Effects of Ethanol on the Anticancer Function of Doxorubicin in JJ012 Cells

Huang, Hui; Li, Yanze; Wu, Mingjuan; Nie, Junhui; Hou, Baoyu; He, Qian; Diao, Ying; Lin, Qi; Zhao, Yuanyuan; Liu, Ying; Yang, Dan; Zhou, Lingyun

doi:10.2217/fon-2017-0547

Cited by 1 publication

(2 citation statements)

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“…However, the anti-tumor effects of ethanol adjuvant therapy on the STS field has not been established. Anti-tumor effects of ethanol on various types of cancers have been described, and the ethanol concentration [ 2 , 3 , 15 , 16 , 17 , 18 ] was likely to be a determining factor of these cancer treatments. Direct ethanol injection with high concentrations in hepatocellular and thyroid carcinoma led to a reduction of tumor relapse [ 2 , 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…Low concentrations of ethanol increase intracellular calcium concentrations and activate caspase 3/8, which induces apoptosis, thereby inducing an anti-tumor effect in vitro [ 15 , 16 ]. Several reports have shown that the addition of low concentrations of ethanol to anti-cancer drugs, such as doxorubicin and hyperthermia therapy, could enhance the effects of these treatments [ 16 , 17 ]. On the other hand, high concentrations of ethanol are known to have a dehydration effect, strong protein coagulation and denaturation, and necroptosis [ 18 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

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Anti-Tumor Effect and Neurotoxicity of Ethanol Adjuvant Therapy after Surgery of a Soft Tissue Sarcoma

Ban

Hoshi²,

Oebisu³

et al. 2023

Current Oncology

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Wide resection is the main treatment for sarcomas; however, when they are located near major nerves, their sacrifices might affect limb function. The efficacy of ethanol adjuvant therapy for sarcomas has not been established. In this study, the anti-tumor effect of ethanol, as well as its neurotoxicity, were assessed. In vitro anti-tumor effect of ethanol as evaluated using MTT, wound healing, and invasion assays on a synovial sarcoma cell line (HS-SY-II). In vivo, an assessment was conducted in nude mice (implanted with subcutaneous HS-SY-II) treated with different ethanol concentrations after surgery with a close margin. Sciatic nerve neurotoxicity was assessed with electrophysiological and histological examination. In vitro, ethanol concentrations at 30% and higher showed cytotoxic effects in MTT assay and markedly reduced migration and invasive ability of HS-SY-II. In vivo, both 30% and 99.5% ethanol concentrations, compared to 0% concentration, significantly reduced the local recurrence. However, in the group treated with 99.5% ethanol, nerve conduction tests showed prolonged latency and decreased amplitude, and morphological changes suggestive of nerve degeneration were observed in the sciatic nerve, while the 30% ethanol did not cause neurological damage. In conclusion, 30% is the optimal concentration for ethanol adjuvant therapy after close-margin surgery for sarcoma.

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