Effects of exclusive formula or breast milk feeding on oxidative stress in healthy preterm infants

Korchazhkina, Olga; Jones, Elizabeth; Czauderna, M.; Spencer, Stephen Andrew

doi:10.1136/adc.2005.084798

Cited by 22 publications

(13 citation statements)

References 26 publications

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“…These results demonstrate that human milk provides better antioxidant power than formula. Similar results were obtained by Ledo et al, in 2009, by comparing 29 breastfed and 34 formula fed babies (using several urinary markers for On the other hand, Korchazhkina et al (2006) collected samples of milk from 20 mothers who had had premature babies and urine of the milk fed babies (10 breast-fed and 10 formula-fed, 4-6 days old) and reported the malondialdehyde levels (a marker of lipid peroxidation) in those samples. The conclusion withdrawn was that both breast milk and formula were sufficient to prevent lipid peroxidation in healthy preterm newborns.…”

Section: Teac (Abts)supporting

confidence: 66%

Breastfeeding: Antioxidative properties of breast milk

Matos¹,

Ribeiro

Guerra

2015

JAB

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Birth is an event that exposes the newborn baby to a high concentration of free radicals (reactive oxygen species (ROS) / reactive nitrogen species (RNS)), which can contribute to several diseases. The balanced equilibrium between ROS / RNS and the antioxidant system of the newborn is a key factor in preventing a plethora of diseases. The antioxidant system involves endogenous and exogenous molecules, from vitamins (A, E, C), to enzymes (glutathione peroxidase, superoxide dismutase), metals (copper (Cu), zinc (Zn), and selenium (Se)) and other molecules (coenzyme Q 10 , melatonin) that can act in a synergistic manner to deactivate free radicals. A competent antioxidant system of the baby is strongly dependent on the intake of free radical deactivating molecules from feeding, either maternal or formula milk, with several studies pointing that breast milk has more powerful antioxidant effects on lowering the infant´s oxidative status. An improved understanding of the antioxidant molecules, their mechanism of action, and the relationships between them, are key factors to comprehend all the potential benefits of human breastfeeding in this matter. The purpose of this review is to describe different research efforts and methodologies of evaluation of total antioxidant system (TAS) in human milk, and to evaluate and summarize the contribution of different antioxidant molecules in TAS, with special emphasis in the last 10 years.

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Section: Teac (Abts)supporting

confidence: 66%

Breastfeeding: Antioxidative properties of breast milk

Matos¹,

Ribeiro

Guerra

2015

JAB

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“…In healthy preterm infants, very low concentrations of markers of oxidative stress have been previously reported. 23 In an attempt to limit other than LCPUFA factors that might have an impact on oxidative stress, 8,12,24,25 for example, infection or oxygen supply, we applied strict criteria so that only healthy preterm infants were included in the study. In addition, the following parameters that might have contributed to oxidative stress, such as number of erythrocyte transfusions, number of infants who were given iron supplements, days needed to establish full enteral feeding, caloric intake, growth rates/body weight balance, and gestational and postnatal age, did not differ significantly between the two infant groups.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress in Preterm Infants Fed a Formula Containing Long-Chain Polyunsaturated Fatty Acids (LCPUFA)

et al. 2007

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Our study examined if dietary long-chain polyunsaturated fatty acids (LCPUFA) have an impact on oxidative stress in preterm infants. Serum malonyldialdehyde (MDA), total peroxide concentrations, and total antioxidant capacity were determined at mean (standard deviation [SD]) 34.7 (10.9) days of life in 104 healthy preterm infants (gestational age, 32.6 [2.9] weeks; birthweight; 1605 [285] g) who were randomly assigned to be fed since birth either a formula containing LCPUFA (arachidonic and docosahexaenoic) (group A, n = 50) or a LCPUFA-free formula with identical compositions for other nutrients (group B, n = 54). Clinical and anthropometric characteristics did not differ significantly between the two groups. Mean (SD) serum MDA levels did not differ significantly between groups A (0.23 [0.04] micromol/L) and B (0.22 [0.05] micromol/L). The concentrations of total peroxides were below the detection limits of the assay in 41 of 50 (82%) infants of group A and 43 of 54 (79%) infants of group B and not significantly different between the two infant groups. No difference was observed in serum total antioxidant capacity between groups A (340.0 [46.2] micromol/L) and B (354.7 [46.5] micromol/L). We concluded that supplementation of infant formulas with LCPUFA does not affect lipid peroxidation in healthy preterm infants.

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“…Despite the lowering effect of tobacco smoking on these vitamins, breast feeding seemed to compensate this loss of antioxidant capacity and decrease the oxidative stress in infants. Although Korchazhkina et al (25) found that antioxidant capacity of both breast milk and formulae is sufficient to prevent significant lipid peroxidation in a limited number of healthy premature infants, in a study on 54 healthy term infants, it has been demonstrated that breast milk provides a better antioxidant power than does formula (26). Apparently, if tobacco‐smoke exposure of infants cannot be prevented, continuation of breast feeding may help to prevent decrements in vitamin levels and antioxidant capacity (26–30).…”

Section: Discussionmentioning

confidence: 99%

The effect of passive smoking and breast feeding on serum antioxidant vitamin (A, C, E) levels in infants

Yılmaz¹,

Ağras²,

Hızlı³

et al. 2009

Acta Paediatrica

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Effects of exclusive formula or breast milk feeding on oxidative stress in healthy preterm infants

Abstract: Antioxidant properties of both breast milk and formulae are sufficient to prevent significant lipid peroxidation in healthy premature infants.

Cited by 22 publications

References 26 publications

Breastfeeding: Antioxidative properties of breast milk

Breastfeeding: Antioxidative properties of breast milk

Oxidative Stress in Preterm Infants Fed a Formula Containing Long-Chain Polyunsaturated Fatty Acids (LCPUFA)

The effect of passive smoking and breast feeding on serum antioxidant vitamin (A, C, E) levels in infants

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