Effects of Eugenol on Alzheimer’s Disease-like Manifestations in Insulin- and Aβ-Induced Rat Models

Taheri, Parastoo; Yaghmaei, Parichehreh; Tehrani, Hessam Sepasi; Ebrahim‐Habibi, Azadeh

doi:10.1007/s11062-019-09801-z

Cited by 20 publications

(12 citation statements)

References 22 publications

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“…In low to moderate doses, caffeine inhibits AChE, thereby improving cognitive actions and reducing the progression of AD [ 191 ]. Eugenol, found in cloves, has been reported to reduce amyloid plagues and increase memory in rat models induced with Aβ peptides [ 192 ]. Dietary patterns have also been found to impact the onset and progression of AD.…”

Section: Role Of Other Nutrients In Alzheimer’s Diseasementioning

confidence: 99%

Antioxidants in Alzheimer’s Disease: Current Therapeutic Significance and Future Prospects

Pritam

Deka

Bhardwaj

et al. 2022

Biology

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Alzheimer’s disease (AD) rate is accelerating with the increasing aging of the world’s population. The World Health Organization (WHO) stated AD as a global health priority. According to the WHO report, around 82 million people in 2030 and 152 million in 2050 will develop dementia (AD contributes 60% to 70% of cases), considering the current scenario. AD is the most common neurodegenerative disease, intensifying impairments in cognition, behavior, and memory. Histopathological AD variations include extracellular senile plaques’ formation, tangling of intracellular neurofibrils, and synaptic and neuronal loss in the brain. Multiple evidence directly indicates that oxidative stress participates in an early phase of AD before cytopathology. Moreover, oxidative stress is induced by almost all misfolded protein lumps like α-synuclein, amyloid-β, and others. Oxidative stress plays a crucial role in activating and causing various cell signaling pathways that result in lesion formations of toxic substances, which foster the development of the disease. Antioxidants are widely preferred to combat oxidative stress, and those derived from natural sources, which are often incorporated into dietary habits, can play an important role in delaying the onset as well as reducing the progression of AD. However, this approach has not been extensively explored yet. Moreover, there has been growing evidence that a combination of antioxidants in conjugation with a nutrient-rich diet might be more effective in tackling AD pathogenesis. Thus, considering the above-stated fact, this comprehensive review aims to elaborate the basics of AD and antioxidants, including the vitality of antioxidants in AD. Moreover, this review may help researchers to develop effectively and potentially improved antioxidant therapeutic strategies for this disease as it also deals with the clinical trials in the stated field.

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Section: Role Of Other Nutrients In Alzheimer’s Diseasementioning

confidence: 99%

Antioxidants in Alzheimer’s Disease: Current Therapeutic Significance and Future Prospects

Pritam

Deka

Bhardwaj

et al. 2022

Biology

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“…In order to simulate part of the AD signs, abeta amyloid is injected to the animals hippocampus, which results into plaque formation and troubles in learning. Candidate ligands that were administered to the AD animal models, and could attenuate their symptoms to some extent included indole and trans-chalcone [ 96 ], sylimarin [ 97 ], metformin [ 98 ], thymol [ 99 ], and eugenol [ 100 ]. Based on our experience in generating amyloid structures in insulin, we have also proposed a modification in the generation of rodent AD-like model : instead of injecting abeta amyloids to the animals brains, we used insulin amyloids which are easier formed at a lower cost [ 101 ].…”

Section: Proteins Aggregation: Formation Of Pathogenic Speciesmentioning

confidence: 99%

Modeling and simulation in medical sciences: an overview of specific applications based on research experience in EMRI (Endocrinology and Metabolism Research Institute of Tehran University of Medical Sciences)

Ebrahim‐Habibi

Kashani-Amin

Larijani

2021

J Diabetes Metab Disord

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The concomitant use of various types of models (in silico, in vitro, and in vivo) has been exemplified here within the context of biomedical researches performed in the Endocrinology and Metabolism Research Institute (EMRI) of Tehran University of Medical Sciences. Two main research aeras have been discussed: the search for new small molecules as therapeutics for diabetes and related metabolic conditions, and diseases related to protein aggregation. Due to their multidisciplinary nature, the majority of these studies have needed the collaboration of different specialties. In both cases, a brief overview of the subject is provided through literature examples, and sequential use of these methods is described.

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“…In gerbils, it has also been shown to protect against ischemiainduced brain toxicity (24). It also prevents amyloid protein aggregation (25) and thus prevents symptoms associated with Alzheimer's disease in insulin and Aβinduced rat models (26). Eugenol also aided functional recovery after traumatic brain injury by reducing oxidative stress and neuronal death (27) and is also effective against spinal cord injury in rats (28).…”

Section: Introductionmentioning

confidence: 99%

Effects of eugenol on the behavioral and pathological progression in the MPTP-induced Parkinson's disease mouse model

Vora

Vyas

Wal

et al. 2022

DD&T

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Parkinson's disease (PD) is the world's second most common neurological disorder. Oxidative stress and neuroinflammation play a crucial role in the pathogenesis of PD. Eugenol is a phytochemical with potent antioxidant and anti-inflammatory activity. The present investigation is aimed to study the effect of eugenol in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced mouse model of PD and its relationship to antioxidant effect. The effects of seven days of oral pre-treatment and post-treatment with three doses of eugenol (25, 50 and 100 mg/kg/day) were investigated against the MPTP-induced PD mouse model. In addition to the assessment of behavioural parameters using various tests (actophotometer, beam walking test, catalepsy, rearing, rotarod), biochemical parameters including lipid peroxidation and reduced glutathione levels in brain tissues, were also estimated in this study. The binding mode of eugenol in the human myeloid differentiation factor-2 (hMD-2) was also studied. Results showed that MPTP administration in mice resulted in the development of motor dysfunction (impaired motor coordination and hypo locomotion) similar to that of PD in different behavioural studies. Pre-treatment with eugenol reversed motor dysfunction caused by MPTP administration while post-treatment with eugenol at a high dose aggravated the symptoms of akinesia associated with MPTP administration. MPTP resulted in increased lipid peroxidation while decreased reduced glutathione levels in the brains of mice. MPTP-induced increased lipid peroxidation and attenuated levels of reduced glutathione were found to be alleviated with eugenol pre-treatment while augmented with eugenol post-treatment. Eugenol showed a binding affinity of -6.897 kcal/mol against the MD2 coreceptor of toll-like receptor-4 (TLR4). Biochemical, as well as neurobehavioral studies, showed that eugenol is having a protective effect, but does not have a curative effect on PD.

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Effects of Eugenol on Alzheimer’s Disease-like Manifestations in Insulin- and Aβ-Induced Rat Models

Cited by 20 publications

References 22 publications

Antioxidants in Alzheimer’s Disease: Current Therapeutic Significance and Future Prospects

Antioxidants in Alzheimer’s Disease: Current Therapeutic Significance and Future Prospects

Modeling and simulation in medical sciences: an overview of specific applications based on research experience in EMRI (Endocrinology and Metabolism Research Institute of Tehran University of Medical Sciences)

Effects of eugenol on the behavioral and pathological progression in the MPTP-induced Parkinson's disease mouse model

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