfunction M = −0.2; 95% CI = −0.4 to −0.02; P = .027) but not M6. A non-significant increase in percent of participants classified as good sleepers occurred. No significant between group difference was noted for accelerometer latency or efficiency. Conclusion A physical activity intervention significantly reduced perceived global sleep dysfunction at 3 and 6 months, primarily due to improvements in sleep quality aspects not detected with accelerometer.

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Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Physical Activity and Sleep Quality in Breast Cancer Survivors

Rogers

Courneya

Oster

et al. 2017

Medicine &Amp; Science in Sports &Amp; Exercise

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“…Physical activity interventions also reduce depressive and anxiety symptoms in breast cancer survivors. 102 However, in a study of prostate cancer survivors in which depressive symptoms and anxiety were secondary outcomes, there was no effect of the physical activity intervention on mood. 103 …”

Section: Treatment Optionsmentioning

confidence: 99%

Anxiety and Depression in Cancer Survivors

Syrjala

2017

Medical Clinics of North America

243

146

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Synopsis Most cancer survivors adjust well to life after cancer but some experience persisting negative mood such as cancer-related fears, post-traumatic stress, anxiety, or depression. Mood fluctuations may not reach criteria for a clinical diagnosis but sub-clinical symptoms can interfere with quality of life. Females, and adolescents and young adults are particularly at risk for mood disturbances. Behavioral interventions such as cognitive behavioral therapy and pharmacological treatments can effectively treat these distressing emotions. Much of the research on managing emotional needs after cancer has been completed with breast cancer survivors and more work is needed with diverse groups of survivors.

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“…Furthermore, it has been reported that muscle-derived oncostatin M (OSM) and Irisin can decrease breast cancer cell viability, while SPARC inhibits tumorigenesis in the colon of exercising mice [115]. Herein, we have summarized the effects of physical exercise on other aspects of the body and overall health, such as inflammatory adipose tissue metabolism [103] sex hormones [116], leptin [102] and tumor factors [117], cardiopulmonary function [118][119][120], insulin resistance and sleep disorders [120], cachexia and lymphedema 2 , muscle mass and bone density [121], and genetic alteration [122] (Figure 1). …”

Section: Inflammatory Reactionsmentioning

confidence: 99%

Untitled

2017

JCPCR

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Potential Mechanisms behind Physical Exercise vs. Epigenetic Regulation for Preventing Breast CancerSubmit Manuscript | http://medcraveonline.com recent years, new applications in both diagnosis and treatment have gradually reduced female breast cancer incidence rates [1]. Considering alternative prevention and therapeutic methods, physical exercise has recently been gaining increased attention in the clinic. Regular exercise appears to lower breast cancer risk by about 10-20 percent, which is a considerable impact from a non-pharmacologic intervention with no cost. Thus, the recently emerging field of exercise-oncology research will be expected to not only clarify the mechanisms behind prevention, but also shed light on future treatment for breast cancer. In this current review, we will summarize recent studies on physical exercise with respect to breast cancer, and discuss their relationship and possible underlying mechanisms. Risk factors for breast cancerBreast cancer is the second most common type of cancer and the leading cause of cancer-related death in women worldwide (link: https://www.breastfriends.org). It is a tremendous disease, affecting lifespan and healthspan. The incidence of breast cancer is increasing every year, and an estimated 252,710 new cases of invasive breast cancer are expected to be diagnosed in women in the U.S. in 2017 (link: http://www.breastcancer.org/symptoms/ understand_bc/statistics). Throughout the world, every year more than 400,000 deaths are caused by breast cancer and, out of these diagnosed cases, there are more than 2.8 million breast cancer survivors [2].Generally, there are two aspects of risk factors for breast cancer (see Table1): (1) [68][69][70]. On the other hand, due to genetic susceptibility influences, which are inherited and unchangeable; the non-modifiable factors are not easily controllable risks for breast cancer. Therefore, it is feasible to reduce the risk factors that are not inherited, but can be changed. Among these modifiable risk factors, physical exercise behaviors not only are beneficial for preventing all stages of cancer development [71], but also are helpful to maintain a healthy weight and reduce risks for developing other diseases, such as cardiovascular disease, diabetes, and stroke [72]. Furthermore, physical activity (PA) has been increasingly regarded as the nonpharmacologic intervention for many cancer patients to combat both the physiologic and psychological effects of cancer treatment [73]. A recent World Health Organization (WHO) report shows that physical inactivity remains one of the most important risk factors for total cancer related mortality (responsible for 6% of total deaths) along with overweight and obesity (responsible for another 5%) [74]. AbstractBreast cancer is the most commonly diagnosed cancer and has been the second leading cause of death due to cancer among women worldwide. It is a disease in which malignant (cancer) cells form in the tissues of the breast and become deadly when they metastasize, spreading to oth...

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Effects of exercise intervention in breast cancer survivors: a meta-analysis of 33 randomized controlled trails

Cited by 103 publications

References 78 publications

Physical Activity and Sleep Quality in Breast Cancer Survivors

Physical Activity and Sleep Quality in Breast Cancer Survivors

Anxiety and Depression in Cancer Survivors

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