Effects of Eurocollins Solution as Aortic Flush for the Procurement of Human Pancreas

Gonzalez, A.M.; Filho, Gaspar Jesus Lopes; Pestana, José Osmar Medina; Linhares, Marcelo Moura; Silva, Maria Helena G; Moura, Ricardo P.; Melaragno, Cláudio S.; Sá, João Roberto de; Rangel, Erica B; Triviño, Tarcísio

doi:10.1097/01.tp.0000177640.53848.3d

Cited by 12 publications

(14 citation statements)

References 35 publications

(34 reference statements)

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“…2 Also, in 1 small cohort analysis, initial flushing with Eurocollins followed by Belzer preservation solution did not influence the outcomes of combined pancreas and kidney transplantation compared with Belzer solution alone. 22 …”

Section: Discussionmentioning

confidence: 99%

Randomized Trial of Machine Perfusion Versus Cold Storage in Recipients of Deceased Donor Kidney Transplants With High Incidence of Delayed Graft Function

Tedesco‐Silva

Offerni

Carneiro

et al. 2017

Transplantation Direct

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BackgroundThis study compared the use of static cold storage versus continuous hypothermic machine perfusion in a cohort of kidney transplant recipients at high risk for delayed graft function (DGF).MethodsIn this national, multicenter, and controlled trial, 80 pairs of kidneys recovered from brain-dead deceased donors were randomized to cold storage or machine perfusion, transplanted, and followed up for 12 months. The primary endpoint was the incidence of DGF. Secondary endpoints included the duration of DGF, hospital stay, primary nonfunction, estimated glomerular filtration rate, acute rejection, and allograft and patient survivals.ResultsMean cold ischemia time was high but not different between the 2 groups (25.6 ± 6.6 hours vs 25.05 ± 6.3 hours, 0.937). The incidence of DGF was lower in the machine perfusion compared with cold storage group (61% vs. 45%, P = 0.031). Machine perfusion was independently associated with a reduced risk of DGF (odds ratio, 0.49; 95% confidence interval, 0.26-0.95). Mean estimated glomerular filtration rate tended to be higher at day 28 (40.6 ± 19.9 mL/min per 1.73 m2 vs 49.0 ± 26.9 mL/min per 1.73 m2; P = 0.262) and 1 year (48.3 ± 19.8 mL/min per 1.73 m2 vs 54.4 ± 28.6 mL/min per 1.73 m2; P = 0.201) in the machine perfusion group. No differences in the incidence of acute rejection, primary nonfunction (0% vs 2.5%), graft loss (7.5% vs 10%), or death (8.8% vs 6.3%) were observed.ConclusionsIn this cohort of recipients of deceased donor kidneys with high mean cold ischemia time and high incidence of DGF, the use of continuous machine perfusion was associated with a reduced risk of DGF compared with the traditional cold storage preservation method.

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Section: Discussionmentioning

confidence: 99%

Randomized Trial of Machine Perfusion Versus Cold Storage in Recipients of Deceased Donor Kidney Transplants With High Incidence of Delayed Graft Function

Tedesco‐Silva

Offerni

Carneiro

et al. 2017

Transplantation Direct

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show abstract

“…The search for more favorable cost-benefit alternatives in comparison to the very expensive Belzer solution, which is traditionally the best option for preserving the pancreas for transplantation, resulted in the use of different combinations of preservation solutions in the donors included in the present study. 18 Although it may be valid to question the influence of such heterogeneity in the results presented in this study, percentage comparisons involving the use of different combinations of preservation solutions in these groups of patients had no statistically significant differences, suggesting that different methods of organ preservation did not have significant influence on the development of DPGF.…”

Section: Discussionmentioning

confidence: 78%

Impacto da função retardada do enxerto pancreático no transplante simultâneo pâncreas-rim

Baitello¹,

Galante²,

Coutinho³

et al. 2011

J. Bras. Nefrol.

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“…All grafts were perfused during the harvesting process through infusion of the aorta using standard solutions (Belzer or Celsior) as described previously [13].…”

Section: Methodsmentioning

confidence: 99%

Euro-Collins Solution for a Lower-Cost Preservation of Donor’s Pancreas

Gonzalez¹,

Fuziy²,

Filho³

et al. 2014

JED

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Effects of Eurocollins Solution as Aortic Flush for the Procurement of Human Pancreas

Abstract: Perfusion with 1 L of Eurocollins solution followed by 1 L of Belzer solution during pancreas harvesting seems to be a simple and efficient alternative for reducing the costs of the harvesting process.

Cited by 12 publications

References 35 publications

Randomized Trial of Machine Perfusion Versus Cold Storage in Recipients of Deceased Donor Kidney Transplants With High Incidence of Delayed Graft Function

Randomized Trial of Machine Perfusion Versus Cold Storage in Recipients of Deceased Donor Kidney Transplants With High Incidence of Delayed Graft Function

Impacto da função retardada do enxerto pancreático no transplante simultâneo pâncreas-rim

Euro-Collins Solution for a Lower-Cost Preservation of Donor’s Pancreas

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