Effects of ethanol on psychomotor performance under steady-state conditions

Fagan, D.; Tiplady, B.; Scott, D.B.

doi:10.1177/026988119400800201

Cited by 8 publications

(3 citation statements)

References 16 publications

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“…This review identified seven studies that used a steady-state paradigm and five found evidence of acute behavioral tolerance. Two studies maintained a constant BAC by giving an initial oral dose to reach the desired BAC and then repeatedly giving oral maintenance doses throughout, but neither reported acute tolerance occurring on any measure (Fagan, Tiplady, & Scott, 1994; Kaplan, Sellers, Hamilton, Naranjo, & Dorian, 1985). The remaining five studies using the steady-state paradigm maintained a constant BAC through means of an intravenous clamp.…”

Section: Resultsmentioning

confidence: 99%

Acute behavioral tolerance to alcohol.

Comley

Dry

2020

Experimental and Clinical Psychopharmacology

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Although the strength of the effect produced by alcohol is generally dose dependent, its effect on behavior cannot be reliably predicted by the dose alone because the dose effect has been shown to vary. Acute behavioral tolerance is a rapid decrease in the dose effect of alcohol, seen to occur within the duration of a single dose. Numerous research paradigms have been used to examine acute behavioral tolerance, across an array of different behavioral measures. We have reviewed studies that used a research paradigm appropriate to test for acute behavioral tolerance. The primary aim was to examine the different paradigms that have been used to identify what empirical evidence of the effect has been found. The additional aims were to identify domains of behavior in which acute tolerance has been shown to occur and ascertain which conditions have been shown to influence it. Findings of acute tolerance were prevalent. Seven different research paradigms were identified, and each found evidence of acute behavioral tolerance in at least 1 study. The effect was not uniform across all behavioral measures. Subjective measures reliably showed the effect, but objective measures of behavior were less reliable, providing evidence that particular aspects of task performance are more sensitive to acute tolerance than others. The dose effect of alcohol for behavioral measures is often shown to decrease within the duration of a single dose. Investigations into, and considerations of, the effects of alcohol on behavior need to consider temporal changes in the dose effect.

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Section: Resultsmentioning

confidence: 99%

Acute behavioral tolerance to alcohol.

Comley

Dry

2020

Experimental and Clinical Psychopharmacology

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“…Others have attempted to demonstrate the development of acute tolerance to alcohol while BrAC was held constant (Fagan et al, 1994;Hiltunen et al, 2000;Kaplan et al, 1985). Approximate steady-state BrACs (albeit with high variance) were achieved in social drinkers with either intravenous or repeated oral administration of alcohol.…”

Section: Discussionmentioning

confidence: 99%

Self‐Reported Subjective Perception of Intoxication Reflects Family History of Alcoholism When Breath Alcohol Levels Are Constant

Morzorati

Ramchandani

Flury

et al. 2002

Alcoholism Clin & Exp Res

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“…Maze tests seem to be much less commonly used than they were before the advent of personal computers, although they are sensitive measures of drug effects (Frewer and Lader, 1993;Fagan et al, 1994). This may be related to the inconvenience of using paper-based tasks compared to tasks that can readily be automated.…”

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confidence: 99%

Validity and sensitivity of a pen computer battery of performance tests

Cameron¹,

Sinclair

Tiplady

2001

J Psychopharmacol

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This study compared administration of performance tests and visual analogue scales (VAS) using a newly developed pen computer (PenC) battery with established tests using either pencil-and-paper (PP) or conventional computer. The performance of 47 subjects (23 male, age 18-45 years, weight 51-112 kg) was compared on the two systems after a dose of ethanol (0.8 g/kg up to a maximum of 60 g for males, 50 g for females) or placebo in a double-blind two-period randomized crossover study. Mean (SD) blood ethanol concentrations (breathalyser) were 94.5 mg/100 ml (21.9) at the start of the test battery (30 min post-drink) and 80.2 (13.0) at the end of the battery (75 min post-drink). Ethanol effects were found in all tests, with most outcome measures showing significant slowing or loss of accuracy. Results from the Rapid Visual Information Processing, Sentence Verification and Continuous Attention tasks show that the ethanol-placebo difference and the statistical significance of this difference are in close correspondence for the two modes of administration. The pen computer versions of these tasks may therefore be used as direct replacements for the previous versions. Digit-Symbol and maze tasks did not correspond so closely both showing differences in the speed-accuracy trade-off between the two modes. These tests, however, are sensitive to the effects of ethanol, and may be useful in their own right. Principal component analysis suggested that VAS may be grouped into two factors: (1) 'functional integrity', including measures of alertness and perceived proficiency, and (2) 'mood', including happiness and sociability. Factor 1 showed substantial effects of ethanol, while factor 2 was unchanged. There was close agreement between the results from PP and PenC for both factors as well as for the Sober-Drunk scale, which showed the expected effects of ethanol. Thus pen computer VAS perform in a similar way to the PP versions.

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Effects of ethanol on psychomotor performance under steady-state conditions

Cited by 8 publications

References 16 publications

Acute behavioral tolerance to alcohol.

Acute behavioral tolerance to alcohol.

Self‐Reported Subjective Perception of Intoxication Reflects Family History of Alcoholism When Breath Alcohol Levels Are Constant

Validity and sensitivity of a pen computer battery of performance tests

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