Effects of ethanolic extract of Garcinia kola on sexual behaviour and sperm parameters in male Wistar rats

Ralebona, N.; Sewani-Rusike, Constance R; Nkeh-Chungag, Benedicta N.

doi:10.5897/ajpp11.652

Cited by 38 publications

(41 citation statements)

References 18 publications

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“…to exhibit effects such as hepato-protective (Iwu, 1985;Usifo et al, 2012;Adaramoye et al, 2005;Udenze et al, 2012;Galam et al, 2013), aphrodisiac (Ralebona et al, 2012;Bukar et al, 2016), antioxidant (Esomonu et al, 2005), hypoglycaemic (Iwu et al, 1990), antimicrobial (Adegboye et al, 2008;Gabriel et al, 2011;Jackie et al, 2014;Abah et al, 2014), analgesic, anti-inflammatory and antipyretic (Olaleye et al, 2000) properties among others. This study evaluated the immuno-stimulatory potential of the methanolic seed extract of G. kola in female albino rats.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of some metabolic activities and immuno-stimulatory potential of methanolic seed extract of Garcinia kola (Heckel) in female albino Wistar rats

Bukar¹,

Dayom²,

Okpeke³

et al. 2017

Afr. J. Pharm. Pharmacol.

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Evaluation of some metabolic activities and immuno-stimulatory potential of the methanolic seed extract of Garcinia kola (Heckel) in female albino Wistar rats was carried out using standard methods. Animals in treated groups were administered 125, 250 and 500 mg/kg body weight, respectively of the extract through the oral route for 21 days. The control group received normal saline (0.5 ml/100 g body weight) for the same period during which food and water intakes were monitored. At the end of the treatment period, complete and differential blood counts were evaluated for each group. Results show that the extract at the doses of 125 and 250 mg/kg caused significant increase in body weight of treated animals compared with those of control (p < 0.05). Similarly, there was significant increase in food and water intake as well as faecal and urine output in groups treated with 250 and 500 mg/kg (p < 0.05). Results of the complete blood count showed that the extract caused significant increase in total white blood cell count (WBC) (p < 0.05) but a non-significant increase in haemoglobin (p > 0.05). There was significant increase in lymphocytes in groups that received the extract at a dose of 125 mg/kg compared with control (p < 0.05). These results suggest that the methanolic seed extract of G. kola possesses immuno-stimulatory potential that may justify the ethno-medicinal claims of the efficacy of G. kola in treatment of some immune disorders.

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Section: Introductionmentioning

confidence: 99%

Evaluation of some metabolic activities and immuno-stimulatory potential of methanolic seed extract of Garcinia kola (Heckel) in female albino Wistar rats

Bukar¹,

Dayom²,

Okpeke³

et al. 2017

Afr. J. Pharm. Pharmacol.

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“…However, adequate intake of natural antioxidantrich foods such as fruits and vegetables could help combat oxidative stress and reduce the risk of developing several diseases such as diabetes, cardiovascular, neurodegenerative diseases and erectile/endothelial dysfunction (Ferreira et al 2006;Adefegha and Oboh 2012a,b;Landete, 2013). Hence, the search for medicinal plants and plant foods with sexualenhancing potential could serve as cheap and safe alternative therapy (Ralebona et al 2012). Hence, the search for medicinal plants and plant foods with sexualenhancing potential could serve as cheap and safe alternative therapy (Ralebona et al 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Management of ED with pharmaceutical drugs is associated with numerous side effects and toxicities. Hence, the search for medicinal plants and plant foods with sexualenhancing potential could serve as cheap and safe alternative therapy (Ralebona et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Erectogenic, Antihypertensive, Antidiabetic, Anti-Oxidative Properties and Phenolic Compositions of Almond Fruit (Terminalia catappaL.) Parts (Hull and Drupe) -in vitro

Adefegha

Oboh

Oyeleye

et al. 2016

Journal of Food Biochemistry

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This study was conducted to determine the effects of almond (Terminalia catappa L.) fruit parts (hull and drupe) extracts on key enzymes (arginase, angiotensin‐1‐converting enzyme, α‐amylase and α‐glucosidase) relevant to erectile dysfunction, type‐2 diabetes and hypertension, assess their antioxidant properties and characterize their phenolic constituents. The hull and drupe extracts were prepared by a mixture of absolute methanol and 1N HCl, evaporated to dryness and used for subsequent analysis. The result revealed that the hull and drupe extracts inhibited arginase, angiotensin‐1‐converting enzyme, α‐amylase and α‐glucosidase activities in a dose‐dependent manner. Both extracts scavenged radicals, reduced Fe3+ to Fe2+, chelated Fe2+ and inhibited lipid peroxidation in rat penile homogenate in vitro. Chlorogenic acid, ellagic acid and kaempferol were identified as the major phenolic compounds. This study suggests that these fruit parts can be natural sources of erectogenic, antihypertensive antidiabetic and anti‐oxidative agents. However, the hull showed better potential than the drupe. Practical Applications The results suggest that Almond (Terminalia catappa L.) fruit parts, including the hull and drupe, have potential applications as functional foods and nutraceuticals for both animal and human nutrition. In addition, the hull and drupe could be useful for therapeutic purposes as erectogenic, antihypertensive, antidiabetic and anti‐oxidative agents.

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“…Right cauda epididymis was separated and used for sperm count using the method of (Robb et al, 1978) and as we describe previously (Ralebona et al, 2012). Briefly, the isolated cauda epididymis was placed in a petri dish with 10 ml of warmed buffered normal saline, pH 7.2.…”

Section: Sperm Count and Motilitymentioning

confidence: 99%

“…Such food plants as garlic (Malviya et al, 2011), asparagus (Wani J.A. et al, 2011), Garcinia kola (Ralebona et al, 2012), Mondia whitei (Watcho et al, 2007a;Quasie et al, 2008) have been shown to improve erectile function and sexual performance in experimental animals. Mondia whitei (white's ginger), Sclerocarya birrea (marula) fruit, Chenopodium album (wild leafy vegetable), and Cucurbita pepo (pumpkin) seed are food products claimed to possess aphrodisiac activity (Table 1).…”

Section: Introductionmentioning

confidence: 99%

A comparative study on the aphrodisiac activity of food plants <i>Mondia whitei, Chenopodium album,Ccucurbita pepo</i> and <i>Sclerocarya birrea</i> extracts in male wistar rats

Sewani-Rusike¹,

Iputo²,

Ndebia³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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Background: Any substance that increases erectile function, sexual performance and enjoyment is considered an aphrodisiac. The aim of this study was to compare the effects of food plants Mondia whitei, Chenopodium album, Cucurbita pepo and Sclerocarya birrea extracts at a fixed dose of 200mg/kg body weight on sexual behavior, sperm parameters and testosterone levels in adult male rats. These are food plants also traditionally used as aphrodisiacs in South Africa, Zimbabwe and other parts of Africa. Materials and methods: Sexual behavior parameters assessed in this study included an arousal component (mount latency and intromission latency); sexual potency (mount frequency and intromission frequency), erection (copulatory efficiency) and ejaculations. All treatments were administered orally daily for 28 days. Sexual behavior parameters were quantified 2 hours after a single dose, at 14 days and at 28 days of treatment. Results: The order of efficacy in stimulating sexual behavior in male rats was M. whitei >S. birrea > C. pepo ≥ C. album. Although there was no change in number of ejaculations and sperm count (P>0.05) for all treatment groups compared to controls, all treatments increased (P<0.05) sperm motility. M. whitei and C. pepo treatments resulted in increased (P<0.05) serum testosterone levels. Conclusion: Therefore, this study demonstrates varying aphrodisiac activities of food plants used traditionally as aphrodisiacs.

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Effects of ethanolic extract of Garcinia kola on sexual behaviour and sperm parameters in male Wistar rats

Cited by 38 publications

References 18 publications

Evaluation of some metabolic activities and immuno-stimulatory potential of methanolic seed extract of Garcinia kola (Heckel) in female albino Wistar rats

Evaluation of some metabolic activities and immuno-stimulatory potential of methanolic seed extract of Garcinia kola (Heckel) in female albino Wistar rats

Erectogenic, Antihypertensive, Antidiabetic, Anti-Oxidative Properties and Phenolic Compositions of Almond Fruit (Terminalia catappaL.) Parts (Hull and Drupe) -in vitro

A comparative study on the aphrodisiac activity of food plants <i>Mondia whitei, Chenopodium album,Ccucurbita pepo</i> and <i>Sclerocarya birrea</i> extracts in male wistar rats

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