Effects of ethanol on limited resuscitation in a model of traumatic brain injury and hemorrhagic shock

Zink, Brian J.; Stern, Susan A.; McBeth, Brian D.; Wang, Xu; Mertz, M.

doi:10.3171/jns.2006.105.6.884

Cited by 14 publications

(17 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The head is shaved and prepared with povidone iodine solution [73]. Afterwards, a 1 cm craniotomy is performed over the left front parietal area approximately 1 cm lateral to the midline and 1 cm rostral to the bregma [74, 75].…”

Section: Animal Models Simulating Traumatic Brain Injurymentioning

confidence: 99%

See 1 more Smart Citation

Experimental Trauma Models: An Update

Frink

Andruszkow

Zeckey

et al. 2011

BioMed Research International

View full text Add to dashboard Cite

Treatment of polytrauma patients remains a medical as well as socioeconomic challenge. Although diagnostics and therapy improved during the last decades, multiple injuries are still the major cause of fatalities in patients below 45 years of age. Organ dysfunction and organ failure are major complications in patients with major injuries and contribute to mortality during the clinical course. Profound understanding of the systemic pathophysiological response is crucial for innovative therapeutic approaches. Therefore, experimental studies in various animal models are necessary. This review is aimed at providing detailed information of common trauma models in small as well as in large animals.

show abstract

Section: Animal Models Simulating Traumatic Brain Injurymentioning

confidence: 99%

“…A hollow bolt is installed flush with the intact dura [74, 75]. Another craniotomy on the contralateral side allows introducing catheters for measurement of ICP and intracerebral temperature [73–75]. Therefore, the catheter is placed in the subdural space.…”

Section: Animal Models Simulating Traumatic Brain Injurymentioning

confidence: 99%

Experimental Trauma Models: An Update

Frink

Andruszkow

Zeckey

et al. 2011

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…16 Single vascular damage-induced uncontrolled hemorrhagic shock resulted in the same hemodynamic changes, coagulation disorders, and inflammation reaction as a model using organ damage and vascular injury. [17][18][19] However, this model cannot completely mimic the clinical scenario because the tissue damage in this model is not severe. The model of uncontrolled hemorrhagic shock adopted in the current study was induced by transection of splenic parenchyma and the splenic artery.…”

mentioning

confidence: 99%

Ideal Permissive Hypotension to Resuscitate Uncontrolled Hemorrhagic Shock and the Tolerance Time in Rats

Zhu²,

et al. 2011

Anesthesiology

View full text Add to dashboard Cite

Background: Studies have shown that permissive hypotension for uncontrolled hemorrhagic shock can result in good resuscitation outcome. The ideal target mean arterial pressure (MAP) and the tolerance time for permissive hypotension have not been determined. Methods: To elucidate the ideal target MAP and tolerance time for permissive hypotension with uncontrolled hemorrhagic shock rats, the effects of different target MAPs (40, 50, 60, 70, 80, and 100 mmHg) and 60-, 90-, and 120-min permissive hypotension (50 mmHg) on uncontrolled hemorrhagic shock were observed. Results: Rats in normotensive groups (80 and 100 mmHg) had increased blood loss (101%, 126% of total blood volume), decreased hematocrit, decreased vital organ (liver and kidney) and mitochondrial function, and decreased animal survival rate (1 of 10). Rats in the 50-and 60-mmHg target MAP groups had decreased blood loss (52% and 69%, respectively), good hematocrit and vital organ and mitochondrial function, stable hemodynamics, and increased animal survival (8 of 10 and 6 of 10, respectively). Rats in the 40-mmHg target MAP group, although having decreased blood loss (39%), appeared to have very inferior organ function and animal survival (2 of 10). Animal survival (1 of 10) and vital

show abstract

“…Organ damage in combination with vascular injury can imitate uncontrolled hemorrhagic shock, but this model is not easy to reproduce because of severe tissue impairment [22]. Single vascular damage induced-uncontrolled hemorrhagic shock had the same hemodynamic change, the same coagulation disorder, and the same inflammation reaction as organ damage plus the vascular injury model [23][24][25], but this model cannot completely mimic the clinical scenario because the tissue damage in this model is not severe. The model of uncontrolled hemorrhagic shock adopted in the present study was induced by splenic parenchyma and one of splenic artery transaction.…”

Section: Discussionmentioning

confidence: 97%

A Small Dose of Arginine Vasopressin in Combination with Norepinephrine is a Good Early Treatment for Uncontrolled Hemorrhagic Shock After Hemostasis

Li¹,

Fang²,

Zhu

et al. 2011

Journal of Surgical Research

View full text Add to dashboard Cite

Effects of ethanol on limited resuscitation in a model of traumatic brain injury and hemorrhagic shock

Abstract: Ethanol intoxication led to increased hemorrhage volume and worsened hemodynamic and metabolic profiles in this model of limited resuscitation after TBI and HS. Ethanol-exposed animals had increased resuscitation requirements and decreased survival times.

Cited by 14 publications

References 60 publications

Experimental Trauma Models: An Update

Experimental Trauma Models: An Update

Ideal Permissive Hypotension to Resuscitate Uncontrolled Hemorrhagic Shock and the Tolerance Time in Rats

A Small Dose of Arginine Vasopressin in Combination with Norepinephrine is a Good Early Treatment for Uncontrolled Hemorrhagic Shock After Hemostasis

Contact Info

Product

Resources

About