Effects of excess sucrose ingestion on the life span of hypertensive rats (SHR)

Preuss, Harry G.; Zein, Mohmed; Areas, Jorge; Podlasek, Stanley J.; Knapka, Joseph J.; Antonovych, Tatiana T.; Sabnis, Sharda G.; Zepeda, H

doi:10.1007/bf00451857

Cited by 9 publications

(4 citation statements)

References 8 publications

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“…In rats, sucrose supplemented diets shorten mean lifespan and elevate blood pressure. In the fruit fly ( Drosophila melanogaster ) sucrose reduced lifespan and increased levels of body fat (Preuss et al, 1991, Rovenko et al, 2015). Our results showed no change in lifespan with sucrose.…”

Section: Discussionmentioning

confidence: 99%

Lower Doses of Fructose Extend Lifespan inCaenorhabditis elegans

Zheng

Gao

Wang

et al. 2016

Journal of Dietary Supplements

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Epidemiological studies indicate that the increased consumption of sugars including sucrose and fructose in beverages correlate with the prevalence of obesity, type-2 diabetes, insulin resistance, hyperinsulinemia, hypertriglyceridemia, and hypertension in humans. A few reports suggest that fructose extends lifespan in Saccharomyces cerevisiae. In Anopheles gambiae, fructose, glucose, or glucose plus fructose also extended lifespan. New results presented here suggest that fructose extends lifespan in Caenorhabditis elegans (C. elegans) wild type (N2). C. elegans were fed standard laboratory food source (E. coli OP50), maintained in liquid culture. Experimental groups received additional glucose (111 mM), fructose (55 mM, 111 mM, or 555 mM), sucrose (55 mM, 111 mM, or 555 mM), glucose (167 mM) plus fructose (167 mM) (G&F), or high fructose corn syrup (HFCS, 333 mM). In four replicate experiments, fructose dose-dependently increased mean lifespan at 55 mM or 111 m Min N2, but decreased lifespan at 555 mM (P < 0.001). Sucrose did not affect the lifespan. Glucose reduced lifespan (P < 0.001). Equal amount of G&F or HFCS reduced lifespan (P < 0.0001). Intestinal fat deposition (IFD) was increased at a higher dose of fructose (555 mM), glucose (111 mM), and sucrose (55 mM, 111 mM, and 555 mM). Here we report a biphasic effect of fructose increasing lifespan at lower doses and shortening lifespan at higher doses with an inverse effect on IFD. In view of reports that fructose increases lifespan in yeast, mosquitoes and now nematodes, while decreasing fat deposition (in nematodes) at lower concentrations, further research into the relationship of fructose to lifespan and fat accumulation in vertebrates and mammals is indicated.

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Section: Discussionmentioning

confidence: 99%

Lower Doses of Fructose Extend Lifespan inCaenorhabditis elegans

Zheng

Gao

Wang

et al. 2016

Journal of Dietary Supplements

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“…Dietary protein was the main focus of early studies because it was thought that CR increased lifespan by delaying growth, and it was known that protein was important for growth. Most studies [144–149] but not all [150–152] found that reducing the protein content in the diet led to a longer lifespan in ad libitum fed animals. However, CR had a greater effect on lifespan than ad libitum fed low protein diets, even when both groups consumed the same amounts of protein [153].…”

Section: Macronutrients and The Geometric Frameworkmentioning

confidence: 99%

Does diet influence aging? Evidence from animal studies

et al. 2022

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Nutrition profoundly influences the risk for many age‐related diseases. Whether nutrition influences human aging biology directly is less clear. Studies in different animal species indicate that reducing food intake (“caloric restriction” [CR]) can increase lifespan and delay the onset of diseases and the biological hallmarks of aging. Obesity has been described as “accelerated aging” and therefore the lifespan and health benefits generated by CR in both aging and obesity may occur via similar mechanisms. Beyond calorie intake, studies based on nutritional geometry have shown that protein intake and the interaction between dietary protein and carbohydrates influence age‐related health and lifespan. Studies where animals are calorically restricted by providing free access to diluted diets have had less impact on lifespan than those studies where animals are given a reduced aliquot of food each day and are fasting between meals. This has drawn attention to the role of fasting in health and aging, and exploration of the health effects of various fasting regimes. Although definitive human clinical trials of nutrition and aging would need to be unfeasibly long and unrealistically controlled, there is good evidence from animal experiments that some nutritional interventions based on CR, manipulating dietary macronutrients, and fasting can influence aging biology and lifespan.

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“…However, Zheng et al (2017) found the treating C. elegans with sucrose had no signi cant effect on the organism's mean lifespan 62 . In rats, sucrose has been found to shorten the mean lifespan and elevate the blood pressure 63 . Rovenko et al (2015) showed that in D. melanogaster, high sucrose consumption decelerated pupation, increased pupa mortality and promoted obesity 64 .…”

Section: Organooxygen Compoundsmentioning

confidence: 99%

Random forest classification for predicting lifespan-extending chemical compounds

Kapsiani

Howlin

2021

Preprint

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Ageing is a major risk factor for many conditions including cancer, cardiovascular and neurodegenerative diseases. Pharmaceutical interventions that slow down ageing and delay the onset of age-related diseases are a growing research area. The aim of this study was to build a machine learning model based on the data of the DrugAge database to predict whether a chemical compound will extend the lifespan of Caenorhabditis elegans. Five predictive models were built using the random forest algorithm with molecular fingerprints and/or molecular descriptors as features. The best performing classifier, built using molecular descriptors, achieved an area under the curve (AUC) score of 0.815 for classifying the compounds in the test set. The features of the model were ranked using the Gini importance measure of the random forest algorithm. The top 30 features included descriptors related to atom and bond counts, topological and partial charge properties. The model was applied to predict the class of compounds in an external database, consisting of 1,738 small-molecules. The chemical compounds of the screening database with a predictive probability of ≥ 0.80 for increasing the lifespan of Caenorhabditis elegans were broadly separated into (i) flavonoids, (ii) fatty acids and conjugates, and (iii) organooxygen compounds.

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Effects of excess sucrose ingestion on the life span of hypertensive rats (SHR)

Cited by 9 publications

References 8 publications

Lower Doses of Fructose Extend Lifespan inCaenorhabditis elegans

Lower Doses of Fructose Extend Lifespan inCaenorhabditis elegans

Does diet influence aging? Evidence from animal studies

Random forest classification for predicting lifespan-extending chemical compounds

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