Effects of Excess Weight on Cancer Incidences Depending on Cancer Sites and Histologic Findings Among Men: Korea National Health Insurance Corporation Study

Oh, Sang Woo; Yoon, Yeong Sook; Shin, Soon Ae

doi:10.1200/jco.2005.11.726

Cited by 359 publications

(292 citation statements)

References 34 publications

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“…We identified 11 eligible cohort studies (Møller et al, 1994;Wolk et al, 2001;Nair et al, 2002;Calle et al, 2003;Samanic et al, 2004Samanic et al, , 2006Batty et al, 2005;Kuriyama et al, 2005;Oh et al, 2005;Rapp et al, 2005;N'Kontchou et al, 2006), of which 7 on overweight (with a total of 5037 cases) (Calle et al, 2003;Batty et al, 2005;Kuriyama et al, 2005;Oh et al, 2005;Rapp et al, 2005;N'Kontchou et al, 2006;Samanic et al, 2006) and 10 on obesity (with a total of 6042 cases) (Møller et al, 1994;Wolk et al, 2001;Nair et al, 2002;Calle et al, 2003;Samanic et al, 2004Samanic et al, , 2006Batty et al, 2005;Oh et al, 2005;Rapp et al, 2005;N'Kontchou et al, 2006) were suitable for metaanalysis. Characteristics of the studies are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…With stratification by assessment of obesity, the summary relative risks for the association between obesity and liver cancer were 2.15 (95% CI: 1.66 -2.77) for studies based on measured or self-reported weight and height (Nair et al, 2002;Calle et al, 2003;Batty et al, 2005;Oh et al, 2005;Rapp et al, 2005;N'Kontchou et al, 2006;Samanic et al, 2006) and 1.61 (95% CI: 1.14 -2.27) for studies based on a discharge diagnosis of obesity (Møller et al, 1994;Wolk et al, 2001;Samanic et al, 2004).…”

Section: Resultsmentioning

confidence: 99%

“…Heavy, long-term alcohol consumption is also a risk factor (Yu and Yuan, 2004). None of the studies adjusted for hepatitis B or C virus infections, and only three (Calle et al, 2003;Kuriyama et al, 2005;Oh et al, 2005) controlled for alcohol intake. It is unlikely, however, that these risk factors are strongly related to body weight and entirely explain the observed relationship between excess body weight and liver cancer risk.…”

Section: Discussionmentioning

confidence: 99%

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Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies

2007

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Cohort studies of excess body weight and risk of liver cancer were identified for a meta-analysis by searching MEDLINE and EMBASE databases from 1966 to June 2007 and the reference lists of retrieved articles. Results from individual studies were combined using a random-effects model. We identified 11 cohort studies, of which seven on overweight (with a total of 5037 cases) and 10 on obesity (with 6042 cases) were suitable for meta-analysis. Compared with persons of normal weight, the summary relative risks of liver cancer were 1.17 (95% confidence interval (CI): 1.02 -1.34) for those who were overweight and 1.89 (95% CI: 1.51 -2.36) for those who were obese. This meta-analysis finds that excess body weight is associated with an increased risk of liver cancer. Although relatively rare in the United States and other developed countries, liver cancer is the third most common cause of death from cancer worldwide (Parkin et al, 2005). It is rarely detected early and is often fatal within a few months of diagnosis. The 5-year survival rate is only about 6 -11% (Coleman et al, 2003;Ries et al, 2006). The age-adjusted incidence and mortality rates of liver cancer have been increasing rapidly in the United States since the mid-1980s (Ries et al, 2006). While approximately half of this increase can be attributable to hepatitis C virus infection, a minimal or no increase has been related to hepatitis B virus and alcoholic liver disease (El-Serag and Mason, 2000;Hassan et al, 2002). Given that about half of the increase in liver cancer incidence is not related to hepatitis, the major risk factor in a significant proportion of the cases has yet to be identified.Coinciding with the rising incidence of liver cancer, the prevalence of obesity has been increasing markedly over the past two decades worldwide (Larsson and Wolk, 2006). Obesity has been recognised as a risk factor for several malignancies, including cancer of the breast (in premenopausal women), endometrium, kidney (renal cell), colon, pancreas, gallbladder, and esophagus (adenocarcinoma) (IARC, 2002;. Accumulating epidemiologic evidence also indicates that excess body weight may be a risk factor for liver cancer, but the evidence has not been quantitatively summarised. We have therefore quantitatively assessed the associations of overweight and obesity with liver cancer risk in a meta-analysis of cohort studies. MATERIALS AND METHODS Study selectionA literature search was conducted in the MEDLINE and EMBASE databases for pertinent studies published in any language from 1966 to June 2007. We used the keywords 'body mass index', 'BMI', or 'obesity' in combination with 'hepatocellular carcinoma', 'liver cancer', or 'liver neoplasm'. Moreover, we manually reviewed the reference lists of retrieved articles to search for more studies.Studies were included in the meta-analysis if they fulfilled the following criteria: (1) cohort study in which liver cancer incidence or mortality was an outcome; (2) the exposure of interest was overweight and/or obesity defined by body ma...

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies

2007

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“…The eight cohort studies Wolk et al, 2001;Calle et al, 2003;Samanic et al, 2004Samanic et al, , 2006Engeland et al, 2005;Kuriyama et al, 2005;Oh et al, 2005) and three case -control studies Zatonski et al, 1997;Serra et al, 2002) that were included in the meta-analysis involved a total of 3288 cases. Main characteristics of the studies are shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…We identified eight cohort studies Wolk et al, 2001;Calle et al, 2003;Samanic et al, 2004Samanic et al, , 2006Engeland et al, 2005;Kuriyama et al, 2005;Oh et al, 2005) and four case -control studies (Zatonski et al, 1992(Zatonski et al, , 1997Strom et al, 1995;Serra et al, 2002) that reported results on overweight/obesity and risk of gallbladder cancer. One case -control study (Zatonski et al, 1992) was excluded because this study was included in a multicentre case -control study (Zatonski et al, 1997); the multicentre casecontrol study was included in this meta-analysis.…”

Section: Study Selectionmentioning

confidence: 99%

Obesity and the risk of gallbladder cancer: a meta-analysis

2007

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We performed a meta-analysis of studies of the association between excess body weight and risk of gallbladder cancer identified from MEDLINE and EMBASE databases from 1966 to February 2007 and the references of retrieved articles. A random-effects model was used to combine results from eight cohort studies and three case -control studies, with a total of 3288 cases. Compared with individuals of 'normal weight', the summary relative risk of gallbladder cancer for those who were overweight or obese was 1.15 (95% CI, 1.01 -1.30) and 1.66 (95% CI, 1.47 -1.88) respectively. The association with obesity was stronger for women (relative risk, 1.88; 95% CI, 1.66 -2.13) than for men (relative risk, 1.35; 95% CI, 1.09 -1.68). There was no statistically significant heterogeneity among the results of individual studies. This meta-analysis confirms the association between excess body weight and risk of gallbladder cancer.

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Anthropometric Measures, Body Mass Index, and Pancreatic Cancer

Arslan¹,

Helzlsouer²,

Kooperberg³

et al. 2010

Arch Intern Med

318

105

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Background Pooled data were analyzed from the NCI Pancreatic Cancer Cohort Consortium (PanScan) to study the association between pre-diagnostic anthropometric measures and risk of pancreatic cancer. Methods PanScan applied a nested case-control study design and included 2,170 cases and 2,209 controls. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression for cohort-specific quartiles of body mass index (BMI), weight, height, waist circumference, and waist-to-hip ratio (WHR), as well as conventional BMI categories: underweight (<18.5 kg/m2), normal (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2), obese (30.0-34.9 kg/m2), and severely obese (≥35.0 kg/m2). Models were adjusted for potential confounders. Results Among all subjects, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjusted OR for the highest vs. lowest BMI quartile = 1.33, 95% CI = 1.12-1.58, Ptrend < 0.001). Among men, the adjusted OR for pancreatic cancer for the highest vs. lowest quartile of BMI was 1.33 (95% CI = 1.04-1.69, Ptrend <0.03). Among women, the adjusted OR for pancreatic cancer for the highest quartile of BMI was 1.34 (95% CI = 1.05-1.70, Ptrend = 0.01). Increased WHR was associated with increased risk of pancreatic cancer among women (adjusted OR for the highest vs. lowest quartile = 1.87, 95% CI = 1.31-2.69, Ptrend = 0.003) but less so in men. Conclusion The findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women.

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Effects of Excess Weight on Cancer Incidences Depending on Cancer Sites and Histologic Findings Among Men: Korea National Health Insurance Corporation Study

Cited by 359 publications

References 34 publications

Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies

Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies

Obesity and the risk of gallbladder cancer: a meta-analysis

Anthropometric Measures, Body Mass Index, and Pancreatic Cancer

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