Effects of exercise-based interventions on inflammatory markers in patients with fibromyalgia: A systematic review and meta-analysis

Suso-Martí, Luis; Núñez-Cortés, Rodrigo; Sánchez-Sabater, Alberto; Garrigós-Pedrón, Miriam; Ferrer-Sargues, Francisco José; López-Bueno, Rubén; Calatayud, Joaquín

doi:10.1016/j.semarthrit.2024.152377

Cited by 1 publication

(1 citation statement)

References 58 publications

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“…A systematic search of several electronic databases demonstrated, through a meta-analysis, a significant reduction in ESR and pro-inflammatory interleukin IL-8 levels in patients with FM syndrome who practiced EBI. Although the authors themselves concluded that their work should be interpreted with caution, it represents a further suggestion to the inflammatory hypothesis in the pathogenesis of FM syndrome [ 153 ].…”

Section: Anti-inflammatory Activity Of Current Therapies In Fm Syndromementioning

confidence: 99%

Inflammation, Autoimmunity, and Infection in Fibromyalgia: A Narrative Review

Paroli,

Gioia,

Accapezzato

et al. 2024

IJMS

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Fibromyalgia (FM) is a chronic disease characterized by widespread musculoskeletal pain of unknown etiology. The condition is commonly associated with other symptoms, including fatigue, sleep disturbances, cognitive impairment, and depression. For this reason, FM is also referred to as FM syndrome. The nature of the pain is defined as nociplastic according to the latest international classification and is characterized by altered nervous sensitization both centrally and peripherally. Psychosocial conditions have traditionally been considered critical in the genesis of FM. However, recent studies in animal models and humans have provided new evidence in favor of an inflammatory and/or autoimmune pathogenesis. In support of this hypothesis are epidemiological data of an increased female prevalence, similar to that of autoimmune diseases, and the frequent association with immune-mediated inflammatory disorders. In addition, the observation of an increased incidence of this condition during long COVID revived the hypothesis of an infectious pathogenesis. This narrative review will, therefore, discuss the evidence supporting the immune-mediated pathogenesis of FM in light of the most current data available in the literature.

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Section: Anti-inflammatory Activity Of Current Therapies In Fm Syndromementioning

confidence: 99%