Effects of Eucalyptol in respiratory system mechanics on acute lung injury after exposure to short-term cigarette smoke

Gondim, Fladimir de Lima; Serra, Daniel Silveira; Cavalcante, Francisco Sales Ávila

doi:10.1016/j.resp.2019.04.007

Cited by 22 publications

(7 citation statements)

References 36 publications

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“…All procedures for respiratory system mechanics analysis were previously reported (Gondim et al 2019 ). In brief, the animals were anesthetized (ketamine:xylazine 100:10 mg/kg), tracheostomized, intubated (14-gauge cannula), and then connected to a computer-controlled ventilator for small animals (Scireq-flexiVent, Montreal, QC, Canada).…”

Section: Methodsmentioning

confidence: 99%

“…All procedures for histological analysis were previously reported (Gondim et al 2019 ). In brief, immediately after the determination of respiratory system mechanics, the lungs were perfused with saline and then removed en bloc , and was kept at functional residual capacity and fixed in Millonig’s formaldehyde (100 ml HCHO, 900 ml H 2 O, 18.6 g NaH 2 PO 4 , 4.2 g NaOH).…”

Section: Methodsmentioning

confidence: 99%

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Effects of Anacardic Acid Monoene on the Respiratory System of Mice Submitted to Acute Respiratory Distress Syndrome

Gondim

Ferreira

Nogueira

et al. 2021

Rev. Bras. Farmacogn.

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Graphical abstract The acute respiratory distress syndrome caused by viral pathogens is a worldwide public health emergency. It is suggested that patients with this condition should be screened using therapies that address the need to prevent mortality. Anacardic acids found in Anacardium species have biological activities related to the antioxidant capacity of their double bonds in the lateral alkyl chain. The present study seeks to investigate the effects of anacardic acid monoene on acute respiratory distress syndrome caused by lipopolysaccharides. Experiments were carried out on mice divided into three groups: control group, acute respiratory distress-induced group, and anacardic acid monoene pretreated group, subsequently, induced to acute respiratory distress by lipopolysaccharides. Results showed that anacardic acid moeno was able to prevent changes in lung function and preserve its mechanical properties from containing inflammatory cell infiltrate, collapse of alveoli, and decreased airway resistance, suggesting that this compound may be effective in preventing the acute respiratory distress syndrome caused by viral pathogens. Supplementary Information The online version contains supplementary material available at 10.1007/s43450-021-00151-8.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Effects of Anacardic Acid Monoene on the Respiratory System of Mice Submitted to Acute Respiratory Distress Syndrome

Gondim

Ferreira

Nogueira

et al. 2021

Rev. Bras. Farmacogn.

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“…Using a similar design, a further study with inhaled concentrations of eucalyptus oil (10-300 mg/kg) also reports prevention of lung injury [61]. A new review is focusing on the importance of controlling various disease mechanisms of oxidative stress in chronic respiratory diseases (CRDs) including asthma, COPD, respiratory infections, and also lung cancer, which are not sufficiently controlled by available anti-inflammatory therapies, such as ICS, LABAs, NF-jB inhibitors, mitogen-activated protein kinase p38 (MAPK p38) inhibitors and PDE-IV inhibitors with no effect on disease progression in COPD [62].…”

Section: á-mentioning

confidence: 97%

New Perspectives for Mucolytic, Anti-inflammatory and Adjunctive Therapy with 1,8-Cineole in COPD and Asthma: Review on the New Therapeutic Approach

2020

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The mucolytic monoterpene 1,8-cineole (eucalyptol), the major constituent of eucalyptus species, is well known for its anti-inflammatory, antioxidant, bronchodilatory, antiviral and antimicrobial effects. The main protective antiviral, anti-inflammatory and mucolytic mechanisms of 1,8-cineole are the induction of interferon regulatory factor 3 (IRF3), the control of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-jB) along with decreasing mucin genes (MUC2, MUC19). In normal human monocytes direct inhibition was shown of reactive oxygen species (ROS)-mediated mucus hypersecretion and of steroid resistence inducing superoxides (O 2 Á-) and pro-inflammatory hydrogen peroxides (H 2 O 2) with partial Digital Features To view digital features for this article go to

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“…It has low toxicity (LD 50 for rats 2.5 g/kg) [116]. It showed the ability to attenuate ALI in an animal model by different mechanisms [136,137]. A comprehensive review of the ability of essential oil to suppress several respiratory viruses was studied by Wani et al [138].…”

Section: Eucalyptol (18-cineole)mentioning

confidence: 99%

Phytochemicals against COVID -19, Pharmacological Perspectives: A Systematic Review

Ali

Saied

Theeban

et al. 2021

JPRI

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Background: Many publications discussed the potential role of medicinal plants in the management of COVID-19. However, clinical studies of the efficacy and safety of specified phytochemical(s) are limited. Objectives: To explore the pharmacological profile of specified compounds against COVID-19 Method: Systematic literature search of academic databases to explore specified phytochemicals for the management of COVID-19 using appropriate search terms. Rayyan software was used to organize 786 citations of which. 236 articles were included in this review. Results: Initially 70 compounds were identified to have a potential role in the management of COVID-19. In this review, 18 compounds were selected for further search Conclusion: In vitro anti-SARS-CoV-2activity has been demonstrated for a variety of natural compounds. However, preclinical research for most phytochemicals is scarce, and only a few compounds have been evaluated in clinical trials against COVID-19. A comprehensive pharmacological profile of these phytochemicals is urgently needed.

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Effects of Eucalyptol in respiratory system mechanics on acute lung injury after exposure to short-term cigarette smoke

Cited by 22 publications

References 36 publications

Effects of Anacardic Acid Monoene on the Respiratory System of Mice Submitted to Acute Respiratory Distress Syndrome

Effects of Anacardic Acid Monoene on the Respiratory System of Mice Submitted to Acute Respiratory Distress Syndrome

New Perspectives for Mucolytic, Anti-inflammatory and Adjunctive Therapy with 1,8-Cineole in COPD and Asthma: Review on the New Therapeutic Approach

Phytochemicals against COVID -19, Pharmacological Perspectives: A Systematic Review

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