Effects of exclusive breastfeeding on infant gut microbiota: a meta-analysis across studies and populations

Nt, Ho; F, Li; Ka, Lee-Sarwar; Tun, Hein Min; Brown, Bryan P.; Ps, Pannaraj; Jm, Bender; Mb, Azad; Al, Thompson; St, Weiss; Ma, Azcarate-Peril; Litonjua, AA; Al, Kozyrskyj; Hb, Jaspan; Gm, Aldrovandi; Kuhn, Louise

doi:10.1101/292755

Cited by 6 publications

(9 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with the BF group, the MF and FF groups were more related to fatty acid biosynthesis and biosynthesis of unsaturated fatty acid. It was opposite with the result of Nhan (Ho et al, 2018). These findings may provide insight into biological mechanisms for the adverse health outcomes of children that were not BF or non-exclusively BF in early months of life (Stuebe, 2009;Cardwell et al, 2012;Yan et al, 2014).…”

Section: Discussionmentioning

confidence: 80%

Distinct Gut Microbiota and Metabolite Profiles Induced by Different Feeding Methods in Healthy Chinese Infants

Yan

Wang

et al. 2020

Front. Microbiol.

View full text Add to dashboard Cite

Human milk is closely correlated with infant gut microbiota and is important for infant development. However, most infants receive exclusively insufficient breast milk, and the discordance between effects of commercial formula and human milk exists. To elucidate the differences induced by various feeding methods, we determined microbiota and metabolites composition in fecal samples from 77 healthy infants in Northeast China and identified the differences in various feeding methods. Bacterial 16S rRNA gene sequence analysis demonstrated that the fecal samples of exclusively breastfed (BF) infants were abundant in Bifidobacterium and Lactobacillus; the mixed-fed (MF) infants had the highest abundance of Veillonella and Klebsiella; the exclusively formula-fed (FF) infants were enriched in Bacteroides and Blautia; and the complementary food-fed (CF) infants were associated with higher relative abundance of Lachnoclostridium and Akkermansia. Liquid chromatography-mass spectrometry (LC-MS)-based metabolomics data revealed that the fecal samples of BF infants had the highest abundance of DL-citrulline, threonine, L-proline, L-glutamine, guanine, and L-arginine; the MF infants were abundant in D-maltose, stearidonic acid, capric acid, and myristic acid; the FF infants were enriched in itaconic acid, 4-pyridoxic acid, prostaglandin B2, thymine, DL-α-hydroxybutyric acid, and orotic acid; and the CF infants were associated with higher relative abundance of taurine, L-tyrosine, adenine, and uric acid. Furthermore, compared with the BF infants, the MF and FF infants were more abundant in fatty acid biosynthesis. Collectively, these findings will provide probable explanations for some of the risks and benefits related to infant feeding methods and will support a theoretical basis for the development of infant formula.

show abstract

Section: Discussionmentioning

confidence: 80%

Distinct Gut Microbiota and Metabolite Profiles Induced by Different Feeding Methods in Healthy Chinese Infants

Yan

Wang

et al. 2020

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…The infant and child microbiota is susceptible to a range of environmental influences, from birth mode (vaginal vs. Csection) (156,454), prematurity (540a), and birth location (home vs. hospital) (331) to diet (including breastfeeding vs. formula feeding) (77,671,1681), maternal gestational diet and weight gain (1352), pet ownership (77a, 1519), physical illness (757), antibiotic use (835,1647), and stress (235,621,1688). Although some of these factors exert a diminishing influence on the microbiota over time (e.g., the effects of birth mode on microbiota composition are no longer apparent by 6 wk of age; Refs.…”

Section: A Early Lifementioning

confidence: 99%

The Microbiota-Gut-Brain Axis

Cryan

O’Riordan

Cowan

et al. 2019

Physiological Reviews

2,535

2,066

View full text Add to dashboard Cite

The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms within and on our bodies) as one of the key regulators of gut-brain function and has led to the appreciation of the importance of a distinct microbiota-gut-brain axis. This axis is gaining ever more traction in fields investigating the biological and physiological basis of psychiatric, neurodevelopmental, age-related, and neurodegenerative disorders. The microbiota and the brain communicate with each other via various routes including the immune system, tryptophan metabolism, the vagus nerve and the enteric nervous system, involving microbial metabolites such as short-chain fatty acids, branched chain amino acids, and peptidoglycans. Many factors can influence microbiota composition in early life, including infection, mode of birth delivery, use of antibiotic medications, the nature of nutritional provision, environmental stressors, and host genetics. At the other extreme of life, microbial diversity diminishes with aging. Stress, in particular, can significantly impact the microbiota-gut-brain axis at all stages of life. Much recent work has implicated the gut microbiota in many conditions including autism, anxiety, obesity, schizophrenia, Parkinson’s disease, and Alzheimer’s disease. Animal models have been paramount in linking the regulation of fundamental neural processes, such as neurogenesis and myelination, to microbiome activation of microglia. Moreover, translational human studies are ongoing and will greatly enhance the field. Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.

show abstract

“…Such changes impact on maternal and offspring health, altering host metabolic pathways and remodeling the expression of genes regulating them (Gaillard et al, 2013;Galley et al, 2014;Gallardo et al, 2015;Gohir et al, 2015;Kumbhare et al, 2019). Furthermore, evidence shows that breastfeeding is one of the key players in preventing alteration in gut microbiota composition, which likely contributes to the development of autoimmune and metabolic disorders later in life (Ho et al, 2018). Human milk contains remarkable bioactive compounds, including human milk oligosaccharides, HMOs, beneficial to infants as they not only promote a better growth but also strengthen the immune system of the newborn, reducing the risk of diarrhea and consequent dehydration, protecting against allergies and metabolic disorders (Ho et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Early Life Microbiota Colonization at Six Months of Age: A Transitional Time Point

Raspini

Vacca

Porri

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

BackgroundEarly life gut microbiota is involved in several biological processes, particularly metabolism, immunity, and cognitive neurodevelopment. Perturbation in the infant’s gut microbiota increases the risk for diseases in early and later life, highlighting the importance of understanding the connections between perinatal factors with early life microbial composition. The present research paper is aimed at exploring the prenatal and postnatal factors influencing the infant gut microbiota composition at six months of age.MethodsGut microbiota of infants enrolled in the longitudinal, prospective, observational study “A.MA.MI” (Alimentazione MAmma e bambino nei primi MIlle giorni) was analyzed. We collected and analyzed 61 fecal samples at baseline (meconium, T0); at six months of age (T2), we collected and analyzed 53 fecal samples. Samples were grouped based on maternal and gestational weight factors, type of delivery, type of feeding, time of weaning, and presence/absence of older siblings. Alpha and beta diversities were evaluated to describe microbiota composition. Multivariate analyses were performed to understand the impact of the aforementioned factors on the infant’s microbiota composition at six months of age.ResultsDifferent clustering hypotheses have been tested to evaluate the impact of known metadata factors on the infant microbiota. Neither maternal body mass index nor gestational weight gain was able to determine significant differences in infant microbiota composition six months of age. Concerning the type of feeding, we observed a low alpha diversity in exclusive breastfed infants; conversely, non-exclusively breastfed infants reported an overgrowth of Ruminococcaceae and Flavonifractor. Furthermore, we did not find any statistically significant difference resulting from an early introduction of solid foods (before 4 months of age). Lastly, our sample showed a higher abundance of clostridial patterns in firstborn babies when compared to infants with older siblings in the family.ConclusionOur findings showed that, at this stage of life, there is not a single factor able to affect in a distinct way the infants’ gut microbiota development. Rather, there seems to be a complex multifactorial interaction between maternal and neonatal factors determining a unique microbial niche in the gastrointestinal tract.

show abstract

Effects of exclusive breastfeeding on infant gut microbiota: a meta-analysis across studies and populations

Cited by 6 publications

References 54 publications

Distinct Gut Microbiota and Metabolite Profiles Induced by Different Feeding Methods in Healthy Chinese Infants

Distinct Gut Microbiota and Metabolite Profiles Induced by Different Feeding Methods in Healthy Chinese Infants

The Microbiota-Gut-Brain Axis

Early Life Microbiota Colonization at Six Months of Age: A Transitional Time Point

Contact Info

Product

Resources

About